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Protein Overview: FBpp0310647, Sir...

General Information:
Name(s) found: FBpp0310647 [FlyBase]
Sirt2-PA / FBpp0083290 [FlyBase]
Description(s) found:
Found 28 descriptions.
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  • type=protein; loc=3R:join(16154459..16154542,16154599..16154695,16154751..16155637); ID=FBpp0310647; name=Sirt2-PB; parent=FBgn0038788,FBtr0344243; dbxref=FlyBase:FBpp0310647,FlyBase_Annotation_IDs:CG5085-PB; MD5=f9cc21c8f8ca5a073822e48dc91c6836; length=355; release=r5.56; species=Dmel; [FlyBase]
  • The gene Sirt2 is referred to in FlyBase by the symbol Dmel\Sirt2 (CG5085, FBgn0038788). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:16154192..16155751. It has the cytological map location 92E3. There is experimental evidence that it has the molecular function</span>: NAD-dependent histone deacetylase activity. There is experimental evidence that it is involved in the biological process</span>: determination of adult lifespan; dendrite morphogenesis; protein amino acid deacetylation. 7 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 355 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: determination of adult lifespan [IMP]
    protein amino acid deacetylation [IDA]
    chromatin silencing [IEA]
    regulation of transcription [IEA]
    dendrite morphogenesis [IMP]
    Molecular Function: zinc ion binding [IEA]
    NAD-dependent histone deacetylase activity [IDA][ISS]
    NAD binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDKVRRFFAN TLHLGGSSDA KEEVKVEKVI PDLSFDGFAE HWRVHGFRKI VTMVGAGIST  60
   61 SAGIPDFRSP GSGLYSNLKK YELPHPTAIF DLDYFEKNPA PFFALAKELY PGSFIPTPAH 120
  121 YFIRLLNDKG LLQRHYTQNI DTLDRLTGLP EDKIIEAHGS FHTNHCIKCR KEYDMDWMKA 180
  181 EIFADRLPKC QKCQGVVKPD IVFFGENLPK RFYSSPEEDF QDCDLLIIMG TSLEVQPFAS 240
  241 LVWRPGPRCI RLLINRDAVG QASCVLFMDP NTRSLLFDKP NNTRDVAFLG DCDAGVMALA 300
  301 KALGWDQELQ QLITSERKKL SGSQNSEELQ QGKEKPQSDP DKMTSGDRDK KDASL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..355] PSI-BLAST 91.69897 Sirt2 histone deacetylase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein deacetylase activity
    		•  9.15022242957651 bayes_pls_golite062009
  • histone deacetylase activity
    		•  9.04876491350231 bayes_pls_golite062009
  • NAD-dependent protein deacetylase activity
    		•  8.13038616303736 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity
    		•  8.13038616303736 bayes_pls_golite062009
  • deacetylase activity
    		•  8.11496387956068 bayes_pls_golite062009
  • histone deacetylase activity (H3-K14 specific)
    		•  6.02509672218091 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
    		•  5.83127897351395 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity (H3-K9 specific)
    		•  5.29340754009793 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity (H3-K14 specific)
    		•  5.29340754009793 bayes_pls_golite062009
  • tubulin deacetylase activity
    		•  4.98963898611597 bayes_pls_golite062009
  • NAD+ ADP-ribosyltransferase activity
    		•  4.62921662347995 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity (H4-K16 specific)
    		•  4.51070381823692 bayes_pls_golite062009
  • histone deacetylase activity (H3-K9 specific)
    		•  3.4896257195243 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.9155913558118 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  2.82468859281133 bayes_pls_golite062009
  • DNA binding
    		•  2.43141001866996 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.41433477472968 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.24657784428979 bayes_pls_golite062009
  • binding
    		•  2.06552694538163 bayes_pls_golite062009
  • histone binding
    		•  1.71445510915336 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.64212790017753 bayes_pls_golite062009
  • protein binding
    		•  1.52593340148652 bayes_pls_golite062009
  • nucleosome binding
    		•  1.5125174755597 bayes_pls_golite062009
  • hydrolase activity
    		•  1.43067365161346 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  1.40719303660557 bayes_pls_golite062009
  • transcription factor activity
    		•  1.30143289828088 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  1.26370407179255 bayes_pls_golite062009
  • transcription factor binding
    		•  1.14766678956419 bayes_pls_golite062009
  • NAD(P)+-protein-arginine ADP-ribosyltransferase activity
    		•  0.963519974868694 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  0.74741958699764 bayes_pls_golite062009
  • catalytic activity
    		•  0.739210399081789 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.56434127203174 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.54005617175343 bayes_pls_golite062009
  • transferase activity
    		•  0.483523935618287 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.66

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle