Protein Overview: E2f-PA, E2f-PC, ...

General Information:
Name(s) found:	FBpp0311985 [FlyBase] E2f-PA / FBpp0083518 [FlyBase] E2f-PC / FBpp0083517 [FlyBase] E2f-PB / FBpp0083516 [FlyBase]
Description(s) found: Found 58 descriptions. SHOW ALL	type=protein; loc=3R:complement(17447291..17447418,17448534..17449373,17449561..17449807,17450887..17451615,17451746..17452219); ID=FBpp0311985; name=E2f-PF; parent=FBgn0011766,FBtr0346157; dbxref=FlyBase:FBpp0311985,FlyBase_Annotation_IDs:CG6376-PF; MD5=f12a8f7e37e61f78db98cfad3ee2364c; length=805; release=r5.56; species=Dmel; [FlyBase] The gene E2F transcription factor is referred to in FlyBase by the symbol Dmel\E2f (CG6376, FBgn0011766). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:17446026..17486127. It has the cytological map location 93E9-93F1. There is experimental evidence that it has the molecular function</span>: protein binding; RNA polymerase II transcription factor activity; DNA binding. There is experimental evidence that it is involved in the biological process</span>: positive regulation of gene expression; cellular process; dendrite morphogenesis; neuron development; positive regulation of nurse cell apoptosis; muscle tissue development; antimicrobial humoral response; regulation of cell cycle; DNA endoreduplication. 68 alleles are reported. The phenotypes of these alleles are annotated with 28 unique terms, many of which group under: organ system; peripheral nervous system; nervous system; external compound sense organ; female germline cyst; egg; imaginal precursor; cell part; primordium; larval imaginal precursor. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase] The gene E2F transcription factor is referred to in FlyBase by the symbol Dmel\E2f (CG6376, FBgn0011766). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:17446026..17486127. It has the cytological map location 93E9-93F1. There is experimental evidence that it has the molecular function</span>: protein binding; RNA polymerase II transcription factor activity; DNA binding. There is experimental evidence that it is involved in the biological process</span>: positive regulation of gene expression; cellular process; dendrite morphogenesis; neuron development; positive regulation of nurse cell apoptosis; muscle tissue development; antimicrobial humoral response; regulation of cell cycle; DNA endoreduplication. 68 alleles are reported. The phenotypes of these alleles are annotated with 28 unique terms, many of which group under: organ system; peripheral nervous system; nervous system; external compound sense organ; female germline cyst; egg; imaginal precursor; cell part; primordium; larval imaginal precursor. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase] The gene E2F transcription factor is referred to in FlyBase by the symbol Dmel\E2f (CG6376, FBgn0011766). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:17446026..17486127. It has the cytological map location 93E9-93F1. There is experimental evidence that it has the molecular function</span>: protein binding; RNA polymerase II transcription factor activity; DNA binding. There is experimental evidence that it is involved in the biological process</span>: positive regulation of gene expression; cellular process; dendrite morphogenesis; neuron development; positive regulation of nurse cell apoptosis; muscle tissue development; antimicrobial humoral response; regulation of cell cycle; DNA endoreduplication. 68 alleles are reported. The phenotypes of these alleles are annotated with 28 unique terms, many of which group under: organ system; peripheral nervous system; nervous system; external compound sense organ; female germline cyst; egg; imaginal precursor; cell part; primordium; larval imaginal precursor. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	805 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA][NAS] Rb-E2F complex [IDA]
Biological Process:	positive regulation of cell proliferation [NAS] DNA endoreduplication [IGI][IMP] imaginal disc development [TAS] positive regulation of transcription [TAS] regulation of transcription, DNA-dependent [IEA] muscle tissue development [IMP] positive regulation of nurse cell apoptosis [IMP] nurse cell apoptosis [TAS] neuron development [IMP] growth [NAS] cellular process [IMP] dendrite morphogenesis [IMP] eggshell chorion gene amplification [TAS] regulation of transcription involved in G1/S-phase of mitotic cell cycle [NAS] positive regulation of gene expression [IMP] G1/S transition of mitotic cell cycle [TAS] regulation of cell cycle [IMP][NAS] antimicrobial humoral response [IMP]
Molecular Function:	DNA binding [IDA] transcription factor activity [IEA] protein binding [IPI] RNA polymerase II transcription factor activity [IDA][NAS] transcription activator activity [TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKFFVNVAP INNSNSSSSH TTTSSNTQRH QQHQQHYGGS GTTGHTMVAR RLNYDLHGGT  60
   61 TSINNNNNIV IKNESVDLDY DHVLSSSDSN SNGGVAAHLR DHVYISLDKG HNTGAVATAA 120
  121 AAATAGHTQQ QLQQQHHHQN QQQRKATGKS NDITNYYKVK RRPHAVSDEI HPKKQAKQSA 180
  181 HHQTVYQKHT ASSAPQQLRH SHHQLRHDAD AELDEDVVER VAKPASHHPF SLSTPQQQLA 240
  241 ASVASSSSSG DRNRADTSLG ILTKKFVDLL QESPDGVVDL NEASNRLHVQ KRRIYDITNV 300
  301 LEGINILEKK SKNNIQWRCG QSMVSQERSR HIEADSLRLE QQENELNKAI DLMRENLAEI 360
  361 SQEVENSGGM AYVTQNDLLN VDLFKDQIVI VIKAPPEAKL VLPNTKLPRE IYVKAENSGE 420
  421 INVFLCHDTS PENSPIAPGA GYVGAPGAGC VRTATSTRLH PLTNQRLNDP LFNNIDAMST 480
  481 KGLFQTPYRS ARNLSKSIEE AAKQSQPEYN NICDIAMGQH HNLNQQQQQQ QQQLLQQPEE 540
  541 DDVDVELNQL VPTLTNPVVR THQFQQHQQP SIQELFSSLT ESSPPTPTKR RREAAAAAIA 600
  601 AGSSTTATTT LNSHNNRNHS NHSNHSNHSS SNNSKSQPPT IGYGSSQRRS DVPMYNCAME 660
  661 GATTTSATAD TTAATSRSAA ASSLQMQFAA VAESNNGSSS GGGGGGGGYG SIAGAGANAD 720
  721 PHQPYSHDRN SLPPGVADCD ANSNSSSVTL QGLDALFNDI GSDYFSNDIA FVSINPPDDN 780
  781 DYPYALNANE GIDRLFDFGS DAYGP

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..191]	deduced	N/A	No confident structure predictions are available.
2	View Details	[192..312]	PSI-BLAST	26.0	Cell cycle transcription factor E2F-4
3	View Details	[313..487]	PSI-BLAST	22.69897	Structure of the Rb C-terminal domain bound to an E2F1-DP1 heterodimer
4	View Details	[488..560]	deduced	N/A	No confident structure predictions are available.
5	View Details	[561..805]	MSA	5.129996	View MSA. No confident structure predictions are available.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.90

Protein Overview: E2f-PA, E2f-PC, ...

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: