Protein Overview: Fur1-PA

General Information:
Name(s) found:	Fur1-PA / FBpp0089025 [FlyBase]
Description(s) found: Found 25 descriptions. SHOW ALL	The gene Furin 1 is referred to in FlyBase by the symbol Dmel\Fur1 (CG10772, FBgn0004509). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:21173090..21298778. It has the cytological map location 96D2-96E1. There is experimental evidence that it has the molecular function</span>: serine-type endopeptidase activity. It is reported to be involved in the biological process</span>: proteolysis. 27 alleles are reported. No phenotypic data is available. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	1101 amino acids
Gene Ontology:
Cellular Component:	integral to Golgi membrane [NAS] integral to membrane [NAS] Golgi stack [NAS] plasma membrane [IDA][ISS]
Biological Process:	proteolysis [IEA][NAS]
Molecular Function:	serine-type endopeptidase activity [IDA][NAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKNDVVRWSR QPTSNTTNSS SSSRSDSNST HKHRSKSNKL NARQLGSNAA RSCQQRSSVA  60
   61 TTLEDEQQTI IECDIGNFNF DCNLFKTSFL TQHKQKRSGK SSSKSKSNRS RPLAKTKAVF 120
  121 LLALQFSAVV FLCNINVGFV AGSVATAASS AGGSSPAAPS SAPSSPPTVA VPPPPPPSSA 180
  181 LKVDPNGQSP VLPPYVLDYE TGGKAKLTPN NGKFGQSGSS GSNNNHIVGH YTHTWAVHIP 240
  241 NGDNGMADAV AKDHGFVNLG KIFDDHYHFA HHKVSKRSLS PATHHQTRLD DDDRVHWAKQ 300
  301 QRAKSRSKRD FIRMRPSRTS SRAMSMVDAM SFNDSKWPQM WYLNRGGGLD MNVIPAWKMG 360
  361 ITGKGVVVTI LDDGLESDHP DIQDNYDPKA SYDVNSHDDD PMPHYDMTDS NRHGTRCAGE 420
  421 VAATANNSFC AVGIAYGASV GGVRMLDGDV TDAVEARSLS LNPQHIDIYS ASWGPDDDGK 480
  481 TVDGPGELAS RAFIEGTTKG RGGKGSIFIW ASGNGGREQD NCNCDGYTNS IWTLSISSAT 540
  541 EEGHVPWYSE KCSSTLATTY SSGGQGEKQV VTTDLHHSCT VSHTGTSASA PLAAGIAALV 600
  601 LQSNQNLTWR DLQHIVVRTA KPANLKDPSW SRNGVGRRVS HSFGYGLMDA AEMVRVARNW 660
  661 KAVPEQQRCE INAPHVDKVI PPRTHITLQL TVNHCRSVNY LEHVQAKITL TSQRRGDIQL 720
  721 FLRSPANTSV TLLTPRIHDN SRSGFNQWPF MSVHTWGESP QGNWQLEIHN EGRYMAQITQ 780
  781 WDMIFYGTET PAQPDDVANP SQSNQFNLYG NDMAHNDVEY DSTGQWRNMQ QVGEVGMTRD 840
  841 HSNTAACLKW SDRKCLECND SAYMFEDQCY DVCPVHTYPL DKFQAEEDEQ DDEVTRGPVN 900
  901 PYSSSPMDHS LLMSNSLDDK QDPLQAEDRR RRSSLTQLVE VPSRVCAACD RSCLECYGAL 960
  961 ASQCSTCSPG SQLRKILNET FCYAYVVRST GMASVVDISK MDDRDTQQYM TGTTVLLLVS1020
 1021 VIFTLMGVAV AGGIVYHRRA MARSNELYSR VSLVPGDESD SDEDELFTAH FPARKSGVNI1080
 1081 YRDEAPSEKI FEEDEISHLV P

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..169]	deduced	N/A	No confident structure predictions are available.
2	View Details	[170..332]	PSI-BLAST	13.522879	High Resolution Crystal Structure of the Intact Pro-Kumamolisin, a Sedolisin Type Proteinase (previously called Kumamolysin or KSCP)
3	View Details	[333..787]	PSI-BLAST	93.69897	Furin, C-terminal domain; Furin, N-terminal domain
4	View Details	[788..1101]	PSI-BLAST	11.30103	Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor

Functions predicted (by domain):

#

Gene Ontology predictions

1

No functions predicted.

2

No functions predicted.

3

Term	Confidence	Notes
nerve growth factor binding	5.17216805931457	bayes_pls_golite062009
peptidase activity	4.77677490610016	bayes_pls_golite062009
neurotrophin binding	4.47215080222714	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	4.40501322467328	bayes_pls_golite062009
serine hydrolase activity	4.30899317351154	bayes_pls_golite062009
serine-type peptidase activity	4.29545891350519	bayes_pls_golite062009
endopeptidase activity	3.83336601331518	bayes_pls_golite062009
serine-type endopeptidase activity	3.71508033196614	bayes_pls_golite062009
hydrolase activity	2.1123944590511	bayes_pls_golite062009
eukaryotic cell surface binding	1.50287724152407	bayes_pls_golite062009
binding	1.08901362883653	bayes_pls_golite062009
catalytic activity	0.597535457699629	bayes_pls_golite062009
exopeptidase activity	0.42083764849682	bayes_pls_golite062009
protein binding	0.380935140681308	bayes_pls_golite062009
receptor binding	0.222369968782666	bayes_pls_golite062009
glycosaminoglycan binding	0.22219445619715	bayes_pls_golite062009

4

Term	Confidence	Notes
receptor binding	3.29563208013266	bayes_pls_golite062009
growth factor activity	2.98754787930869	bayes_pls_golite062009
ErbB-2 class receptor binding	2.47588813698806	bayes_pls_golite062009
binding	2.35148208532935	bayes_pls_golite062009
ErbB-3 class receptor binding	1.91029895687059	bayes_pls_golite062009
protein binding	1.87564165872234	bayes_pls_golite062009
glycosaminoglycan binding	1.69932456942774	bayes_pls_golite062009
heparin binding	1.31822233987881	bayes_pls_golite062009
transcription regulator activity	1.02533871020185	bayes_pls_golite062009
pattern binding	0.889457267222739	bayes_pls_golite062009
extracellular matrix structural constituent	0.87690248187077	bayes_pls_golite062009
transcription factor binding	0.84948501276694	bayes_pls_golite062009
polysaccharide binding	0.815272766842889	bayes_pls_golite062009
epidermal growth factor receptor binding	0.78842039074146	bayes_pls_golite062009
transcription cofactor activity	0.77044611170692	bayes_pls_golite062009
signal transducer activity	0.600269003770368	bayes_pls_golite062009
molecular transducer activity	0.600269003770368	bayes_pls_golite062009
carbohydrate binding	0.0269430386148981	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

Philius confidence legend

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