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Protein Overview: mor-PA

General Information:
Name(s) found: mor-PA / FBpp0082692 [FlyBase]
Description(s) found:
Found 25 descriptions.
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  • The gene moira is referred to in FlyBase by the symbol Dmel\mor (CG18740, FBgn0002783). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:11793856..11798636. It has the cytological map location 89A8-89A11. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: positive regulation of transcription, DNA-dependent. 23 alleles are reported. The phenotypes of these alleles are annotated with: midgut constriction 2; ventral nerve cord commissure; eye; embryonic head; macrochaeta; embryonic peripheral nervous system; midgut constriction 1; wing. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1209 amino acids

    Gene Ontology:
    Cellular Component: brahma complex [IDA][NAS][TAS]
    chromatin remodeling complex [ISS]
    Biological Process: chromatin remodeling [NAS]
    oogenesis [NAS]
    positive regulation of transcription, DNA-dependent [IDA]
    Molecular Function: DNA binding [IEA]
    protein binding [IPI]
    transcription coactivator activity [IC]
    general RNA polymerase II transcription factor activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNTLGPKKDG SPNIDFFQSP ETLQGFESIR QWLQKNCKKY LAHSSEPITK ESLAQLLIHF  60
   61 LQYVEAKLGK NSADPPATRI PMRCFLDFKS GGGLCIIFST MFRFRAEQRG KKFDFSIGKN 120
  121 PTRKDPNIQL LIEIEQALVE ADLYRIPYIY IRPEIEKGFE GKLREILDNR RVEIVSDEED 180
  181 ATHIVYPVVD PHPDEYARPI FKRGGHVMLH WYYFPESYDS WAVNNFDLPD HIPENPESPA 240
  241 ERWRVSASWI VDLEQYNEWM AEEDYEVDEQ GKKKTHKQRM SIDDIMSFGD EKKKPAASSG 300
  301 GGKQKRRRSP SPASSASTSK PGKRKRSPAV VHKKSRNDDD DEDLTRDLDD PPAEPNVQEV 360
  361 HKANAALQST ASPAPGGKSR GDNDMMPIKG GTMTDLDDEM TGGSAAQAMS TGDGENSQTG 420
  421 KTSDNSNTQE FSSSAKEDME DNVTEQTHHI IVPSYSAWFD YNSIHVIEKR AMPEFFNSKN 480
  481 KSKTPEIYMA YRNFMIDTYR LNPTEYLTST ACRRNLAGDV CAIMRVHAFL EQWGLINYQI 540
  541 DADVRPTPMG PPPTSHFHIL SDTPSGLQSI NPQKTQQPSA AKTLLDLDKK PLGKDGGLEL 600
  601 GDKSGLTGIK TEALENGAAG GLSSGVSQFG LKLDQYAKKP AAMRNRTAAS MAREWTDQET 660
  661 LLLLEGLEMH KDDWNKVCEH VGSRTQDECI LHFLRLPIED PYLEDDGGFL GPLACQPIPF 720
  721 SKSGNPIMST VAFLASVVDP RVAAAAAKAA MEEFAAIKDE VPATIMDNHL KNVEKASAGG 780
  781 KFNPNFGLAN SGIAGTGNDK DDEEGKEGGA SASAGGSDEE MKDLSKKDDD AKSKDNTKSD 840
  841 KTNTNTDSSS TSSSATGNTN NTDKKPKESS GSSPSGDKSA IKSDKSNKSS PTETAAAASG 900
  901 GEVDIKTEDS SGDGETKDGT EAKEGTGTGT GPLAVPKEGT FSENNMQTAA AAALASAAVK 960
  961 AKHLAALEER KIKSLVALLV ETQMKKLEIK LRHFEELEAT MEREREGLEY QRQQLITERQ1020
 1021 QFHLEQLKAA EFRARQQAHH RLQQELQGQA AAGSMILPQQ QQLPQAQQPQ QQQQTLPPHP1080
 1081 HLAQQQQLPP HPHQLPPQSQ PLAGPTAQHQ PLPPHVVSSP NGAPFAAPPI SLTGGLPPGA1140
 1141 PTAIVTNPSD QTGPVAAGAA QSQAPTPMDT TPPSSGPVSD ANAPPGSAMP PGGIPPANTA1200
 1201 PIAGVAPSS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..236] MSA 2.034931 View MSA. No confident structure predictions are available.
    2 View Details [237..337] PSI-BLAST 11.522879 Solution structure of the SANT domain of human KIAA1915 protein
    3 View Details [338..409] deduced N/A No confident structure predictions are available.
    4 View Details [410..542] PSI-BLAST 39.0 Structure and function of the SWIRM domain, a conserved protein module found in chromatin regulatory complexes
    5 View Details [543..649] deduced N/A No confident structure predictions are available.
    6 View Details [650..763] PSI-BLAST 5.522879 No description for 2elkA was found.
    7 View Details [764..829] deduced N/A No confident structure predictions are available.
    8 View Details [830..1209] PSI-BLAST 11.522879 No description for 1y0fB was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  5.13863038737912 bayes_pls_golite062009
  • DNA binding
    		•  4.66369707598026 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.51452285155271 bayes_pls_golite062009
  • transcription factor activity
    		•  4.06706589695599 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  3.5139760613123 bayes_pls_golite062009
  • transcription activator activity
    		•  3.10621734076555 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.26183812259792 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.91962622287073 bayes_pls_golite062009
  • protein binding
    		•  1.88087411289001 bayes_pls_golite062009
  • transcription factor binding
    		•  1.40653841901929 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  1.40149699217445 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  1.40149699217445 bayes_pls_golite062009
  • protein deacetylase activity
    		•  1.23680480131205 bayes_pls_golite062009
  • histone deacetylase activity
    		•  1.18932416576802 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.14886080629275 bayes_pls_golite062009
  • chromatin binding
    		•  1.04132983826241 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.84983974758882 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.810065362108106 bayes_pls_golite062009
  • histone binding
    		•  0.557787598121402 bayes_pls_golite062009
  • deacetylase activity
    		•  0.530687254192222 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.2679415219517 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.25931464844298 bayes_pls_golite062009
  • N-acyltransferase activity
    		•  0.212884313176726 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  0.13444271681002 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.85

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle