| Protein: | DNApol-epsilon-PA |
| Organism: | Drosophila melanogaster |
| Length: | 2236 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DNApol-epsilon-PA.
| Description | E-value | Query Range |
Subject Range |
|
|
2453.0 | [0..1] | [2234..1] |
|
Region A: Residues: [1-819] |
1 11 21 31 41 51
| | | | | |
1 MSDSSKGKVL QNTGKFVSEN RTEGDDFFNE AGYRQSREND KIDSKYGFDR VKDSQERTGY 60
61 LINMHSNEVL DEDRRLIAAL DLFFIQMDGS RFKCTVAYQP YLLIRPEDNM HLEVARFLGR 120
121 KYSGQISGLE HITKEDLDLP NHLSGLQQQY IKLSFLNQTA MTKVRRELMS AVKRNQERQK 180
181 SNTYYMQMLA TSLAQSSAGS EDATLGKRQQ DYMDCIVDIR EHDVPYHVRV SIDLRIFCGQ 240
241 WYNIRCRSGV ELPTITCRPD ILDRPEPVVL AFDIETTKLP LKFPDAQTDQ VMMISYMIDG 300
301 QGYLITNREI ISSNVDDFEY TPKPEFEGNF IVFNEENEMQ LLQRFFDHIM EVRPHIIVTY 360
361 NGDFFDWPFV ETRAAVYDLD MKQEIGFSKL RDGNYLSRPA IHMDCLCWVK RDSYLPVGSQ 420
421 GLKAVAKAKL RYDPVELDPE DMCRMAVEQP QVLANYSVSD AVATYYLYMK YVHPFIFALN 480
481 TIIPMEPDEI LRKGSGTLCE TLLMVEAYHA QIVYPNKHQS ELNKLSNEGH VLDSETYVGG 540
541 HVEALESGVF RADIPCRFRL DPAMVKQLQE QVDAVLRHAI EVEEGIPLEK VLNLDEVRQE 600
601 IVQGLQGLHD IPNRLEQPVI YHLDVGAMYP NIILTNRLQP SAMVSDLDCA ACDFNKPGVR 660
661 CKRSMDWLWR GEMLPASRNE FQRIQQQLET EKFPPLFPGG PQRAFHELSK EDQAAYEKKR 720
721 LTDYCRKAYK KTKLTKLETR TSTICQKENS FYVDTVRAFR DRRYEYKGLT KVAKASVNAA 780
781 VASGDAAEIK AAKGREVLYD SLQLAHKCIL NSFYGYVMR
|
| Detection Method: |  |
| Confidence: | 98.69897 |
| Match: | 1tgoA |
| Description: | Exonuclease domain of family B (archaeal and phage) DNA polymerases; T4-like DNA polymerase |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| DNA-directed DNA polymerase activity | 11.2781960093187 | bayes_pls_golite062009 |
| DNA polymerase activity | 11.2285838712952 | bayes_pls_golite062009 |
| nucleotidyltransferase activity | 8.85826259809475 | bayes_pls_golite062009 |
| DNA primase activity | 7.3506495327575 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 4.79232184185512 | bayes_pls_golite062009 |
| endonuclease activity | 4.4589129578563 | bayes_pls_golite062009 |
| endodeoxyribonuclease activity | 4.26114862034453 | bayes_pls_golite062009 |
| transferase activity | 4.02382113115178 | bayes_pls_golite062009 |
| DNA binding | 2.71295423886311 | bayes_pls_golite062009 |
| RNA polymerase activity | 2.69726786045171 | bayes_pls_golite062009 |
| DNA-directed RNA polymerase activity | 2.69726786045171 | bayes_pls_golite062009 |
| ribonuclease activity | 2.66669472409706 | bayes_pls_golite062009 |
| nucleic acid binding | 2.64264099197997 | bayes_pls_golite062009 |
| deoxyribonuclease activity | 2.58611070700103 | bayes_pls_golite062009 |
| transcription regulator activity | 2.20855917457806 | bayes_pls_golite062009 |
| binding | 1.83109253387887 | bayes_pls_golite062009 |
| exonuclease activity | 1.68989335095363 | bayes_pls_golite062009 |
| exoribonuclease activity | 1.41353777396851 | bayes_pls_golite062009 |
| exoribonuclease activity, producing 5'-phosphomonoesters | 1.33509846387956 | bayes_pls_golite062009 |
| transcription factor activity | 1.17659544650821 | bayes_pls_golite062009 |
| chromatin binding | 1.11900638060439 | bayes_pls_golite062009 |
| mismatch repair complex binding | 1.10201551909695 | bayes_pls_golite062009 |
| damaged DNA binding | 1.08077297289305 | bayes_pls_golite062009 |
| catalytic activity | 1.04899053677564 | bayes_pls_golite062009 |
| 3'-5'-exoribonuclease activity | 0.98331180621651 | bayes_pls_golite062009 |
| 3'-5' exonuclease activity | 0.78558451404229 | bayes_pls_golite062009 |
| endoribonuclease activity, producing 5'-phosphomonoesters | 0.708753843279937 | bayes_pls_golite062009 |
| MutLalpha complex binding | 0.672116175206859 | bayes_pls_golite062009 |
| endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters | 0.598360955770972 | bayes_pls_golite062009 |
| 0.49473250705373 | bayes_pls_golite062009 | |
| structure-specific DNA binding | 0.433956339585542 | bayes_pls_golite062009 |
| protein binding | 0.354190470641287 | bayes_pls_golite062009 |
| nuclease activity | 0.332024848299731 | bayes_pls_golite062009 |
| DNA helicase activity | 0.283883977748512 | bayes_pls_golite062009 |
| general RNA polymerase II transcription factor activity | 0.228341362435973 | bayes_pls_golite062009 |
| single-stranded DNA binding | 0.206750180223289 | bayes_pls_golite062009 |
| single-stranded DNA specific exodeoxyribonuclease activity | 0.19596408995795 | bayes_pls_golite062009 |
| 5'-3' exonuclease activity | 0.154583332107704 | bayes_pls_golite062009 |
| transcription activator activity | 0.104967281174106 | bayes_pls_golite062009 |
| endoribonuclease activity | 0.016619833072142 | bayes_pls_golite062009 |
|
Region A: Residues: [820-1139] |
1 11 21 31 41 51
| | | | | |
1 RGARWHSMPM AGIVCLTGSN IITKAREIIE RVGRPLELDT DGIWCILPGS FPQEFTIHTS 60
61 HEKKKKINIS YPNAVLNTMV KDHFTNDQYH ELRKDKENNL PKYDIRDENS IFFEVDGPYL 120
121 AMVLPAAKEE GKKLKKRYAV FNFDGTLAEL KGFEVKRRGE LQLIKNFQSS VFEAFLAGST 180
181 LEECYASVAK VADYWLDVLY SRGSNLPDSE LFELISENKS MSKKLEEYGA QKSTSISTAK 240
241 RLAEFLGEQM VKDAGLACKY IISKKPEGAP VTERAIPLAI FQSEPSVRRH HLRRWLKDNT 300
301 MGDADIRDVL DWNYYIERLG
|
| Detection Method: | |
| Confidence: | 4.18 |
| Match: | 1q8iA |
| Description: | Crystal structure of ESCHERICHIA coli DNA Polymerase II |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| DNA-directed DNA polymerase activity | 10.6911520838834 | bayes_pls_golite062009 |
| DNA polymerase activity | 10.645713605123 | bayes_pls_golite062009 |
| nucleotidyltransferase activity | 8.39147983801981 | bayes_pls_golite062009 |
| DNA primase activity | 6.94341770434315 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 4.49699229430126 | bayes_pls_golite062009 |
| transferase activity | 3.80228208941612 | bayes_pls_golite062009 |
| DNA binding | 2.64619844447089 | bayes_pls_golite062009 |
| nucleic acid binding | 2.6018293992859 | bayes_pls_golite062009 |
| deoxyribonuclease activity | 2.53877834217178 | bayes_pls_golite062009 |
| DNA-directed RNA polymerase activity | 2.39159655026329 | bayes_pls_golite062009 |
| RNA polymerase activity | 2.39159655026329 | bayes_pls_golite062009 |
| binding | 1.84871443682239 | bayes_pls_golite062009 |
| exonuclease activity | 1.38951646742998 | bayes_pls_golite062009 |
| catalytic activity | 0.985794797454925 | bayes_pls_golite062009 |
| damaged DNA binding | 0.903519456111979 | bayes_pls_golite062009 |
| chromatin binding | 0.891218870764102 | bayes_pls_golite062009 |
| structure-specific DNA binding | 0.431057665208185 | bayes_pls_golite062009 |
| 3'-5' exonuclease activity | 0.427833022898625 | bayes_pls_golite062009 |
| protein binding | 0.366887851366715 | bayes_pls_golite062009 |
| nuclease activity | 0.126991239633667 | bayes_pls_golite062009 |
| single-stranded DNA specific exodeoxyribonuclease activity | 0.024241485627603 | bayes_pls_golite062009 |
|
Region A: Residues: [1140-1240] |
1 11 21 31 41 51
| | | | | |
1 GTIQKIITIP AALQGLANPV PRVQHPDWLH KKMLEKNDVL KQRRINEMFT SRPKPKPLAT 60
61 EEDKLADMED LAGKDGGEGA AGCPIVTKRK RIQLEEHDDE E
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [1241-1417] |
1 11 21 31 41 51
| | | | | |
1 AQPQATTWRQ ALGAPPPIGE TRKTIVEWVR FQKKKWKWQQ DQRQRNRQAS KRTRGEDPPV 60
61 VRATGSTATL GGFLRRAQRT LLDQPWQIVQ LVPVDDLGHF TVWALIGEEL HKIKLTVPRI 120
121 FYVNQRSAAP PEEGQLWRKV NRVLPRSRPV FNLYRYSVPE QLFRDNSLGM LADLATP
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [1418-1495] |
1 11 21 31 41 51
| | | | | |
1 DIEGIYETQM TLEFRALMDM GCICGVQREE ARRLAQLATK DLETFSIEQL EQRPQTQVKY 60
61 LASANNRLRK IYLYQHNT
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [1496-1596] |
1 11 21 31 41 51
| | | | | |
1 PTAKKEIWSL ILMPSKKAFV FALDTVRANQ MPNMRQLYTA ERLALLKNLT AEEQDKIPVE 60
61 DYTFEVLIEV DVKQIYRHIQ RALTTYKQEH QGPTILCLQT A
|
| Detection Method: | |
Shown below is our most confident prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [1597-1754] |
1 11 21 31 41 51
| | | | | |
1 LSARKLSLAM PILLEFPQAE IHISDDASLL SGLDWQRQGS RAVIRHFLNL NNVLDLMLDQ 60
61 CRYFHVPIGN MPPDTVLFGA DLFFARLLQR HNFVLWWSAS TRPDLGGREA DDSRLLAEFE 120
121 ESISVVQNKA GFYPDVCVEL ALDSLAVSAL LQSTRIQE
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [1755-1924] |
1 11 21 31 41 51
| | | | | |
1 MEGASSAITF DVMPQVSLEE MIGTVPAATL PSYDETALCS AAFRVMRSMV NGWLREVSIN 60
61 RNIFSDFQIV HFYRWVRSSN ALLYDPALRR SLNNLMRKMF LRIIAEFKRL GATIIYADFN 120
121 RIILSSGKKT VSDALGYVDY IVQSLRNKEM FHSIQLSFEQ CWNFMLWMDQ
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [1925-2136] |
1 11 21 31 41 51
| | | | | |
1 ANFSGIRGKL PKGIDETVSS IVSTTMIRDS ERNQDDDEDE EEDSENRDPV ESNEAEQDQE 60
61 DELSLELNWT IGEHLPDENE CREKFESLLT LFMQSLAEKK TTEQAIKDIS HCAFDFILKL 120
121 HKNYGKGKPS PGLELIRTLI KALSVDKTLA EQINELRRNM LRLVGIGEFS DLAEWEDPCD 180
181 SHIINEVICK ACNHCRDLDL CKDKHRAMKD GV
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [2137-2236] |
1 11 21 31 41 51
| | | | | |
1 PVWLCAQCYV AYDNEEIEMR MLDALQRKMM SYVLQDLRCS RCSEIKRENL AEFCTCAGNF 60
61 VPLISGKDIQ TLLGTFNKVA ANHKMQLLQQ TVHQALTTPR
|
| Detection Method: | |
Shown below is our most confident prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
