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Protein Overview: FBpp0306662, rec-PA

General Information:
Name(s) found: FBpp0306662 [FlyBase]
rec-PA / FBpp0082647 [FlyBase]
Description(s) found:
Found 26 descriptions.
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  • type=protein; loc=3R:complement(11650199..11650592,11656076..11658339); ID=FBpp0306662; name=rec-PB; parent=FBgn0003227,FBtr0334595; dbxref=FlyBase:FBpp0306662,FlyBase_Annotation_IDs:CG31293-PB,REFSEQ:NP_001262615,GB_protein:AGB95995; MD5=b93004d277d25db2db0a3e447d6de95e; length=885; release=r5.56; species=Dmel; [FlyBase]
  • The gene recombination-defective is referred to in FlyBase by the symbol Dmel\rec (CG31293, FBgn0003227). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:11648709..11658354. It has the cytological map location 89A5. Based on sequence similarity, it is predicted to have molecular function</span>: ATP-dependent DNA helicase activity. There is experimental evidence that it is involved in the biological process</span>: reciprocal meiotic recombination. 9 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 885 amino acids

    Gene Ontology:
    Cellular Component: replication fork [ISS]
    pre-replicative complex [ISS]
    Biological Process: reciprocal meiotic recombination [IMP][NAS]
    DNA replication [IEA][ISS]
    Molecular Function: ATP binding [IEA]
    DNA binding [IEA]
    ATP-dependent DNA helicase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNPTLSRGGA PSRFVRGRGR GGGAYRPYFY FRRNGRVIPA GGNRQPNQGE PGAPDAPSVP  60
   61 PATRQPRGWS RTAGKRGRNA HLDCSFLRPE NYAAPEDGLQ VQSIAVDNPR AYSGWRLYFL 120
  121 REKYEEGNEL ATRIMAVEAY YQRNPHTFDF VMIRDRGFFP LCAAGIKSDA QLKEVWPSLS 180
  181 EDIREHPLRT LGTLSLAMHT VVVNHQLDCN DSTTAMVSTP EQYVLPTPRV RKIYARPDDF 240
  241 VPVESIEGIS HSRVDTLFSI RGFVSNVGEP SYSLTWQAFR CSRCQMEIAM RQRGTFQPRP 300
  301 YQCKRSECVA RDEFVPLRSS PYTRLSIRQI IRVEESSLNL VHDFETSMPA EMDVELRHDL 360
  361 VDAVRVGQEV VVTGILKLQE LGDDTTTGDT SNQMQPYLKA VSIRDASSIK REFSERDLEA 420
  421 IVMINAEPNS FKLLVQSIAP EVYGHELPKA ACLLSLLGGK GAETEAINVL LVGDPGIGKT 480
  481 KILQSCAQIA ERGAHVSGKR GAQSAQQLGV TFAGRNKRVL QAGSLMMASG GGHCTLDDVD 540
  541 KLASKQAVLL QCLQSEEVNL PLAGAFASFP AQPSVIACAN PQRGQYDEGR YLLQNINISP 600
  601 SLLREFHLVY ILLDKPSERD MSLTAHVRAL HAGARKRARI AARYALKPKM SDSMCEVSLN 660
  661 VPAAGKDDDT IKTEDDNDSI MQQDYDLDKR LEVLPEEGDL DLLPPILIKK FLSYARQELN 720
  721 PVLNEDASNA VLRYFLELKG SCNLDEDVSS QIGAGQLLAI IHLSQARARL DLSHVVSPQH 780
  781 VRDVIALLTE SITQTSLKEG SSRQGTRGGG GAGGGAGKSA QLRNFLELTK RRSAALGRRI 840
  841 FEFDELKEIG TRAGILTGFS QLVEMANLGG YLLMKGANMY EVVPD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..110] MSA 4.117997 View MSA. No confident structure predictions are available.
    2 View Details [111..269] PSI-BLAST 40.39794 DNA replication initiator (cdc21/cdc54) N-terminal domain
    3 View Details [270..703] PSI-BLAST 14.0 N-terminal, ClpS-binding domain of ClpA, an Hsp100 chaperone; ClpA, an Hsp100 chaperone, AAA+ modules
    4 View Details [704..885] PSI-BLAST 57.30103 EDTA treated

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • DNA clamp loader activity
    		•  3.94645534451735 bayes_pls_golite062009
  • protein-DNA loading ATPase activity
    		•  3.91355858456767 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  2.72462789867829 bayes_pls_golite062009
  • DNA helicase activity
    		•  2.2817164193758 bayes_pls_golite062009
  • binding
    		•  2.05253348982328 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.04806869603661 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  1.88455339138556 bayes_pls_golite062009
  • helicase activity
    		•  1.70242731830224 bayes_pls_golite062009
  • microtubule motor activity
    		•  1.6537049553461 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.49633029954726 bayes_pls_golite062009
  • motor activity
    		•  1.32129340699286 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • DNA binding
    		•  0.967303417236485 bayes_pls_golite062009
  • DNA polymerase activity
    		•  0.795745617990735 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.782430219754236 bayes_pls_golite062009
  • DNA-directed DNA polymerase activity
    		•  0.771854032852428 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.748437190903548 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.6071273686445 bayes_pls_golite062009
  • protein binding
    		•  0.508848095576342 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  0.367559137329714 bayes_pls_golite062009
  • nucleotide binding
    		•  0.114848452385726 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.10713474095071 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.0916519414118148 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.0915913646217636 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.089234257580272 bayes_pls_golite062009
  • four-way junction helicase activity
    		•  0.0763022821830703 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0530667986761242 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.028470639373934 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.0265151533232588 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle