YRC Public Data Repository - Protein Structure Prediction

Protein:	tankyrase-PA
Organism:	Drosophila melanogaster
Length:	1181 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for tankyrase-PA.

Description	E-value	Query Range	Subject Range
gi\|115686265, gi... - gi\|115971326\|ref\|XP_001188862.1\| PREDICTED: similar to ankyrin 2,3/unc44 [Strongylocentrotus purpura...	1219.0	[0..2]	[1180..247]

Back

Predicted Domain #1

Region A:
Residues: [1-253]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MANSSRSRAI LSVNLDAVMA NDPLRELFEA CKTGEIAKVK KLITPQTVNA RDTAGRKSTP  60
   61 LHFAAGYGRR EVVEFLLNSG ASIQACDEGG LHPLHNCCSF GHAEVVRLLL KAGASPNTTD 120
  121 NWNYTPLHEA ASKGKVDVCL ALLQHGANHT IRNSEQKTPL ELADEATRPV LTGEYRKDEL 180
  181 LEAARSGAED RLLALLTPLN VNCHASDGRR STPLHLAAGY NRIGIVEILL ANGADVHAKD 240
  241 KGGLVPLHNA CSY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	45.69897
Match:	1qymA
Description:	X-ray structure of human gankyrin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
cytoskeletal protein binding	3.30812396303844	bayes_pls_golite062009
cyclin-dependent protein kinase regulator activity	2.74680100300795	bayes_pls_golite062009
binding	2.60916417202222	bayes_pls_golite062009
structural constituent of cytoskeleton	2.4948065111495	bayes_pls_golite062009
hydrolase activity	2.43232200709693	bayes_pls_golite062009
protein binding	1.64872738860757	bayes_pls_golite062009
actin binding	1.57116090936036	bayes_pls_golite062009
cyclin-dependent protein kinase inhibitor activity	1.55735067984073	bayes_pls_golite062009
transcription regulator activity	1.4354270769219	bayes_pls_golite062009
ubiquitin-protein ligase activity	1.23556500721571	bayes_pls_golite062009
small conjugating protein ligase activity	1.13900029077952	bayes_pls_golite062009
molecular transducer activity	1.05530241844863	bayes_pls_golite062009
signal transducer activity	1.05530241844863	bayes_pls_golite062009
DNA binding	1.02969244915531	bayes_pls_golite062009
transcription repressor activity	0.996021523724457	bayes_pls_golite062009
kinase activity	0.973206891506661	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.954469238725827	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.876784788207113	bayes_pls_golite062009
nucleic acid binding	0.875210074973845	bayes_pls_golite062009
structural molecule activity	0.808967137205604	bayes_pls_golite062009
transporter activity	0.782432203646924	bayes_pls_golite062009
protein kinase binding	0.78130842943004	bayes_pls_golite062009
kinase binding	0.75961315755729	bayes_pls_golite062009
ion channel activity	0.73200897518931	bayes_pls_golite062009
transcription factor binding	0.71111931011795	bayes_pls_golite062009
protein kinase activity	0.663511836722598	bayes_pls_golite062009
transmembrane transporter activity	0.653190853243002	bayes_pls_golite062009
transcription factor activity	0.614673057254056	bayes_pls_golite062009
enzyme binding	0.60140077251711	bayes_pls_golite062009
substrate-specific transporter activity	0.515634991066501	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.375391185084903	bayes_pls_golite062009
actin filament binding	0.356911481111024	bayes_pls_golite062009
receptor activity	0.302775974564672	bayes_pls_golite062009
transferase activity	0.298084176742023	bayes_pls_golite062009
gated channel activity	0.26482178002103	bayes_pls_golite062009
acid-amino acid ligase activity	0.247967126091535	bayes_pls_golite062009
ion transmembrane transporter activity	0.238966076323951	bayes_pls_golite062009
cation channel activity	0.17724823105167	bayes_pls_golite062009
transmembrane receptor activity	0.0831408532151166	bayes_pls_golite062009
passive transmembrane transporter activity	0.0675641359654993	bayes_pls_golite062009
channel activity	0.0675641359654993	bayes_pls_golite062009
protein serine/threonine kinase inhibitor activity	0.0500658306142403	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [254-319]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GHFDVTKLLI QAGANVNAND LWAFTPLHEA ASKSRVEVCS LLLSRGADPT LLNCHSKSAI  60
   61 DAAPTR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	45.0
Match:	1svxA
Description:	Crystal structure of a designed selected Ankyrin Repeat protein in complex with the Maltose Binding Protein
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [320-395]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ELRERIAFEY KGHCLLDACR KCDVSRAKKL VCAEIVNFVH PYTGDTPLHL AVVSPDGKRK  60
   61 QLMELLTRKG SLLNEK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	13.30103
Match:	1dcqA
Description:	Pyk2-associated protein beta; Pyk2-associated protein beta ARF-GAP domain
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [396-802]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKAFLTPLHL AAELLHYDAM EVLLKQGAKV NALDSLGQTP LHRCARDEQA VRLLLSYAAD  60
   61 TNIVSLEGLT AAQLASDSVL KLLKNPPDSE THLLEAAKAG DLDTVRRIVL NNPISVNCRD 120
  121 LDGRHSTPLH FAAGFNRVPV VQFLLEHGAE VYAADKGGLV PLHNACSYGH YEVTELLVKH 180
  181 GANVNVSDLW KFTPLHEAAA KGKYDICKLL LKHGADPMKK NRDGATPADL VKESDHDVAE 240
  241 LLRGPSALLD AAKKGNLARV QRLVTPESIN CRDAQGRNST PLHLAAGYNN FECAEYLLEN 300
  301 GADVNAQDKG GLIPLHNASS YGHLDIAALL IKHKTVVNAT DKWGFTPLHE AAQKGRTQLC 360
  361 SLLLAHGADA YMKNQEGQTP IELATADDVK CLLQDAMATS LSQQALS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	97.09691
Match:	1n11A
Description:	Ankyrin-R
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
cytoskeletal protein binding	3.30812396303844	bayes_pls_golite062009
cyclin-dependent protein kinase regulator activity	2.74680100300795	bayes_pls_golite062009
binding	2.60916417202222	bayes_pls_golite062009
structural constituent of cytoskeleton	2.4948065111495	bayes_pls_golite062009
hydrolase activity	2.43232200709693	bayes_pls_golite062009
protein binding	1.64872738860757	bayes_pls_golite062009
actin binding	1.57116090936036	bayes_pls_golite062009
cyclin-dependent protein kinase inhibitor activity	1.55735067984073	bayes_pls_golite062009
transcription regulator activity	1.4354270769219	bayes_pls_golite062009
ubiquitin-protein ligase activity	1.23556500721571	bayes_pls_golite062009
small conjugating protein ligase activity	1.13900029077952	bayes_pls_golite062009
molecular transducer activity	1.05530241844863	bayes_pls_golite062009
signal transducer activity	1.05530241844863	bayes_pls_golite062009
DNA binding	1.02969244915531	bayes_pls_golite062009
transcription repressor activity	0.996021523724457	bayes_pls_golite062009
kinase activity	0.973206891506661	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.954469238725827	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.876784788207113	bayes_pls_golite062009
nucleic acid binding	0.875210074973845	bayes_pls_golite062009
structural molecule activity	0.808967137205604	bayes_pls_golite062009
transporter activity	0.782432203646924	bayes_pls_golite062009
protein kinase binding	0.78130842943004	bayes_pls_golite062009
kinase binding	0.75961315755729	bayes_pls_golite062009
ion channel activity	0.73200897518931	bayes_pls_golite062009
transcription factor binding	0.71111931011795	bayes_pls_golite062009
protein kinase activity	0.663511836722598	bayes_pls_golite062009
transmembrane transporter activity	0.653190853243002	bayes_pls_golite062009
transcription factor activity	0.614673057254056	bayes_pls_golite062009
enzyme binding	0.60140077251711	bayes_pls_golite062009
substrate-specific transporter activity	0.515634991066501	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.375391185084903	bayes_pls_golite062009
actin filament binding	0.356911481111024	bayes_pls_golite062009
receptor activity	0.302775974564672	bayes_pls_golite062009
transferase activity	0.298084176742023	bayes_pls_golite062009
gated channel activity	0.26482178002103	bayes_pls_golite062009
acid-amino acid ligase activity	0.247967126091535	bayes_pls_golite062009
ion transmembrane transporter activity	0.238966076323951	bayes_pls_golite062009
cation channel activity	0.17724823105167	bayes_pls_golite062009
transmembrane receptor activity	0.0831408532151166	bayes_pls_golite062009
passive transmembrane transporter activity	0.0675641359654993	bayes_pls_golite062009
channel activity	0.0675641359654993	bayes_pls_golite062009
protein serine/threonine kinase inhibitor activity	0.0500658306142403	bayes_pls_golite062009

Predicted Domain #5

Region A:
Residues: [803-858]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ASTQSLTSSS PAPDATAAAA PGTSSSSSSA ILSPTTETVL LPTGASMILS VPVPLP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	44.0
Match:	2dvwA
Description:	No description for 2dvwA was found.

Predicted Domain #6

Region A:
Residues: [859-951]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSSSTRISPA QGAEANGAEG SSSDDLLPDA DTITNVSGFL SSQQLHHLIE LFEREQITLD  60
   61 ILAEMGHDDL KQVGVSAYGF RHKILKGIAQ LRS

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	3.6
Match:	2e8oA
Description:	No description for 2e8oA was found.

Predicted Domain #7

Region A:
Residues: [952-1181]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TTGIGNNVNL CTLLVDLLPD DKEFVAVEEE MQATIREHRD NGQAGGYFTR YNIIRVQKVQ  60
   61 NRKLWERYAH RRQEIAEENF LQSNERMLFH GSPFINAIVQ RGFDERHAYI GGMFGAGIYF 120
  121 AEHSSKSNQY VYGIGGGIGC PSHKDKSCYV CPRQLLLCRV ALGKSFLQYS AMKMAHAPPG 180
  181 HHSVVGRPSA GGLHFAEYVV YRGEQSYPEY LITYQIVKPD DSSSGTEDTR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	35.154902
Match:	2rf5A
Description:	No description for 2rf5A was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: