Protein Overview: tankyrase-PA

General Information:
Name(s) found:	tankyrase-PA / FBpp0084264 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|7301359\|gb\|AAF56487.1\| tankyrase [Drosophila melanogaster] [NCBI NR] gi\|21356741\|ref\|NP_651410.1\| tankyrase [Drosophila melanogaster] [NCBI NR] gi\|201065653\|gb\|ACH92236.1\| FI03751p [Drosophila melanogaster] [NCBI NR] Tankyrase OS=Drosophila melanogaster GN=Tnks PE=1 SV=1 [Swiss-Prot] The gene tankyrase is referred to in FlyBase by the symbol Dmel\tankyrase (CG4719, FBgn0027508). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:21478807..21487003. It has the cytological map location 96E7-96E8. Based on sequence similarity, it is predicted to have molecular function</span>: structural constituent of cytoskeleton. Based on sequence similarity, it is predicted to be involved in the biological process</span>: cytoskeletal anchoring at plasma membrane. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase] >CG4719-PA translation from_gene[CG4719 BcDNA:LD22548 FBgn0027508] seq_release:3 mol_weight=127946 cds_boundaries:(3R:21,469,622..21,475,874[-]) aa_length:1181 transcript_info:[CG4719-RA seq_release:3] gene_info:[gene symbol:BcDNA:LD22548 synonyms:[CG1 [hmr_yeast5_DM3-1_pombe.fasta] (Q9VBP3) BCDNA:LD22548 protein [DrosMelano7227.FASTAC.txt] (AE003752) BcDNA:LD22548 gene product [Drosophila melanogaster] [yeastflysequest.fasta] CG4719-PA [Drosophila melanogaster]gi\|21356741\|ref\|NP_651410.1\| CG4719-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas] type=protein; loc=3R:complement(21480254..21480331,21480392..21480548,21480617..21480909,21480974..21481131,21481192..21483072,21483137..21483919,21486314..21486509); ID=FBpp0084264; name=tankyrase-PA; parent=FBgn0027508,FBtr0084890; dbxref=FlyBase:FBpp00 [fly-100309-contam.fasta] tankyrase CG4719-PA [Drosophila melanogaster] [nr-271106-contam.fasta] CG4719-PA [Drosophila melanogaster] [nr-271106-contam.fasta] type=protein; loc=3R:complement(21480254..21480331,21480392..21480548,21480617..21480909,21480974..21481131,21481192..21483072,21483137..21483919,21486314..21486509); ID=FBpp0084264; name=tankyrase-PA; parent=FBgn0027508,FBtr0084890; dbxref=FlyBase:FBpp0084264,FlyBase_Annotation_IDs:CG4719-PA,GB_protein:AAF56487.1,REFSEQ:NP_651410,GB_protein:AAF56487; MD5=08f82e0c29e4511c75440c22eda3fd1a; length=1181; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=3R:complement(21480254..21480331,21480392..21480548,21480617..21480909,21480974..21481131,21481192..21483072,21483137..21483919,21486314..21486509); ID=FBpp0084264; name=tankyrase-PA; parent=FBgn0027508,FBtr0084890; dbxref=FlyBase:FBpp0084264,FlyBase_Annotation_IDs:CG4719-PA,GB_protein:AAF56487.1,REFSEQ:NP_651410,GB_protein:AAF56487; MD5=08f82e0c29e4511c75440c22eda3fd1a; length=1181; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] FI03751p OS=Drosophila melanogaster GN=tankyrase PE=2 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta] type=protein; loc=3R:complement(21480254..21480331,21480392..21480548,21480617..21480909,21480974..21481131,21481192..21483072,21483137..21483919,21486314..21486509); ID=FBpp0084264; name=tankyrase-PA; parent=FBgn0027508,FBtr0084890; dbxref=FlyBase:FBpp0084264,FlyBase_Annotation_IDs:CG4719-PA,GB_protein:AAF56487.1,REFSEQ:NP_651410,GB_protein:AAF56487,FlyMine:FBpp0084264,modMine:FBpp0084264; MD5=08f82e0c29e4511c75440c22eda3fd1a; length=1181; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] type=protein; loc=3R:complement(join(25660592..25660787,25657415..25658197,25655470..25657350,25655252..25655409,25654895..25655187,25654670..25654826,25654532..25654609)); ID=FBpp0084264; name=Tnks-PA; parent=FBgn0027508,FBtr0084890; dbxref=FlyBase:FBpp0084264,FlyBase_Annotation_IDs:CG4719-PA,GB_protein:AAF56487.1,REFSEQ:NP_651410,GB_protein:AAF56487,FlyMine:FBpp0084264,modMine:FBpp0084264; MD5=08f82e0c29e4511c75440c22eda3fd1a; length=1181; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=3R:complement(join(25660592..25660787,25657415..25658197,25655470..25657350,25655252..25655409,25654895..25655187,25654670..25654826,25654532..25654609)); ID=FBpp0084264; name=Tnks-PA; parent=FBgn0027508,FBtr0084890; dbxref=FlyBase:FBpp0084264,FlyBase_Annotation_IDs:CG4719-PA,GB_protein:AAF56487.1,REFSEQ:NP_651410,GB_protein:AAF56487,FlyMine:FBpp0084264,modMine:FBpp0084264; MD5=08f82e0c29e4511c75440c22eda3fd1a; length=1181; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] FBpp0084264 type=protein; loc=3R:complement(join(25660592..25660787,25657415..25658197,25655470..25657350,25655252..25655409,25654895..25655187,25654670..25654826,25654532..25654609)); ID=FBpp0084264; name=Tnks-PA; parent=FBgn0027508,FBtr0084890; dbxref=FlyBase:FBpp0084264,FlyBase_Annotation_IDs:CG4719-PA,GB_protein:AAF56487.1,REFSEQ:NP_651410,GB_protein:AAF56487,FlyMine:FBpp0084264,modMine:FBpp0084264; MD5=08f82e0c29e4511c75440c22eda3fd1a; length=1181; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] [fly-122215-dmel-6-09-contam.fasta] type=protein; loc=3R:complement(join(25660592..25660787,25657415..25658197,25655470..25657350,25655252..25655409,25654895..25655187,25654670..25654826,25654532..25654609)); ID=FBpp0084264; name=Tnks-PA; parent=FBgn0027508,FBtr0084890; dbxref=FlyBase:FBpp0084264,FlyBase_Annotation_IDs:CG4719-PA,GB_protein:AAF56487.1,REFSEQ:NP_651410,GB_protein:AAF56487,UniProt/Swiss-Prot:Q9VBP3,FlyMine:FBpp0084264,modMine:FBpp0084264; MD5=08f82e0c29e4511c75440c22eda3fd1a; length=1181; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
Organism:	Drosophila melanogaster
Length:	1181 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	cytoskeletal anchoring at plasma membrane [ISS]
Molecular Function:	structural constituent of cytoskeleton [ISS] NAD+ ADP-ribosyltransferase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MANSSRSRAI LSVNLDAVMA NDPLRELFEA CKTGEIAKVK KLITPQTVNA RDTAGRKSTP  60
   61 LHFAAGYGRR EVVEFLLNSG ASIQACDEGG LHPLHNCCSF GHAEVVRLLL KAGASPNTTD 120
  121 NWNYTPLHEA ASKGKVDVCL ALLQHGANHT IRNSEQKTPL ELADEATRPV LTGEYRKDEL 180
  181 LEAARSGAED RLLALLTPLN VNCHASDGRR STPLHLAAGY NRIGIVEILL ANGADVHAKD 240
  241 KGGLVPLHNA CSYGHFDVTK LLIQAGANVN ANDLWAFTPL HEAASKSRVE VCSLLLSRGA 300
  301 DPTLLNCHSK SAIDAAPTRE LRERIAFEYK GHCLLDACRK CDVSRAKKLV CAEIVNFVHP 360
  361 YTGDTPLHLA VVSPDGKRKQ LMELLTRKGS LLNEKNKAFL TPLHLAAELL HYDAMEVLLK 420
  421 QGAKVNALDS LGQTPLHRCA RDEQAVRLLL SYAADTNIVS LEGLTAAQLA SDSVLKLLKN 480
  481 PPDSETHLLE AAKAGDLDTV RRIVLNNPIS VNCRDLDGRH STPLHFAAGF NRVPVVQFLL 540
  541 EHGAEVYAAD KGGLVPLHNA CSYGHYEVTE LLVKHGANVN VSDLWKFTPL HEAAAKGKYD 600
  601 ICKLLLKHGA DPMKKNRDGA TPADLVKESD HDVAELLRGP SALLDAAKKG NLARVQRLVT 660
  661 PESINCRDAQ GRNSTPLHLA AGYNNFECAE YLLENGADVN AQDKGGLIPL HNASSYGHLD 720
  721 IAALLIKHKT VVNATDKWGF TPLHEAAQKG RTQLCSLLLA HGADAYMKNQ EGQTPIELAT 780
  781 ADDVKCLLQD AMATSLSQQA LSASTQSLTS SSPAPDATAA AAPGTSSSSS SAILSPTTET 840
  841 VLLPTGASMI LSVPVPLPLS SSTRISPAQG AEANGAEGSS SDDLLPDADT ITNVSGFLSS 900
  901 QQLHHLIELF EREQITLDIL AEMGHDDLKQ VGVSAYGFRH KILKGIAQLR STTGIGNNVN 960
  961 LCTLLVDLLP DDKEFVAVEE EMQATIREHR DNGQAGGYFT RYNIIRVQKV QNRKLWERYA1020
 1021 HRRQEIAEEN FLQSNERMLF HGSPFINAIV QRGFDERHAY IGGMFGAGIY FAEHSSKSNQ1080
 1081 YVYGIGGGIG CPSHKDKSCY VCPRQLLLCR VALGKSFLQY SAMKMAHAPP GHHSVVGRPS1140
 1141 AGGLHFAEYV VYRGEQSYPE YLITYQIVKP DDSSSGTEDT R

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

[What does the above image mean?]
[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..253]	PSI-BLAST	45.69897	X-ray structure of human gankyrin
2	View Details	[254..319]	PSI-BLAST	45.0	Crystal structure of a designed selected Ankyrin Repeat protein in complex with the Maltose Binding Protein
3	View Details	[320..395]	PSI-BLAST	13.30103	Pyk2-associated protein beta; Pyk2-associated protein beta ARF-GAP domain
4	View Details	[396..802]	PSI-BLAST	97.09691	Ankyrin-R
5	View Details	[803..858]	PSI-BLAST	44.0	No description for 2dvwA was found.
6	View Details	[859..951]	FFAS03	3.6	No description for 2e8oA was found.
7	View Details	[952..1181]	PSI-BLAST	35.154902	No description for 2rf5A was found.

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
cytoskeletal protein binding	3.30812396303844	bayes_pls_golite062009
cyclin-dependent protein kinase regulator activity	2.74680100300795	bayes_pls_golite062009
binding	2.60916417202222	bayes_pls_golite062009
structural constituent of cytoskeleton	2.4948065111495	bayes_pls_golite062009
hydrolase activity	2.43232200709693	bayes_pls_golite062009
protein binding	1.64872738860757	bayes_pls_golite062009
actin binding	1.57116090936036	bayes_pls_golite062009
cyclin-dependent protein kinase inhibitor activity	1.55735067984073	bayes_pls_golite062009
transcription regulator activity	1.4354270769219	bayes_pls_golite062009
ubiquitin-protein ligase activity	1.23556500721571	bayes_pls_golite062009
small conjugating protein ligase activity	1.13900029077952	bayes_pls_golite062009
molecular transducer activity	1.05530241844863	bayes_pls_golite062009
signal transducer activity	1.05530241844863	bayes_pls_golite062009
DNA binding	1.02969244915531	bayes_pls_golite062009
transcription repressor activity	0.996021523724457	bayes_pls_golite062009
kinase activity	0.973206891506661	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.954469238725827	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.876784788207113	bayes_pls_golite062009
nucleic acid binding	0.875210074973845	bayes_pls_golite062009
structural molecule activity	0.808967137205604	bayes_pls_golite062009
transporter activity	0.782432203646924	bayes_pls_golite062009
protein kinase binding	0.78130842943004	bayes_pls_golite062009
kinase binding	0.75961315755729	bayes_pls_golite062009
ion channel activity	0.73200897518931	bayes_pls_golite062009
transcription factor binding	0.71111931011795	bayes_pls_golite062009
protein kinase activity	0.663511836722598	bayes_pls_golite062009
transmembrane transporter activity	0.653190853243002	bayes_pls_golite062009
transcription factor activity	0.614673057254056	bayes_pls_golite062009
enzyme binding	0.60140077251711	bayes_pls_golite062009
substrate-specific transporter activity	0.515634991066501	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.375391185084903	bayes_pls_golite062009
actin filament binding	0.356911481111024	bayes_pls_golite062009
receptor activity	0.302775974564672	bayes_pls_golite062009
transferase activity	0.298084176742023	bayes_pls_golite062009
gated channel activity	0.26482178002103	bayes_pls_golite062009
acid-amino acid ligase activity	0.247967126091535	bayes_pls_golite062009
ion transmembrane transporter activity	0.238966076323951	bayes_pls_golite062009
cation channel activity	0.17724823105167	bayes_pls_golite062009
transmembrane receptor activity	0.0831408532151166	bayes_pls_golite062009
passive transmembrane transporter activity	0.0675641359654993	bayes_pls_golite062009
channel activity	0.0675641359654993	bayes_pls_golite062009
protein serine/threonine kinase inhibitor activity	0.0500658306142403	bayes_pls_golite062009

No functions predicted.

Term	Confidence	Notes
cytoskeletal protein binding	3.30812396303844	bayes_pls_golite062009
cyclin-dependent protein kinase regulator activity	2.74680100300795	bayes_pls_golite062009
binding	2.60916417202222	bayes_pls_golite062009
structural constituent of cytoskeleton	2.4948065111495	bayes_pls_golite062009
hydrolase activity	2.43232200709693	bayes_pls_golite062009
protein binding	1.64872738860757	bayes_pls_golite062009
actin binding	1.57116090936036	bayes_pls_golite062009
cyclin-dependent protein kinase inhibitor activity	1.55735067984073	bayes_pls_golite062009
transcription regulator activity	1.4354270769219	bayes_pls_golite062009
ubiquitin-protein ligase activity	1.23556500721571	bayes_pls_golite062009
small conjugating protein ligase activity	1.13900029077952	bayes_pls_golite062009
molecular transducer activity	1.05530241844863	bayes_pls_golite062009
signal transducer activity	1.05530241844863	bayes_pls_golite062009
DNA binding	1.02969244915531	bayes_pls_golite062009
transcription repressor activity	0.996021523724457	bayes_pls_golite062009
kinase activity	0.973206891506661	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.954469238725827	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.876784788207113	bayes_pls_golite062009
nucleic acid binding	0.875210074973845	bayes_pls_golite062009
structural molecule activity	0.808967137205604	bayes_pls_golite062009
transporter activity	0.782432203646924	bayes_pls_golite062009
protein kinase binding	0.78130842943004	bayes_pls_golite062009
kinase binding	0.75961315755729	bayes_pls_golite062009
ion channel activity	0.73200897518931	bayes_pls_golite062009
transcription factor binding	0.71111931011795	bayes_pls_golite062009
protein kinase activity	0.663511836722598	bayes_pls_golite062009
transmembrane transporter activity	0.653190853243002	bayes_pls_golite062009
transcription factor activity	0.614673057254056	bayes_pls_golite062009
enzyme binding	0.60140077251711	bayes_pls_golite062009
substrate-specific transporter activity	0.515634991066501	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.375391185084903	bayes_pls_golite062009
actin filament binding	0.356911481111024	bayes_pls_golite062009
receptor activity	0.302775974564672	bayes_pls_golite062009
transferase activity	0.298084176742023	bayes_pls_golite062009
gated channel activity	0.26482178002103	bayes_pls_golite062009
acid-amino acid ligase activity	0.247967126091535	bayes_pls_golite062009
ion transmembrane transporter activity	0.238966076323951	bayes_pls_golite062009
cation channel activity	0.17724823105167	bayes_pls_golite062009
transmembrane receptor activity	0.0831408532151166	bayes_pls_golite062009
passive transmembrane transporter activity	0.0675641359654993	bayes_pls_golite062009
channel activity	0.0675641359654993	bayes_pls_golite062009
protein serine/threonine kinase inhibitor activity	0.0500658306142403	bayes_pls_golite062009

No functions predicted.

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.53

Protein Overview: tankyrase-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: