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Protein Overview: nct-PA, nct-PC

General Information:
Name(s) found: nct-PC / FBpp0291079 [FlyBase]
nct-PA / FBpp0084083 [FlyBase]
Description(s) found:
Found 28 descriptions.
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  • The gene nicastrin is referred to in FlyBase by the symbol Dmel\nct (CG7012, FBgn0039234). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:20677294..20680730. It has the cytological map location 96B1. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process</span>: Notch receptor processing; membrane protein ectodomain proteolysis; Notch signaling pathway; cytoskeleton organization. 28 alleles are reported. The phenotypes of these alleles are annotated with: larva; eye; dorsal mesothoracic disc. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
  • The gene nicastrin is referred to in FlyBase by the symbol Dmel\nct (CG7012, FBgn0039234). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:20677294..20680730. It has the cytological map location 96B1. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process</span>: Notch receptor processing; membrane protein ectodomain proteolysis; Notch signaling pathway; cytoskeleton organization. 28 alleles are reported. The phenotypes of these alleles are annotated with: larva; eye; dorsal mesothoracic disc. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 695 amino acids

    Gene Ontology:
    Cellular Component: integral to membrane [IEA][NAS]
    plasma membrane [NAS]
    Biological Process: Notch signaling pathway [IMP][NAS]
    membrane protein ectodomain proteolysis [IMP][NAS]
    cytoskeleton organization [IMP]
    Notch receptor processing [IGI][IMP]
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEMRLNAASI WLLILSYGAT IAQGERTRDK MYEPIGGASC FRRLNGTHQT GCSSTYSGSV  60
   61 GVLHLINVEA DLEFLLSSPP SPPYAPMIPP HLFTRNNLMR LKEAGPKNIS VVLLINRTNQ 120
  121 MKQFSHELNC PNQYSGLNST SETCDASNPA KNWNPWGTGL LHEDFPFPIY YIADLDQVTK 180
  181 LEKCFQDFNN HNYETHALRS LCAVEVKSFM SAAVNTEVCM RRTNFINNLG GSKYCDPLEG 240
  241 RNVYATLYPR KPAIENNLET VHTNEKFILV TCRLDTTTMF DGVGLGAMDS LMGFAVFTHV 300
  301 AYLLKQLLPP QSKDLHNVLF VTFNGESYDY IGSQRFVYDM EKLQFPTEST GTPPIAFDNI 360
  361 DFMLDIGTLD DISNIKLHAL NGTTLAQQIL ERLNNYAKSP RYGFNLNIQS EMSAHLPPTS 420
  421 AQSFLRRDPN FNALILNARP TNKYYHSIYD DADNVDFTYA NTSKDFTQLT EVNDFKSLNP 480
  481 DSLQMKVRNV SSIVAMALYQ TITGKEYTGT KVANPLMADE FLYCFLQSAD CPLFKAASYP 540
  541 GSQLTNLPPM RYISVLGGSQ ESSGYTYRLL GYLLSQLQPD IHRDNCTDLP LHYFAGFNNI 600
  601 GECRLTTQNY SHALSPAFLI DGYDWSSGMY STWTESTWSQ FSARIFLRPS NVHQVTTLSV 660
  661 GIVVLIISFC LVYIISSRSE VLFEDLPASN AALFG

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..530] PSI-BLAST 79.39794 No description for 2ootA was found.
    2 View Details [531..695] MSA 1.167976 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • peptidase activity
    		•  4.69852272549237 bayes_pls_golite062009
  • hydrolase activity
    		•  4.23257784904124 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  4.21193944512431 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  3.68442839136734 bayes_pls_golite062009
  • receptor activity
    		•  3.43249110530054 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.61784313760368 bayes_pls_golite062009
  • signal transducer activity
    		•  2.61784313760368 bayes_pls_golite062009
  • metallopeptidase activity
    		•  2.04062448553328 bayes_pls_golite062009
  • exopeptidase activity
    		•  1.5759162922092 bayes_pls_golite062009
  • catalytic activity
    		•  1.3989281287879 bayes_pls_golite062009
  • binding
    		•  0.899461642061592 bayes_pls_golite062009
  • carboxypeptidase activity
    		•  0.891655769761122 bayes_pls_golite062009
  • endopeptidase activity
    		•  0.529831416345723 bayes_pls_golite062009
  • metalloexopeptidase activity
    		•  0.472688733072762 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.385009026435495 bayes_pls_golite062009
  • metallocarboxypeptidase activity
    		•  0.180859448845431 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.140274984043468 bayes_pls_golite062009
  • aminopeptidase activity
    		•  0.0966237570696103 bayes_pls_golite062009
  • protein binding
    		•  0.00854198798870509 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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