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Protein Overview: tankyrase-PA

General Information:
Name(s) found: tankyrase-PA / FBpp0084264 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene tankyrase is referred to in FlyBase by the symbol Dmel\tankyrase (CG4719, FBgn0027508). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:21478807..21487003. It has the cytological map location 96E7-96E8. Based on sequence similarity, it is predicted to have molecular function</span>: structural constituent of cytoskeleton. Based on sequence similarity, it is predicted to be involved in the biological process</span>: cytoskeletal anchoring at plasma membrane. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1181 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: cytoskeletal anchoring at plasma membrane [ISS]
    Molecular Function: structural constituent of cytoskeleton [ISS]
    NAD+ ADP-ribosyltransferase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MANSSRSRAI LSVNLDAVMA NDPLRELFEA CKTGEIAKVK KLITPQTVNA RDTAGRKSTP  60
   61 LHFAAGYGRR EVVEFLLNSG ASIQACDEGG LHPLHNCCSF GHAEVVRLLL KAGASPNTTD 120
  121 NWNYTPLHEA ASKGKVDVCL ALLQHGANHT IRNSEQKTPL ELADEATRPV LTGEYRKDEL 180
  181 LEAARSGAED RLLALLTPLN VNCHASDGRR STPLHLAAGY NRIGIVEILL ANGADVHAKD 240
  241 KGGLVPLHNA CSYGHFDVTK LLIQAGANVN ANDLWAFTPL HEAASKSRVE VCSLLLSRGA 300
  301 DPTLLNCHSK SAIDAAPTRE LRERIAFEYK GHCLLDACRK CDVSRAKKLV CAEIVNFVHP 360
  361 YTGDTPLHLA VVSPDGKRKQ LMELLTRKGS LLNEKNKAFL TPLHLAAELL HYDAMEVLLK 420
  421 QGAKVNALDS LGQTPLHRCA RDEQAVRLLL SYAADTNIVS LEGLTAAQLA SDSVLKLLKN 480
  481 PPDSETHLLE AAKAGDLDTV RRIVLNNPIS VNCRDLDGRH STPLHFAAGF NRVPVVQFLL 540
  541 EHGAEVYAAD KGGLVPLHNA CSYGHYEVTE LLVKHGANVN VSDLWKFTPL HEAAAKGKYD 600
  601 ICKLLLKHGA DPMKKNRDGA TPADLVKESD HDVAELLRGP SALLDAAKKG NLARVQRLVT 660
  661 PESINCRDAQ GRNSTPLHLA AGYNNFECAE YLLENGADVN AQDKGGLIPL HNASSYGHLD 720
  721 IAALLIKHKT VVNATDKWGF TPLHEAAQKG RTQLCSLLLA HGADAYMKNQ EGQTPIELAT 780
  781 ADDVKCLLQD AMATSLSQQA LSASTQSLTS SSPAPDATAA AAPGTSSSSS SAILSPTTET 840
  841 VLLPTGASMI LSVPVPLPLS SSTRISPAQG AEANGAEGSS SDDLLPDADT ITNVSGFLSS 900
  901 QQLHHLIELF EREQITLDIL AEMGHDDLKQ VGVSAYGFRH KILKGIAQLR STTGIGNNVN 960
  961 LCTLLVDLLP DDKEFVAVEE EMQATIREHR DNGQAGGYFT RYNIIRVQKV QNRKLWERYA1020
 1021 HRRQEIAEEN FLQSNERMLF HGSPFINAIV QRGFDERHAY IGGMFGAGIY FAEHSSKSNQ1080
 1081 YVYGIGGGIG CPSHKDKSCY VCPRQLLLCR VALGKSFLQY SAMKMAHAPP GHHSVVGRPS1140
 1141 AGGLHFAEYV VYRGEQSYPE YLITYQIVKP DDSSSGTEDT R

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..253] PSI-BLAST 45.69897 X-ray structure of human gankyrin
    2 View Details [254..319] PSI-BLAST 45.0 Crystal structure of a designed selected Ankyrin Repeat protein in complex with the Maltose Binding Protein
    3 View Details [320..395] PSI-BLAST 13.30103 Pyk2-associated protein beta; Pyk2-associated protein beta ARF-GAP domain
    4 View Details [396..802] PSI-BLAST 97.09691 Ankyrin-R
    5 View Details [803..858] PSI-BLAST 44.0 No description for 2dvwA was found.
    6 View Details [859..951] FFAS03 3.6 No description for 2e8oA was found.
    7 View Details [952..1181] PSI-BLAST 35.154902 No description for 2rf5A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • cytoskeletal protein binding
    		•  3.30812396303844 bayes_pls_golite062009
  • cyclin-dependent protein kinase regulator activity
    		•  2.74680100300795 bayes_pls_golite062009
  • binding
    		•  2.60916417202222 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  2.4948065111495 bayes_pls_golite062009
  • hydrolase activity
    		•  2.43232200709693 bayes_pls_golite062009
  • protein binding
    		•  1.64872738860757 bayes_pls_golite062009
  • actin binding
    		•  1.57116090936036 bayes_pls_golite062009
  • cyclin-dependent protein kinase inhibitor activity
    		•  1.55735067984073 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.4354270769219 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  1.23556500721571 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  1.13900029077952 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.05530241844863 bayes_pls_golite062009
  • signal transducer activity
    		•  1.05530241844863 bayes_pls_golite062009
  • DNA binding
    		•  1.02969244915531 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.996021523724457 bayes_pls_golite062009
  • kinase activity
    		•  0.973206891506661 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.954469238725827 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.876784788207113 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.875210074973845 bayes_pls_golite062009
  • structural molecule activity
    		•  0.808967137205604 bayes_pls_golite062009
  • transporter activity
    		•  0.782432203646924 bayes_pls_golite062009
  • protein kinase binding
    		•  0.78130842943004 bayes_pls_golite062009
  • kinase binding
    		•  0.75961315755729 bayes_pls_golite062009
  • ion channel activity
    		•  0.73200897518931 bayes_pls_golite062009
  • transcription factor binding
    		•  0.71111931011795 bayes_pls_golite062009
  • protein kinase activity
    		•  0.663511836722598 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.653190853243002 bayes_pls_golite062009
  • transcription factor activity
    		•  0.614673057254056 bayes_pls_golite062009
  • enzyme binding
    		•  0.60140077251711 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.515634991066501 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.375391185084903 bayes_pls_golite062009
  • actin filament binding
    		•  0.356911481111024 bayes_pls_golite062009
  • receptor activity
    		•  0.302775974564672 bayes_pls_golite062009
  • transferase activity
    		•  0.298084176742023 bayes_pls_golite062009
  • gated channel activity
    		•  0.26482178002103 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  0.247967126091535 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.238966076323951 bayes_pls_golite062009
  • cation channel activity
    		•  0.17724823105167 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.0831408532151166 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.0675641359654993 bayes_pls_golite062009
  • channel activity
    		•  0.0675641359654993 bayes_pls_golite062009
  • protein serine/threonine kinase inhibitor activity
    		•  0.0500658306142403 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • cytoskeletal protein binding
    		•  3.30812396303844 bayes_pls_golite062009
  • cyclin-dependent protein kinase regulator activity
    		•  2.74680100300795 bayes_pls_golite062009
  • binding
    		•  2.60916417202222 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  2.4948065111495 bayes_pls_golite062009
  • hydrolase activity
    		•  2.43232200709693 bayes_pls_golite062009
  • protein binding
    		•  1.64872738860757 bayes_pls_golite062009
  • actin binding
    		•  1.57116090936036 bayes_pls_golite062009
  • cyclin-dependent protein kinase inhibitor activity
    		•  1.55735067984073 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.4354270769219 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  1.23556500721571 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  1.13900029077952 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.05530241844863 bayes_pls_golite062009
  • signal transducer activity
    		•  1.05530241844863 bayes_pls_golite062009
  • DNA binding
    		•  1.02969244915531 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.996021523724457 bayes_pls_golite062009
  • kinase activity
    		•  0.973206891506661 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.954469238725827 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.876784788207113 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.875210074973845 bayes_pls_golite062009
  • structural molecule activity
    		•  0.808967137205604 bayes_pls_golite062009
  • transporter activity
    		•  0.782432203646924 bayes_pls_golite062009
  • protein kinase binding
    		•  0.78130842943004 bayes_pls_golite062009
  • kinase binding
    		•  0.75961315755729 bayes_pls_golite062009
  • ion channel activity
    		•  0.73200897518931 bayes_pls_golite062009
  • transcription factor binding
    		•  0.71111931011795 bayes_pls_golite062009
  • protein kinase activity
    		•  0.663511836722598 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.653190853243002 bayes_pls_golite062009
  • transcription factor activity
    		•  0.614673057254056 bayes_pls_golite062009
  • enzyme binding
    		•  0.60140077251711 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.515634991066501 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.375391185084903 bayes_pls_golite062009
  • actin filament binding
    		•  0.356911481111024 bayes_pls_golite062009
  • receptor activity
    		•  0.302775974564672 bayes_pls_golite062009
  • transferase activity
    		•  0.298084176742023 bayes_pls_golite062009
  • gated channel activity
    		•  0.26482178002103 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  0.247967126091535 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.238966076323951 bayes_pls_golite062009
  • cation channel activity
    		•  0.17724823105167 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.0831408532151166 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.0675641359654993 bayes_pls_golite062009
  • channel activity
    		•  0.0675641359654993 bayes_pls_golite062009
  • protein serine/threonine kinase inhibitor activity
    		•  0.0500658306142403 bayes_pls_golite062009
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.53

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle