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Protein Overview: CG31183-PA, FBpp...

General Information:
Name(s) found: FBpp0311979 [FlyBase]
CG31183-PA / FBpp0082641 [FlyBase]
Description(s) found:
Found 23 descriptions.
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  • type=protein; loc=3R:complement(11684053..11685661,11685720..11685903,11687493..11687657,11687811..11688539,11688706..11689132,11690507..11690651,11692175..11692289,11694895..11695774); ID=FBpp0311979; name=CG31183-PB; parent=FBgn0051183,FBtr0346151; dbxref=FlyBase:FBpp0311979,FlyBase_Annotation_IDs:CG31183-PB; MD5=920a5b1f77bf085ff187b2ca36d8a65e; length=1417; release=r5.56; species=Dmel; [FlyBase]
  • This gene is referred to in FlyBase by the symbol Dmel\CG31183 (CG31183, FBgn0051183). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:11683801..11695774. It has the cytological map location 89A6. Based on sequence similarity, it is predicted to have molecular function</span>: natriuretic peptide receptor activity; guanylate cyclase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: cyclic nucleotide biosynthetic process; protein amino acid phosphorylation; intracellular signaling cascade. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1417 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEA]
    Biological Process: intracellular signaling pathway [IEA]
    protein amino acid phosphorylation [IEA]
    cyclic nucleotide biosynthetic process [IEA]
    Molecular Function: ATP binding [IEA]
    protein tyrosine kinase activity [IEA]
    peptide receptor activity, G-protein coupled [IEA]
    guanylate cyclase activity [ISS][NAS]
    natriuretic peptide receptor activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPQAGQGLSL LLILCLLQAH LFPSAAWFYD AESVGGVASI GVGSDEHSFK TPETKNSHKS  60
   61 QSTELVQHFP SLPMPDHRRL GARRQLVFVA LLPSVESDNK NDCIMPKVLP VLELAIRHVQ 120
  121 RMGFVGGSHF DIQLISRDTF CSSKYGPIGF FEIYTQWPEV NAVFGLPCEY VLAPISRYAD 180
  181 VWQVPVLTTG GNAKEFNKKS ESYSTLTRLK GAQVNNLGNV VRAILNSFNW TRTALIYQNE 240
  241 NAKVKGNSVC FLCLAAIHDT IEEHSVYQLG FDTSTWTKAD ITRMLKNVAM QSRIVIMCAD 300
  301 PQSIRQIMLT AEELNMIDSG EYVFINIELF SRVQYLTSQP WYDKNDTDLN NERAQKAYTA 360
  361 MLTVTPKQPN DNEYTRVSNE IKAIAAEKYN YTFSDNEPIS AFVTSFFDGV LLYANALNES 420
  421 IREDPTMLTR PINGTDMVRR MWNRSFTGIT GNVTIDANGD RLSAYSLLDM NPTTGRFEIV 480
  481 AHFLHNRLEF EANKEIHWAG DREEAPPDRP ICGYDGALCP DNSLPGYAIL SIVLGTMVVV 540
  541 MAVCFFFGYR HYIAEAEINS MSWKVSLEDV MFRDAAERGL RGSFHSLVKQ SSQLTLMSED 600
  601 MVSINGDRQI FIPVGMFRKS KVAIKPVEVD NVQGLLTRSL MLELKRMKDL QHDHLVKFYG 660
  661 ACLDQRRSFL LTEYCPKGSL QDILENEQFQ LDWMFRLSLM HDIVRGMQFL HSSDIRSHGN 720
  721 LKSSNCVVDS RFVLKITDFG LHTLRRTRFD LESDGGNCNS HAYWSKLLWT APELLRVEHN 780
  781 RPPEGTQKGD VYAFGIIVHE ITTRQGPFYL GRCAYEKSPQ EIIELVKGYN PHRMQKPFRP 840
  841 ELEPNGDTKA DINGIIRRCW AEDPAERPDF NTLKSMIRRF NKDNETGNIV DNLLKRMELY 900
  901 ANNLEELVEE RTQDYHEEKK KCEKLLYQLL PQSVAAQLIS GQPVVAETFD QVTIYFSDIV 960
  961 GFTAISAEST PMQVVQFLND LYTCFDSIVE NFDVYKVETI GDAYMVVSGL PIRNGNQHAR1020
 1021 EIARLALALL EAVHNFRIHH RPEDRLKLRI GLHTGACVAG VVGLKMPRYC LFGDTVNTAS1080
 1081 RMESNGEALK IHISETTKEA LDEFGTFVTT RRGFVPMKGK GEMLTYWLEG EVPRPNSLIS1140
 1141 PSKLMLTRRS SLKQPQRSQS HNLHKQYSEL VVASPPPQLP PPAIALPPPP SPSKDSPNLR1200
 1201 VKRKISSSSP KLNGGGFDYH KTENHYLDTA AAAQRNCDIY SSRSLRDMEE TSDSWELAHF1260
 1261 RLPLSGALKS HHHLNNNSHG YVHSNSSSNL SGILQPPPLG VQRTRLKPSP TISTLLTSAR1320
 1321 SEANASPGPE TGSMGSGQLR IKFAEGDETP LLPTPPPLAA PPPIPQMVAA SPQRSGSGQN1380
 1381 IPADSSHYGF LVKSYKQQCP PVAGSAVTQP LLAKINS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..77] deduced N/A No confident structure predictions are available.
    2 View Details [78..537] PSI-BLAST 56.30103 Hormone binding domain of the atrial natriuretic peptide receptor
    3 View Details [538..867] PSI-BLAST 42.30103 No description for 2helA was found.
    4 View Details [868..992] FFAS03 2.74 Soluble adenylyl cyclase CyaC from S. platensis in complex with Rp- ATPalphaS
    5 View Details [993..1148] PSI-BLAST 44.045757 Crystal structure of a mutant form of the mycobacterial adenylyl cyclase Rv1625c
    6 View Details [1149..1282] deduced N/A No confident structure predictions are available.
    7 View Details [1283..1417] MSA 5.082991 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • G-protein coupled receptor activity
    		•  5.7202621143437 bayes_pls_golite062009
  • adenylate cyclase inhibiting metabotropic glutamate receptor activity
    		•  4.93954353870922 bayes_pls_golite062009
  • transcription regulator activity
    		•  4.34309008728616 bayes_pls_golite062009
  • receptor activity
    		•  4.1442086696021 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  4.0843113712194 bayes_pls_golite062009
  • glutamate receptor activity
    		•  3.96829643900059 bayes_pls_golite062009
  • group III metabotropic glutamate receptor activity
    		•  3.96653802746406 bayes_pls_golite062009
  • DNA binding
    		•  3.61776323775806 bayes_pls_golite062009
  • transcription factor activity
    		•  3.44509182129646 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.36600402123347 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.17421789884883 bayes_pls_golite062009
  • signal transducer activity
    		•  3.17421789884883 bayes_pls_golite062009
  • binding
    		•  2.92042936761166 bayes_pls_golite062009
  • peptide receptor activity
    		•  2.69138343857418 bayes_pls_golite062009
  • guanylate cyclase activity
    		•  2.42987465654642 bayes_pls_golite062009
  • group II metabotropic glutamate receptor activity
    		•  2.02460911416872 bayes_pls_golite062009
  • cyclase activity
    		•  1.95391742402237 bayes_pls_golite062009
  • transporter activity
    		•  1.94865852692163 bayes_pls_golite062009
  • PLC activating metabotropic glutamate receptor activity
    		•  1.93160762343283 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.83955873328417 bayes_pls_golite062009
  • amine binding
    		•  1.6373817551539 bayes_pls_golite062009
  • peptide binding
    		•  1.60700803165111 bayes_pls_golite062009
  • phosphorus-oxygen lyase activity
    		•  1.51094915686986 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.45087364463083 bayes_pls_golite062009
  • natriuretic peptide receptor activity
    		•  1.3877109000054 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.34941602745967 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  1.30369066890706 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  1.29881269915303 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  1.29466697797865 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  1.27441358428626 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  1.27125980233959 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  1.27088454405241 bayes_pls_golite062009
  • carbohydrate binding
    		•  1.24878820273096 bayes_pls_golite062009
  • protein binding
    		•  1.23723635587647 bayes_pls_golite062009
  • transcription activator activity
    		•  1.23600343828473 bayes_pls_golite062009
  • taste receptor activity
    		•  1.21173489127635 bayes_pls_golite062009
  • sugar binding
    		•  0.95501261360996 bayes_pls_golite062009
  • peptide receptor activity, G-protein coupled
    		•  0.830628582065238 bayes_pls_golite062009
  • peptide hormone binding
    		•  0.744531200386629 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  0.688251096406204 bayes_pls_golite062009
  • amino acid binding
    		•  0.64866609432579 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.56157419182036 bayes_pls_golite062009
  • ATPase activity
    		•  0.486508168109568 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.481441942208549 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.419287381048087 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.403674689236963 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.400732473817975 bayes_pls_golite062009
  • glutamate binding
    		•  0.345623202096461 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.265482111518448 bayes_pls_golite062009
  • gated channel activity
    		•  0.197987086788784 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.0604479939440918 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
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