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Protein Overview: twin-PD

General Information:
Name(s) found: twin-PD / FBpp0083955 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene twin is referred to in FlyBase by the symbol Dmel\twin (CG31137, FBgn0011725). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:20023310..20047687. It has the cytological map location 95F1-95F2. Based on sequence similarity, it is predicted to have molecular function</span>: transcription regulator activity. There is experimental evidence that it is involved in the biological process</span>: oogenesis; nuclear-transcribed mRNA poly(A) tail shortening. 23 alleles are reported. The phenotypes of these alleles are annotated with: nurse cell ring canal; oocyte; egg chamber; nurse cell. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 358 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDA][ISS]
    CCR4-NOT complex [ISS]
    Biological Process: oogenesis [IMP]
    nuclear-transcribed mRNA poly(A) tail shortening [IMP]
    nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [ISS]
    regulation of transcription from RNA polymerase II promoter [ISS]
    Molecular Function: protein binding [IEA]
    transcription regulator activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCYNVLCDKY ATRQMYGYCP SWALCWEYRK KSIIDEIRHY AADIISLQEI ETEQFYHFFL  60
   61 PELKNDGYEG IFSPKSRAKT MSELERKYVD GCAIFFRASK FTLIKESLIE FNQLAMANAE 120
  121 GSDNMLNRVM PKDNIGLAAL LKVKENAWEP MSEVTQISQP LLVCTAHIHW DPEFCDVKLI 180
  181 QTMMLSNELK TIIDEASHSF RPGHKNDSNA VQLLLCGDFN SLPDSGVVEF LGKGRVSMDH 240
  241 LDFKDMGYKS CLQRLLSNDT NEFTHSFKLA SAYNEDIMPH TNYTFDFKGI IDYIFYTKTG 300
  301 MVPLGLLGPV SNDWLRENKV VGCPHPHIPS DHFPLLVELE LMHTASQQAP PNGLINRR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..358] PSI-BLAST 22.0 No description for 2ddrA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • hydrolase activity
    		•  3.28400034252781 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  3.04161110413795 bayes_pls_golite062009
  • DNA binding
    		•  2.38216646754749 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.37867140645121 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.37728600449241 bayes_pls_golite062009
  • nuclease activity
    		•  1.78432551160775 bayes_pls_golite062009
  • catalytic activity
    		•  1.76511376991978 bayes_pls_golite062009
  • binding
    		•  1.74593496417303 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  1.6713040226181 bayes_pls_golite062009
  • transcription coactivator activity
    		•  1.51022821676155 bayes_pls_golite062009
  • exonuclease activity
    		•  1.44893971411928 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  1.25010124971419 bayes_pls_golite062009
  • oxidoreductase activity
    		•  1.00650797438916 bayes_pls_golite062009
  • ribonuclease activity
    		•  0.934548175624486 bayes_pls_golite062009
  • transcription activator activity
    		•  0.885026804340494 bayes_pls_golite062009
  • transcription factor binding
    		•  0.77254170640454 bayes_pls_golite062009
  • exodeoxyribonuclease activity, producing 5'-phosphomonoesters
    		•  0.738975226345995 bayes_pls_golite062009
  • exodeoxyribonuclease activity
    		•  0.73001958440393 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.58884884939295 bayes_pls_golite062009
  • protein binding
    		•  0.476649214025345 bayes_pls_golite062009
  • endonuclease activity
    		•  0.288539805949629 bayes_pls_golite062009
  • inositol or phosphatidylinositol phosphatase activity
    		•  0.228910502815798 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  0.100365481550461 bayes_pls_golite062009
  • phosphatase activity
    		•  0.00559251346312178 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle