YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: FBpp0310647, Sir...
Organism: Drosophila melanogaster
Length: 355 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FBpp0310647, Sir....

Description E-value Query
Range
Subject
Range
SIR2_DANRE - NAD-dependent protein deacetylase sirtuin-2 OS=Danio rerio GN=sirt2 PE=2 SV=1
356.0 [0..1] [352..37]

Back

Predicted Domain #1
Region A:
Residues: [1-355]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDKVRRFFAN TLHLGGSSDA KEEVKVEKVI PDLSFDGFAE HWRVHGFRKI VTMVGAGIST  60
   61 SAGIPDFRSP GSGLYSNLKK YELPHPTAIF DLDYFEKNPA PFFALAKELY PGSFIPTPAH 120
  121 YFIRLLNDKG LLQRHYTQNI DTLDRLTGLP EDKIIEAHGS FHTNHCIKCR KEYDMDWMKA 180
  181 EIFADRLPKC QKCQGVVKPD IVFFGENLPK RFYSSPEEDF QDCDLLIIMG TSLEVQPFAS 240
  241 LVWRPGPRCI RLLINRDAVG QASCVLFMDP NTRSLLFDKP NNTRDVAFLG DCDAGVMALA 300
  301 KALGWDQELQ QLITSERKKL SGSQNSEELQ QGKEKPQSDP DKMTSGDRDK KDASL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 91.69897
Match: 1j8fA
Description: Sirt2 histone deacetylase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein deacetylase activity 9.15022242957651 bayes_pls_golite062009
histone deacetylase activity 9.04876491350231 bayes_pls_golite062009
NAD-dependent protein deacetylase activity 8.13038616303736 bayes_pls_golite062009
NAD-dependent histone deacetylase activity 8.13038616303736 bayes_pls_golite062009
deacetylase activity 8.11496387956068 bayes_pls_golite062009
histone deacetylase activity (H3-K14 specific) 6.02509672218091 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 5.83127897351395 bayes_pls_golite062009
NAD-dependent histone deacetylase activity (H3-K9 specific) 5.29340754009793 bayes_pls_golite062009
NAD-dependent histone deacetylase activity (H3-K14 specific) 5.29340754009793 bayes_pls_golite062009
tubulin deacetylase activity 4.98963898611597 bayes_pls_golite062009
NAD+ ADP-ribosyltransferase activity 4.62921662347995 bayes_pls_golite062009
NAD-dependent histone deacetylase activity (H4-K16 specific) 4.51070381823692 bayes_pls_golite062009
histone deacetylase activity (H3-K9 specific) 3.4896257195243 bayes_pls_golite062009
transcription regulator activity 2.9155913558118 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 2.82468859281133 bayes_pls_golite062009
DNA binding 2.43141001866996 bayes_pls_golite062009
nucleic acid binding 2.41433477472968 bayes_pls_golite062009
transcription repressor activity 2.24657784428979 bayes_pls_golite062009
binding 2.06552694538163 bayes_pls_golite062009
histone binding 1.71445510915336 bayes_pls_golite062009
transcription corepressor activity 1.64212790017753 bayes_pls_golite062009
protein binding 1.52593340148652 bayes_pls_golite062009
nucleosome binding 1.5125174755597 bayes_pls_golite062009
hydrolase activity 1.43067365161346 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 1.40719303660557 bayes_pls_golite062009
transcription factor activity 1.30143289828088 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 1.26370407179255 bayes_pls_golite062009
transcription factor binding 1.14766678956419 bayes_pls_golite062009
NAD(P)+-protein-arginine ADP-ribosyltransferase activity 0.963519974868694 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 0.74741958699764 bayes_pls_golite062009
catalytic activity 0.739210399081789 bayes_pls_golite062009
cation transmembrane transporter activity 0.56434127203174 bayes_pls_golite062009
transcription cofactor activity 0.54005617175343 bayes_pls_golite062009
transferase activity 0.483523935618287 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle