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Protein Overview: FBpp0302531

General Information:
Name(s) found: FBpp0302531 [FlyBase]
Description(s) found:
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  • gi|62472685|ref|NP_001014635.1| Rpb4, isoform A [Drosophila melanogaster] [NCBI NR]
  • ref|NP_650700.2| CG31318-PA [Drosophila melanogaster] [NCBI NR]
  • gi|23171620|gb|AAN13767.1| Rpb4, isoform A [Drosophila melanogaster] [NCBI NR]
  • type=protein; loc=3R:complement(14079276..14080038,14080097..14080913,14081039..14081102); ID=FBpp0302531; name=Ada2a-PA; parent=FBgn0263738,FBtr0310380; dbxref=FlyBase:FBpp0302531,FlyBase_Annotation_IDs:CG43663-PA,REFSEQ:NP_001014635,GB_protein:AAN13767; MD5=f30c652e3cc30da9f97ef9f0dbc2858d; length=547; release=r5.56; species=Dmel; [FlyBase]
  • The gene Rpb4 is referred to in FlyBase by the symbol Dmel\Rpb4 (CG33520, FBgn0053520). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:14078565..14081191. It has the cytological map location 90F10-90F11. There is experimental evidence that it has the molecular function</span>: protein binding; DNA-directed RNA polymerase activity. There is experimental evidence that it is involved in the biological process</span>: histone H3 acetylation; cell proliferation; mRNA transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; regulation of histone acetylation. 5 alleles are reported. No phenotypic data is available. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
  • >CG31318-PA translation from_gene[CG31318 Ada2A FBgn0051318] seq_release:3 mol_weight=63968 cds_boundaries:(3R:14,079,295..14,081,118[-]) aa_length:547 transcript_info:[CG31318-RA seq_release:3] gene_info:[gene symbol:Ada2A synonyms:[CG7150] FBgn005131 [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q8IN85) CG31318-PA [DrosMelano7227.FASTAC.txt]
  • CG31318-PA, isoform A [Drosophila melanogaster]gi|24647899|ref|NP_650700.2| CG31318-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3R:complement(14079276..14080038,14080097..14080913,14081039..14081102); ID=FBpp0083024; name=Rpb4-PA; parent=FBgn0053520,FBtr0083604; dbxref=FlyBase_Annotation_IDs:CG33520-PA,FlyBase:FBpp0083024,GB_protein:AAN13767.1,REFSEQ:NP_001014635 [fly-100309-contam.fasta]
  • CG33520-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Rpb4 CG33520-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=3R:complement(14079276..14080038,14080097..14080913,14081039..14081102); ID=FBpp0083024; name=Rpb4-PA; parent=FBgn0053520,FBtr0083604; dbxref=FlyBase_Annotation_IDs:CG33520-PA,FlyBase:FBpp0083024,GB_protein:AAN13767.1,REFSEQ:NP_001014635,GB_protein:AAN13767; MD5=f30c652e3cc30da9f97ef9f0dbc2858d; length=547; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:complement(14079276..14080038,14080097..14080913,14081039..14081102); ID=FBpp0083024; name=Rpb4-PA; parent=FBgn0053520,FBtr0083604; dbxref=FlyBase_Annotation_IDs:CG33520-PA,FlyBase:FBpp0083024,GB_protein:AAN13767.1,REFSEQ:NP_001014635,GB_protein:AAN13767; MD5=f30c652e3cc30da9f97ef9f0dbc2858d; length=547; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Isoform A of Transcriptional adapter 2A OS=Drosophila melanogaster GN=Rpb4 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=3R:complement(14079276..14080038,14080097..14080913,14081039..14081102); ID=FBpp0302531; name=Ada2a-PA; parent=FBgn0263738,FBtr0310380; dbxref=FlyBase:FBpp0302531,FlyBase_Annotation_IDs:CG43663-PA; MD5=f30c652e3cc30da9f97ef9f0dbc2858d; length=547; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=3R:complement(join(18255317..18255380,18254375..18255191,18253554..18254316)); ID=FBpp0302531; name=Ada2a-PA; parent=FBgn0263738,FBtr0310380; dbxref=FlyBase:FBpp0302531,FlyBase_Annotation_IDs:CG43663-PA,REFSEQ:NP_001014635,GB_protein:AAN13767; MD5=f30c652e3cc30da9f97ef9f0dbc2858d; length=547; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3R:complement(join(18255317..18255380,18254375..18255191,18253554..18254316)); ID=FBpp0302531; name=Ada2a-PA; parent=FBgn0263738,FBtr0310380; dbxref=FlyBase:FBpp0302531,FlyBase_Annotation_IDs:CG43663-PA,REFSEQ:NP_001014635,GB_protein:AAN13767; MD5=f30c652e3cc30da9f97ef9f0dbc2858d; length=547; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Isoform of Q7KSD8, Isoform A of Transcriptional adapter 2A OS=Drosophila melanogaster GN=Rpb4 [DROME.fasta.20160308]
  • FBpp0302531 type=protein; loc=3R:complement(join(18255317..18255380,18254375..18255191,18253554..18254316)); ID=FBpp0302531; name=Ada2a-PA; parent=FBgn0263738,FBtr0310380; dbxref=FlyBase:FBpp0302531,FlyBase_Annotation_IDs:CG43663-PA,REFSEQ:NP_001014635,GB_protein:AAN13767; MD5=f30c652e3cc30da9f97ef9f0dbc2858d; length=547; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=3R:complement(join(18255317..18255380,18254375..18255191,18253554..18254316)); ID=FBpp0302531; name=Ada2a-PA; parent=FBgn0263738,FBtr0310380; dbxref=FlyBase:FBpp0302531,FlyBase_Annotation_IDs:CG43663-PA,REFSEQ:NP_001014635,GB_protein:AAN13767; MD5=f30c652e3cc30da9f97ef9f0dbc2858d; length=547; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 547 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFMNPVDMV DEDAADLQFP KVEPLGPQVK RFIHAHQNEH TRNSMVLYNP HTLHRYLEEM  60
   61 EEKTRDQNSS VPSATKDANR CATCRCSLTE PYIKCSECLD TLLCLQCFSR GKEAFSHRNN 120
  121 HAYIIVRDNI QVFADEPHWT ARDERILLKT LRTHGYGNWE AVSQALDQRH EPAEVRRHYH 180
  181 DCYFGGIFER LLNLKHARDS YVPERMPYVF KMRSLDPPRH DDIASMQFRL SAGYRCARGD 240
  241 FDTPYDTSAE SLLSIMVDHR GRDDDNEASE SEFEREVTEE LQLGLVRAYN NRLRERQRRY 300
  301 KIMRQHGLIM PNRTVSWISK YVHAFGSDAS CMRFLGFMQI CPDPIKFDML LESLRYYREL 360
  361 HSQLHKLYDL REHGVRTLSG AKLYARLSKE RQQAQRDYSR LKQTDAFDWQ QLVQHYESNR 420
  421 SGDPGPLAIN SKLYVMNTRR KASPIEIGGG KHFTHCLTPT EYNFSLIPDL PGYSKLDDGE 480
  481 RKLCSVARLV PQSYLDYKNQ LVTEQAKLGY LRLADARRLI KIDVNKTRQI YDFLLEHGHI 540
  541 SRPPSYG

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..75] PSI-BLAST 7.69897 Dystrophin
    2 View Details [76..126] FFAS03 2.28 No description for 2fc7A was found.
    3 View Details [127..211] MSA 1.296995 View MSA. No confident structure predictions are available.
    4 View Details [212..432] MSA 3.215992 View MSA. No confident structure predictions are available.
    5 View Details [433..547] PSI-BLAST 27.39794 Structural and functional analysis of ada2 alpha swirm domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transferase activity, transferring phosphorus-containing groups
    		•  3.8744900429978 bayes_pls_golite062009
  • acyltransferase activity
    		•  3.35050943544976 bayes_pls_golite062009
  • transferase activity, transferring acyl groups other than amino-acyl groups
    		•  3.31569325490599 bayes_pls_golite062009
  • transferase activity
    		•  3.23942674812578 bayes_pls_golite062009
  • binding
    		•  3.17556402087346 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  3.14878774301126 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.23156041569913 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.83723964306928 bayes_pls_golite062009
  • DNA binding
    		•  1.73924929536227 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.5869787076114 bayes_pls_golite062009
  • cation binding
    		•  1.19957754885754 bayes_pls_golite062009
  • metal ion binding
    		•  1.19957754885754 bayes_pls_golite062009
  • ion binding
    		•  1.19209803121473 bayes_pls_golite062009
  • protein binding
    		•  1.16246005294206 bayes_pls_golite062009
  • structural molecule activity
    		•  0.800850121197479 bayes_pls_golite062009
  • actin binding
    		•  0.637627956875516 bayes_pls_golite062009
  • motor activity
    		•  0.35554808768187 bayes_pls_golite062009
  • structural constituent of muscle
    		•  0.17143283003031 bayes_pls_golite062009
    2
    Term Confidence Notes
  • general RNA polymerase II transcription factor activity
    		•  5.89167912663142 bayes_pls_golite062009
  • binding
    		•  2.70912934275371 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.69310847474187 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.31493818053907 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  2.19099740571398 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  2.07850206021921 bayes_pls_golite062009
  • DNA binding
    		•  2.0126776192216 bayes_pls_golite062009
  • protein binding
    		•  1.48593945455888 bayes_pls_golite062009
  • transcription factor activity
    		•  1.23220438818624 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  1.21656984446301 bayes_pls_golite062009
  • transcription factor binding
    		•  0.987482369490121 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.876703944945945 bayes_pls_golite062009
  • ligase activity
    		•  0.497586458390942 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.283643164965801 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.190105232754922 bayes_pls_golite062009
  • catalytic activity
    		•  0.168711389690753 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.137379573046724 bayes_pls_golite062009
  • transcription activator activity
    		•  0.111490592727037 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • lysine N-acetyltransferase activity
    		•  5.80609397811031 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  5.80609397811031 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  5.49431089902672 bayes_pls_golite062009
  • transcription regulator activity
    		•  5.13863038737912 bayes_pls_golite062009
  • DNA binding
    		•  4.66369707598026 bayes_pls_golite062009
  • N-acyltransferase activity
    		•  4.57418118498868 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.51452285155271 bayes_pls_golite062009
  • N-acetyltransferase activity
    		•  4.37954729923498 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.09369451338399 bayes_pls_golite062009
  • transcription factor activity
    		•  4.06706589695599 bayes_pls_golite062009
  • RNA polymerase activity
    		•  3.9883025551666 bayes_pls_golite062009
  • DNA-directed RNA polymerase activity
    		•  3.9883025551666 bayes_pls_golite062009
  • acetyltransferase activity
    		•  3.80908511328212 bayes_pls_golite062009
  • acyltransferase activity
    		•  3.35206890637362 bayes_pls_golite062009
  • transferase activity, transferring acyl groups other than amino-acyl groups
    		•  3.30532537006075 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.16896789933192 bayes_pls_golite062009
  • transferase activity
    		•  3.10582783156108 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  3.08442186629685 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  2.86344939956632 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.41271657675151 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.91962622287073 bayes_pls_golite062009
  • transcription activator activity
    		•  1.77700860354597 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.73068440195944 bayes_pls_golite062009
  • chromatin binding
    		•  1.68956710349366 bayes_pls_golite062009
  • transcription factor binding
    		•  1.40653841901929 bayes_pls_golite062009
  • protein deacetylase activity
    		•  1.23680480131205 bayes_pls_golite062009
  • histone deacetylase activity
    		•  1.18932416576802 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.84983974758882 bayes_pls_golite062009
  • protein binding
    		•  0.830419844171551 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.666799964992178 bayes_pls_golite062009
  • histone binding
    		•  0.557787598121402 bayes_pls_golite062009
  • deacetylase activity
    		•  0.530687254192222 bayes_pls_golite062009
  • telomeric DNA binding
    		•  0.284650049512347 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.2679415219517 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.25931464844298 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.236060274498333 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.187022204923867 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.105174598157041 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle