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Protein Overview: ird5-PA

General Information:
Name(s) found: ird5-PA / FBpp0082690 [FlyBase]
Description(s) found:
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  • gi|48428497|sp|Q9VEZ5.2|IKKB_DROME RecName: Full=Inhibitor of nuclear factor kappa-B kinase subunit beta; Short=DmIKK-beta; AltName: Full=Immune response deficient protein 5; AltName: Full=IKK-like protein; AltName: Full=Lipopolysaccharide-activated kinas [NCBI NR]
  • gi|24647336|ref|NP_524751.2| immune response deficient 5 [Drosophila melanogaster] [NCBI NR]
  • gi|23171434|gb|AAF55267.2| immune response deficient 5 [Drosophila melanogaster] [NCBI NR]
  • Inhibitor of nuclear factor kappa-B kinase subunit beta OS=Drosophila melanogaster GN=ird5 PE=1 SV=2 [Swiss-Prot]
  • The gene immune response deficient 5 is referred to in FlyBase by the symbol Dmel\ird5 (CG4201, FBgn0024222). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:11872069..11875144. It has the cytological map location 89B1. There is experimental evidence that it has the molecular function</span>: protein binding; protein serine/threonine kinase activity. There is experimental evidence that it is involved in the biological process</span>: peptidyl-serine phosphorylation; positive regulation of antibacterial peptide biosynthetic process; regulation of innate immune response; protein catabolic process; antibacterial humoral response. 16 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG4201-PA translation from_gene[CG4201 ird5 FBgn0024222] seq_release:3 mol_weight=86374 cds_boundaries:(3R:11,872,323..11,875,162[-]) aa_length:751 transcript_info:[CG4201-RA seq_release:3] gene_info:[gene symbol:ird5 FBgn0024222 gene_boundaries:(3R:1 [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9VEZ5) CG4201 protein [DrosMelano7227.FASTAC.txt]
  • CG4201-PA [Drosophila melanogaster]gi|24647336|ref|NP_524751.2| CG4201-PA [Drosophila melanogaster]gi|48428497|sp|Q9VEZ5|IKKB_DROME Inhibitor of nuclear factor kappa B kinase beta subunit (DmIKK-beta) (Immune response deficient protein 5) (IKK-like prot [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3R:complement(11872302..11872335,11872391..11872786,11872855..11873024,11873080..11874533,11874943..11875144); ID=FBpp0082690; name=ird5-PA; parent=FBgn0024222,FBtr0083236; dbxref=FlyBase:FBpp0082690,FlyBase_Annotation_IDs:CG4201-PA,GB_p [fly-100309-contam.fasta]
  • CG4201-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • immune response deficient 5 CG4201-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Inhibitor of nuclear factor kappa B kinase subunit beta (DmIKK-beta) (Immune response deficient protein 5) (IKK-like protein) (Lipopolysaccharide-activated kinase) (DLAK) (Cactus kinase IKK) [nr-271106-contam.fasta]
  • type=protein; loc=3R:complement(11872302..11872335,11872391..11872786,11872855..11873024,11873080..11874533,11874943..11875144); ID=FBpp0082690; name=ird5-PA; parent=FBgn0024222,FBtr0083236; dbxref=FlyBase:FBpp0082690,FlyBase_Annotation_IDs:CG4201-PA,GB_protein:AAF55267.2,REFSEQ:NP_524751,GB_protein:AAF55267; MD5=b12c97e776328c3fe3f9d4faad502622; length=751; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:complement(11872302..11872335,11872391..11872786,11872855..11873024,11873080..11874533,11874943..11875144); ID=FBpp0082690; name=ird5-PA; parent=FBgn0024222,FBtr0083236; dbxref=FlyBase:FBpp0082690,FlyBase_Annotation_IDs:CG4201-PA,GB_protein:AAF55267.2,REFSEQ:NP_524751,GB_protein:AAF55267; MD5=b12c97e776328c3fe3f9d4faad502622; length=751; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
    • Organism: Drosophila melanogaster
    Length: 751 amino acids

    Gene Ontology:
    Cellular Component: IkappaB kinase complex [ISS][NAS]
    cytoplasm [IDA]
    Biological Process: Toll signaling pathway [NAS][TAS]
    protein catabolic process [IDA]
    regulation of innate immune response [IMP]
    dorsal/ventral axis specification [NAS]
    antibacterial humoral response [IMP]
    antimicrobial humoral response [NAS]
    positive regulation of antibacterial peptide biosynthetic process [IMP][NAS]
    protein amino acid phosphorylation [NAS]
    peptidyl-serine phosphorylation [IDA]
    Molecular Function: ATP binding [IEA]
    protein binding [IPI]
    IkappaB kinase activity [ISS][NAS]
    protein kinase activity [NAS]
    protein serine/threonine kinase activity [IDA][ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MITVVFCFSD CHGGIQILGR MSSVNKIKLN ENNKMHSFGN WERCRNLGEG GFGLVIHWRN  60
   61 RTTGREIATK HIKEMGALSA DQQVKLSERW NKELNWSRQF KNFPHIVAGV DIEDPDFLEY 120
  121 LNGMFSAKLP VIVLEYCNGG DVRKRLQSPE NANGLTEFEV RQILGALRKA LHFLHSQCGI 180
  181 CHRDLKPDNI VIQRGVDGKK IYKLTDFGLA RGTPDQTMVQ SVVGTRHYYA PEVVENGFYN 240
  241 STVDLWSFGV IAYELVTGEL PFIPHQTLKN IILNLIKKPA KCIAITEDPE DNTRFVNQFE 300
  301 LPQTHHLSRP WAAQFTKWLA SPLNSNYKER GQLAANNVPV VFADLDKILN MNVLTIFAVN 360
  361 NCERLEYAVS AEMTMKDLIA LIVLDTGMDE KELYFVLPTS HPHKTITPKS TPLQLYVEEW 420
  421 SDTSKDSRKW TKRSNPPVML YIFQVKKECD YKIPEPILSI LSRKFIANKF KTKERWLQKR 480
  481 VVLDMLYVLT KEQARYEMLV SGINERALSL EDEMMENSFI DSIDKQRIII SFAYDQLTSL 540
  541 LKEAQAKIPS RQLISSAQWE KLNRNYNFII QSAKSIRSFL EACLREAKDM VKTTNQLRKE 600
  601 VCEKDLFDCA RFYKKYLCNG AIISPSELNN DAEEFAKSRF KLYNEGEARH LPKSIDHMHY 660
  661 LYFKTKESIP VLLQQFCDIK KEIFQINLQM LMSASSTPPP KLELSAAMDR LAISSGSPSS 720
  721 DPFDSLRTIN AIEEAERINN ILVNEMKIDH Y

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..385] PSI-BLAST 62.0 Pkb kinase
    2 View Details [386..751] PSI-BLAST 16.30103 Heavy meromyosin subfragment

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • protein kinase activity
    		•  5.17195961442593 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • binding
    		•  2.31930216202447 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • IkappaB kinase activity
    		•  2.01337046169267 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.3898059094397 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.38496328649031 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.27291233344322 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.913893847407112 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.821371946077904 bayes_pls_golite062009
  • receptor activity
    		•  0.775180603313375 bayes_pls_golite062009
  • transporter activity
    		•  0.595111702412257 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.58590430118616 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  0.461392047923247 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.41384976209545 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.35402045013148 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.302157011129993 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.300646491604114 bayes_pls_golite062009
  • signal transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • DNA binding
    		•  0.234035399242102 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.0922946791401962 bayes_pls_golite062009
  • transcription factor activity
    		•  0.071836086792026 bayes_pls_golite062009
  • transcription activator activity
    		•  0.0126825293063959 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0040394359628233 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle