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Protein Overview: Abd-B-PB

General Information:
Name(s) found: Abd-B-PB / FBpp0082826 [FlyBase]
Description(s) found:
Found 26 descriptions.
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  • The gene Abdominal B is referred to in FlyBase by the symbol Dmel\Abd-B (CG11648, FBgn0000015). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:12752932..12797958. It has the cytological map location 89E4-89E5. There is experimental evidence that it has the molecular function</span>: transcription factor activity. There is experimental evidence for 15 unique biological process</span> terms, many of which group under: anatomical structure development; organ development; reproductive process in a multicellular organism; regulation of developmental process; open tracheal system development; development of primary male sexual characteristics; genital disc development; regulation of biological process; segment specification; gonadal mesoderm development; system development. 205 alleles are reported. The phenotypes of these alleles are annotated with 105 unique terms, many of which group under: organ system; adult segment; abdominal ventral denticle belt; spiracle; thoracic segment; adult mesothoracic segment; peripheral nervous system; abdominal segment 7; embryonic abdomen; integumentary specialisation. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 493 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEA][NAS]
    Biological Process: negative regulation of salivary gland boundary specification [TAS]
    midgut development [TAS]
    male gonad development [IMP]
    external genitalia morphogenesis [IMP]
    genital disc sexually dimorphic development [IMP]
    salivary gland development [NAS]
    regulation of transcription [IEA]
    negative regulation of striated muscle tissue development [IMP]
    negative regulation of cardioblast cell fate specification [IMP]
    gonadal mesoderm development [IMP]
    developmental pigmentation [NAS]
    heart development [NAS]
    positive regulation of developmental pigmentation [NAS]
    sex differentiation [NAS]
    female genitalia development [IMP]
    genital disc development [TAS]
    spiracle morphogenesis, open tracheal system [IMP]
    pole cell migration [TAS]
    anterior/posterior axis specification, embryo [NAS]
    specification of segmental identity, abdomen [IMP][NAS]
    imaginal disc-derived genitalia development [TAS]
    regulation of transcription, DNA-dependent [IEA]
    germ cell migration [IMP][TAS]
    imaginal disc-derived female genitalia development [IMP]
    open tracheal system development [IMP]
    gonad development [NAS]
    male genitalia development [IMP]
    genital disc anterior/posterior pattern formation [IEP]
    determination of genital disc primordium [IMP]
    sex-specific pigmentation [TAS]
    Molecular Function: transcription factor activity [IDA]
    specific RNA polymerase II transcription factor activity [NAS]
    sequence-specific DNA binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQQHHLQQQQ QQQQQQEQQH LQEQQQHLQQ LHHHAHHHLP QPLHTTSHHH SAHPHLQQQQ  60
   61 QQQQHAVVAS SPSSVLQQQQ QQSTPTTHST PTHAVMYEDP PPVPLVAVQQ QHLPAPQQQQ 120
  121 QLQQQQQQQQ QQLATTPVAG ALSPAQTPTG PSAQQQQHLT SPHHQQLPQQ QTPNSVASGA 180
  181 SSNLQQQQQQ QNAAVAPGQT QIVAPTTASV SPSSVSSQKE DINMSIQLAP LHIPAIRAGP 240
  241 GFETDTSAAV KRHTAHWAYN DEGFNQHYGS GYYDRKHMFA YPYPETQFPV GQYWGPNYRP 300
  301 DQTTSAAAAA AYMNEAERHV SAAARQSVEG TSTSSYEPPT YSSPGGLRGY PSENYSSSGA 360
  361 SGGLSVGAVG PCTPNPGLHE WTGQVSVRKK RKPYSKFQTL ELEKEFLFNA YVSKQKRWEL 420
  421 ARNLQLTERQ VKIWFQNRRM KNKKNSQRQA NQQNNNNNSS SNHNHAQATQ QHHSGHHLNL 480
  481 SLNMGHHAAK MHQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..142] PSI-BLAST 4.522879 Sec24
    2 View Details [143..360] MSA 1.254995 View MSA. No confident structure predictions are available.
    3 View Details [361..493] PSI-BLAST 18.522879 Crystal Structure of HoxA9 and Pbx1 homeodomains bound to DNA

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  3.3573497204506 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • DNA binding
    		•  3.0205295442286 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.77547609431902 bayes_pls_golite062009
  • transcription factor activity
    		•  2.57014522504183 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.08714353704046 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.01558895662904 bayes_pls_golite062009
  • transcription activator activity
    		•  1.38536646126001 bayes_pls_golite062009
  • transcription factor binding
    		•  1.1887755957055 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.06075239560835 bayes_pls_golite062009
  • protein binding
    		•  0.830419844171551 bayes_pls_golite062009
  • chromatin binding
    		•  0.807185147096719 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.57338514991304 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.336563012956291 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle