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Protein Overview: DNApol-epsilon-PA

General Information:
Name(s) found: DNApol-epsilon-PA / FBpp0083800 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene DNA polymerase Ã?&#142;Ã?µ is referred to in FlyBase by the symbol Dmel\DNApol-Ã?&#142;Ã?µ (CG6768, FBgn0020756). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:19173913..19180890. It has the cytological map location 94E13. There is experimental evidence that it has the molecular function</span>: DNA-directed DNA polymerase activity; 3'-5'-exodeoxyribonuclease activity. There is experimental evidence that it is involved in the biological process</span>: DNA-dependent DNA replication; cellular response to DNA damage stimulus. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 2236 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    epsilon DNA polymerase complex [ISS]
    Biological Process: DNA replication [IEA]
    DNA-dependent DNA replication [IDA]
    response to DNA damage stimulus [IMP]
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process [IEA]
    Molecular Function: nucleotide binding [IEA]
    DNA binding [IEA]
    DNA-directed DNA polymerase activity [IDA][ISS][NAS]
    zinc ion binding [IEA]
    3'-5'-exodeoxyribonuclease activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDSSKGKVL QNTGKFVSEN RTEGDDFFNE AGYRQSREND KIDSKYGFDR VKDSQERTGY  60
   61 LINMHSNEVL DEDRRLIAAL DLFFIQMDGS RFKCTVAYQP YLLIRPEDNM HLEVARFLGR 120
  121 KYSGQISGLE HITKEDLDLP NHLSGLQQQY IKLSFLNQTA MTKVRRELMS AVKRNQERQK 180
  181 SNTYYMQMLA TSLAQSSAGS EDATLGKRQQ DYMDCIVDIR EHDVPYHVRV SIDLRIFCGQ 240
  241 WYNIRCRSGV ELPTITCRPD ILDRPEPVVL AFDIETTKLP LKFPDAQTDQ VMMISYMIDG 300
  301 QGYLITNREI ISSNVDDFEY TPKPEFEGNF IVFNEENEMQ LLQRFFDHIM EVRPHIIVTY 360
  361 NGDFFDWPFV ETRAAVYDLD MKQEIGFSKL RDGNYLSRPA IHMDCLCWVK RDSYLPVGSQ 420
  421 GLKAVAKAKL RYDPVELDPE DMCRMAVEQP QVLANYSVSD AVATYYLYMK YVHPFIFALN 480
  481 TIIPMEPDEI LRKGSGTLCE TLLMVEAYHA QIVYPNKHQS ELNKLSNEGH VLDSETYVGG 540
  541 HVEALESGVF RADIPCRFRL DPAMVKQLQE QVDAVLRHAI EVEEGIPLEK VLNLDEVRQE 600
  601 IVQGLQGLHD IPNRLEQPVI YHLDVGAMYP NIILTNRLQP SAMVSDLDCA ACDFNKPGVR 660
  661 CKRSMDWLWR GEMLPASRNE FQRIQQQLET EKFPPLFPGG PQRAFHELSK EDQAAYEKKR 720
  721 LTDYCRKAYK KTKLTKLETR TSTICQKENS FYVDTVRAFR DRRYEYKGLT KVAKASVNAA 780
  781 VASGDAAEIK AAKGREVLYD SLQLAHKCIL NSFYGYVMRR GARWHSMPMA GIVCLTGSNI 840
  841 ITKAREIIER VGRPLELDTD GIWCILPGSF PQEFTIHTSH EKKKKINISY PNAVLNTMVK 900
  901 DHFTNDQYHE LRKDKENNLP KYDIRDENSI FFEVDGPYLA MVLPAAKEEG KKLKKRYAVF 960
  961 NFDGTLAELK GFEVKRRGEL QLIKNFQSSV FEAFLAGSTL EECYASVAKV ADYWLDVLYS1020
 1021 RGSNLPDSEL FELISENKSM SKKLEEYGAQ KSTSISTAKR LAEFLGEQMV KDAGLACKYI1080
 1081 ISKKPEGAPV TERAIPLAIF QSEPSVRRHH LRRWLKDNTM GDADIRDVLD WNYYIERLGG1140
 1141 TIQKIITIPA ALQGLANPVP RVQHPDWLHK KMLEKNDVLK QRRINEMFTS RPKPKPLATE1200
 1201 EDKLADMEDL AGKDGGEGAA GCPIVTKRKR IQLEEHDDEE AQPQATTWRQ ALGAPPPIGE1260
 1261 TRKTIVEWVR FQKKKWKWQQ DQRQRNRQAS KRTRGEDPPV VRATGSTATL GGFLRRAQRT1320
 1321 LLDQPWQIVQ LVPVDDLGHF TVWALIGEEL HKIKLTVPRI FYVNQRSAAP PEEGQLWRKV1380
 1381 NRVLPRSRPV FNLYRYSVPE QLFRDNSLGM LADLATPDIE GIYETQMTLE FRALMDMGCI1440
 1441 CGVQREEARR LAQLATKDLE TFSIEQLEQR PQTQVKYLAS ANNRLRKIYL YQHNTPTAKK1500
 1501 EIWSLILMPS KKAFVFALDT VRANQMPNMR QLYTAERLAL LKNLTAEEQD KIPVEDYTFE1560
 1561 VLIEVDVKQI YRHIQRALTT YKQEHQGPTI LCLQTALSAR KLSLAMPILL EFPQAEIHIS1620
 1621 DDASLLSGLD WQRQGSRAVI RHFLNLNNVL DLMLDQCRYF HVPIGNMPPD TVLFGADLFF1680
 1681 ARLLQRHNFV LWWSASTRPD LGGREADDSR LLAEFEESIS VVQNKAGFYP DVCVELALDS1740
 1741 LAVSALLQST RIQEMEGASS AITFDVMPQV SLEEMIGTVP AATLPSYDET ALCSAAFRVM1800
 1801 RSMVNGWLRE VSINRNIFSD FQIVHFYRWV RSSNALLYDP ALRRSLNNLM RKMFLRIIAE1860
 1861 FKRLGATIIY ADFNRIILSS GKKTVSDALG YVDYIVQSLR NKEMFHSIQL SFEQCWNFML1920
 1921 WMDQANFSGI RGKLPKGIDE TVSSIVSTTM IRDSERNQDD DEDEEEDSEN RDPVESNEAE1980
 1981 QDQEDELSLE LNWTIGEHLP DENECREKFE SLLTLFMQSL AEKKTTEQAI KDISHCAFDF2040
 2041 ILKLHKNYGK GKPSPGLELI RTLIKALSVD KTLAEQINEL RRNMLRLVGI GEFSDLAEWE2100
 2101 DPCDSHIINE VICKACNHCR DLDLCKDKHR AMKDGVPVWL CAQCYVAYDN EEIEMRMLDA2160
 2161 LQRKMMSYVL QDLRCSRCSE IKRENLAEFC TCAGNFVPLI SGKDIQTLLG TFNKVAANHK2220
 2221 MQLLQQTVHQ ALTTPR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..819] PSI-BLAST 98.69897 Exonuclease domain of family B (archaeal and phage) DNA polymerases; T4-like DNA polymerase
    2 View Details [820..1139] FFAS03 4.18 Crystal structure of ESCHERICHIA coli DNA Polymerase II
    3 View Details [1140..1240] deduced N/A No confident structure predictions are available.
    4 View Details [1241..1417] deduced N/A No confident structure predictions are available.
    5 View Details [1418..1495] deduced N/A No confident structure predictions are available.
    6 View Details [1496..1596] MSA 1.040979 View MSA. No confident structure predictions are available.
    7 View Details [1597..1754] deduced N/A No confident structure predictions are available.
    8 View Details [1755..1924] deduced N/A No confident structure predictions are available.
    9 View Details [1925..2136] deduced N/A No confident structure predictions are available.
    10 View Details [2137..2236] MSA 9.050987 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA-directed DNA polymerase activity
    		•  11.2781960093187 bayes_pls_golite062009
  • DNA polymerase activity
    		•  11.2285838712952 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  8.85826259809475 bayes_pls_golite062009
  • DNA primase activity
    		•  7.3506495327575 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.79232184185512 bayes_pls_golite062009
  • endonuclease activity
    		•  4.4589129578563 bayes_pls_golite062009
  • endodeoxyribonuclease activity
    		•  4.26114862034453 bayes_pls_golite062009
  • transferase activity
    		•  4.02382113115178 bayes_pls_golite062009
  • DNA binding
    		•  2.71295423886311 bayes_pls_golite062009
  • RNA polymerase activity
    		•  2.69726786045171 bayes_pls_golite062009
  • DNA-directed RNA polymerase activity
    		•  2.69726786045171 bayes_pls_golite062009
  • ribonuclease activity
    		•  2.66669472409706 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.64264099197997 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  2.58611070700103 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.20855917457806 bayes_pls_golite062009
  • binding
    		•  1.83109253387887 bayes_pls_golite062009
  • exonuclease activity
    		•  1.68989335095363 bayes_pls_golite062009
  • exoribonuclease activity
    		•  1.41353777396851 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  1.33509846387956 bayes_pls_golite062009
  • transcription factor activity
    		•  1.17659544650821 bayes_pls_golite062009
  • chromatin binding
    		•  1.11900638060439 bayes_pls_golite062009
  • mismatch repair complex binding
    		•  1.10201551909695 bayes_pls_golite062009
  • damaged DNA binding
    		•  1.08077297289305 bayes_pls_golite062009
  • catalytic activity
    		•  1.04899053677564 bayes_pls_golite062009
  • 3'-5'-exoribonuclease activity
    		•  0.98331180621651 bayes_pls_golite062009
  • 3'-5' exonuclease activity
    		•  0.78558451404229 bayes_pls_golite062009
  • endoribonuclease activity, producing 5'-phosphomonoesters
    		•  0.708753843279937 bayes_pls_golite062009
  • MutLalpha complex binding
    		•  0.672116175206859 bayes_pls_golite062009
  • endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  0.598360955770972 bayes_pls_golite062009
    		• 0.49473250705373 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.433956339585542 bayes_pls_golite062009
  • protein binding
    		•  0.354190470641287 bayes_pls_golite062009
  • nuclease activity
    		•  0.332024848299731 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.283883977748512 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.228341362435973 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.206750180223289 bayes_pls_golite062009
  • single-stranded DNA specific exodeoxyribonuclease activity
    		•  0.19596408995795 bayes_pls_golite062009
  • 5'-3' exonuclease activity
    		•  0.154583332107704 bayes_pls_golite062009
  • transcription activator activity
    		•  0.104967281174106 bayes_pls_golite062009
  • endoribonuclease activity
    		•  0.016619833072142 bayes_pls_golite062009
    2
    Term Confidence Notes
  • DNA-directed DNA polymerase activity
    		•  10.6911520838834 bayes_pls_golite062009
  • DNA polymerase activity
    		•  10.645713605123 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  8.39147983801981 bayes_pls_golite062009
  • DNA primase activity
    		•  6.94341770434315 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.49699229430126 bayes_pls_golite062009
  • transferase activity
    		•  3.80228208941612 bayes_pls_golite062009
  • DNA binding
    		•  2.64619844447089 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.6018293992859 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  2.53877834217178 bayes_pls_golite062009
  • DNA-directed RNA polymerase activity
    		•  2.39159655026329 bayes_pls_golite062009
  • RNA polymerase activity
    		•  2.39159655026329 bayes_pls_golite062009
  • binding
    		•  1.84871443682239 bayes_pls_golite062009
  • exonuclease activity
    		•  1.38951646742998 bayes_pls_golite062009
  • catalytic activity
    		•  0.985794797454925 bayes_pls_golite062009
  • damaged DNA binding
    		•  0.903519456111979 bayes_pls_golite062009
  • chromatin binding
    		•  0.891218870764102 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.431057665208185 bayes_pls_golite062009
  • 3'-5' exonuclease activity
    		•  0.427833022898625 bayes_pls_golite062009
  • protein binding
    		•  0.366887851366715 bayes_pls_golite062009
  • nuclease activity
    		•  0.126991239633667 bayes_pls_golite062009
  • single-stranded DNA specific exodeoxyribonuclease activity
    		•  0.024241485627603 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.
    10 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle