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View Structure Prediction Details

Protein: mor-PA
Organism: Drosophila melanogaster
Length: 1209 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for mor-PA.

Description E-value Query
Range
Subject
Range
gi|114586606 - gi|114586606|ref|XP_001154323.1| PREDICTED: SWI/SNF-related matrix-associated actin-dependent regula...
1049.0 [0..6] [1079..32]

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Predicted Domain #1
Region A:
Residues: [1-236]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNTLGPKKDG SPNIDFFQSP ETLQGFESIR QWLQKNCKKY LAHSSEPITK ESLAQLLIHF  60
   61 LQYVEAKLGK NSADPPATRI PMRCFLDFKS GGGLCIIFST MFRFRAEQRG KKFDFSIGKN 120
  121 PTRKDPNIQL LIEIEQALVE ADLYRIPYIY IRPEIEKGFE GKLREILDNR RVEIVSDEED 180
  181 ATHIVYPVVD PHPDEYARPI FKRGGHVMLH WYYFPESYDS WAVNNFDLPD HIPENP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [237-337]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ESPAERWRVS ASWIVDLEQY NEWMAEEDYE VDEQGKKKTH KQRMSIDDIM SFGDEKKKPA  60
   61 ASSGGGKQKR RRSPSPASSA STSKPGKRKR SPAVVHKKSR N

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.522879
Match: 2cu7A
Description: Solution structure of the SANT domain of human KIAA1915 protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
sequence-specific DNA binding 3.5139760613123 bayes_pls_golite062009
transcription activator activity 3.10621734076555 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.26183812259792 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
protein binding 1.88087411289001 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
histone acetyltransferase activity 1.40149699217445 bayes_pls_golite062009
lysine N-acetyltransferase activity 1.40149699217445 bayes_pls_golite062009
protein deacetylase activity 1.23680480131205 bayes_pls_golite062009
histone deacetylase activity 1.18932416576802 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.14886080629275 bayes_pls_golite062009
chromatin binding 1.04132983826241 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.810065362108106 bayes_pls_golite062009
histone binding 0.557787598121402 bayes_pls_golite062009
deacetylase activity 0.530687254192222 bayes_pls_golite062009
transcription coactivator activity 0.2679415219517 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009
N-acyltransferase activity 0.212884313176726 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 0.13444271681002 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [338-409]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DDDDEDLTRD LDDPPAEPNV QEVHKANAAL QSTASPAPGG KSRGDNDMMP IKGGTMTDLD  60
   61 DEMTGGSAAQ AM

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [410-542]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STGDGENSQT GKTSDNSNTQ EFSSSAKEDM EDNVTEQTHH IIVPSYSAWF DYNSIHVIEK  60
   61 RAMPEFFNSK NKSKTPEIYM AYRNFMIDTY RLNPTEYLTS TACRRNLAGD VCAIMRVHAF 120
  121 LEQWGLINYQ IDA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 39.0
Match: 2fq3A
Description: Structure and function of the SWIRM domain, a conserved protein module found in chromatin regulatory complexes
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [543-649]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DVRPTPMGPP PTSHFHILSD TPSGLQSINP QKTQQPSAAK TLLDLDKKPL GKDGGLELGD  60
   61 KSGLTGIKTE ALENGAAGGL SSGVSQFGLK LDQYAKKPAA MRNRTAA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [650-763]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SMAREWTDQE TLLLLEGLEM HKDDWNKVCE HVGSRTQDEC ILHFLRLPIE DPYLEDDGGF  60
   61 LGPLACQPIP FSKSGNPIMS TVAFLASVVD PRVAAAAAKA AMEEFAAIKD EVPA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.522879
Match: 2elkA
Description: No description for 2elkA was found.

Predicted Domain #7
Region A:
Residues: [764-829]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TIMDNHLKNV EKASAGGKFN PNFGLANSGI AGTGNDKDDE EGKEGGASAS AGGSDEEMKD  60
   61 LSKKDD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [830-1209]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DAKSKDNTKS DKTNTNTDSS STSSSATGNT NNTDKKPKES SGSSPSGDKS AIKSDKSNKS  60
   61 SPTETAAAAS GGEVDIKTED SSGDGETKDG TEAKEGTGTG TGPLAVPKEG TFSENNMQTA 120
  121 AAAALASAAV KAKHLAALEE RKIKSLVALL VETQMKKLEI KLRHFEELEA TMEREREGLE 180
  181 YQRQQLITER QQFHLEQLKA AEFRARQQAH HRLQQELQGQ AAAGSMILPQ QQQLPQAQQP 240
  241 QQQQQTLPPH PHLAQQQQLP PHPHQLPPQS QPLAGPTAQH QPLPPHVVSS PNGAPFAAPP 300
  301 ISLTGGLPPG APTAIVTNPS DQTGPVAAGA AQSQAPTPMD TTPPSSGPVS DANAPPGSAM 360
  361 PPGGIPPANT APIAGVAPSS 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.522879
Match: 1y0fB
Description: No description for 1y0fB was found.

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Created and Maintained by: Michael Riffle