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Protein Overview: Caf1-PA

General Information:
Name(s) found: Caf1-PA / FBpp0082511 [FlyBase]
Description(s) found:
Found 51 descriptions.
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  • The gene Chromatin assembly factor 1 subunit is referred to in FlyBase by the symbol Dmel\Caf1 (CG4236, FBgn0015610). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:11051289..11053286. It has the cytological map location 88E3. There is experimental evidence that it has the molecular function</span>: histone acetyltransferase binding; SUMO binding; histone deacetylase binding. There is experimental evidence for 13 unique biological process</span> terms, many of which group under: chromatin organization; anatomical structure development; cellular macromolecular complex subunit organization; biopolymer modification; negative regulation of cellular biosynthetic process; regulation of biological process; negative regulation of nitrogen compound metabolic process; organelle organization; cellular macromolecule metabolic process; protein modification process; neuron differentiation. 4 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 430 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA][NAS]
    polytene chromosome [IDA]
    chromatin assembly complex [NAS]
    transcription factor complex [IPI]
    [NOT]ACF complex [IDA]
    ESC/E(Z) complex [IDA]
    chromatin remodeling complex [NAS]
    Myb complex [IDA]
    NURF complex [IPI][NAS][TAS]
    Biological Process: DNA repair [TAS]
    transcription [IDA]
    cytokinesis [IMP]
    chromatin silencing [IPI]
    neuron development [IMP]
    nucleosome assembly [IDA][NAS]
    regulation of mitotic cell cycle [IMP]
    nucleosome mobilization [IDA]
    DNA replication-dependent nucleosome assembly [NAS]
    dendrite morphogenesis [IMP]
    negative regulation of transcription from RNA polymerase II promoter [IMP]
    muscle organ development [IMP]
    eggshell chorion gene amplification [IC]
    histone methylation [IDA]
    nucleosome positioning [IDA]
    histone acetylation [IDA][ISS]
    Molecular Function: SUMO binding [IPI]
    histone acetyltransferase binding [IPI][ISS]
    histone deacetylase binding [IPI][ISS]
    histone binding [NAS][TAS]
    histone methyltransferase activity (H3-K9 specific) [IC]
    chromatin binding [NAS]
    histone methyltransferase activity (H3-K27 specific) [IC]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVDRSDNAAE SFDDAVEERV INEEYKIWKK NTPFLYDLVM THALEWPSLT AQWLPDVTKQ  60
   61 DGKDYSVHRL ILGTHTSDEQ NHLLIASVQL PSEDAQFDGS HYDNEKGEFG GFGSVCGKIE 120
  121 IEIKINHEGE VNRARYMPQN ACVIATKTPS SDVLVFDYTK HPSKPEPSGE CQPDLRLRGH 180
  181 QKEGYGLSWN PNLNGYLLSA SDDHTICLWD INATPKEHRV IDAKNIFTGH TAVVEDVAWH 240
  241 LLHESLFGSV ADDQKLMIWD TRNNNTSKPS HTVDAHTAEV NCLSFNPYSE FILATGSADK 300
  301 TVALWDLRNL KLKLHSFESH KDEIFQVQWS PHNETILASS GTDRRLHVWD LSKIGEEQST 360
  361 EDAEDGPPEL LFIHGGHTAK ISDFSWNPNE PWIICSVSED NIMQVWQMAE NVYNDEEPEI 420
  421 PASELETNTA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..353] PSI-BLAST 52.69897 Tup1, C-terminal domain
    2 View Details [354..430] PSI-BLAST 57.69897 F-box/WD-repeat protein 1 (beta-TRCP1)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
    		• 6.67009948605948 bayes_pls_golite062009
  • snoRNA binding
    		•  4.78410616474982 bayes_pls_golite062009
  • histone methyltransferase activity (H3-K4 specific)
    		•  4.71992275913384 bayes_pls_golite062009
  • acetyltransferase activity
    		•  3.85374902981345 bayes_pls_golite062009
  • RNA binding
    		•  3.77273677738815 bayes_pls_golite062009
  • acyltransferase activity
    		•  3.35098520158193 bayes_pls_golite062009
  • transferase activity, transferring acyl groups other than amino-acyl groups
    		•  3.31615347567536 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  3.14917998298348 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  3.1056443224755 bayes_pls_golite062009
  • actin binding
    		•  2.82238441497141 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  2.79445416141967 bayes_pls_golite062009
  • binding
    		•  2.42570478946173 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.3610959773142 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.30918780727915 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.29049708962212 bayes_pls_golite062009
  • protein binding
    		•  2.26925404328312 bayes_pls_golite062009
  • S-adenosylmethionine-dependent methyltransferase activity
    		•  2.18628561734369 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  1.85632145559025 bayes_pls_golite062009
  • dynein binding
    		•  1.75753266122574 bayes_pls_golite062009
  • peroxisome targeting sequence binding
    		•  1.73465159850484 bayes_pls_golite062009
  • tubulin binding
    		•  1.71990413056683 bayes_pls_golite062009
  • DNA binding
    		•  1.71685536470455 bayes_pls_golite062009
  • microtubule binding
    		•  1.58000769768764 bayes_pls_golite062009
  • structural molecule activity
    		•  1.47097979074281 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.41752877005447 bayes_pls_golite062009
  • protein methyltransferase activity
    		•  1.35170368882651 bayes_pls_golite062009
  • histone-lysine N-methyltransferase activity
    		•  1.15313682561559 bayes_pls_golite062009
  • protein-lysine N-methyltransferase activity
    		•  1.15313682561559 bayes_pls_golite062009
  • lysine N-methyltransferase activity
    		•  1.15313682561559 bayes_pls_golite062009
  • actin filament binding
    		•  1.10832047454002 bayes_pls_golite062009
  • transcription factor activity
    		•  1.08768505897883 bayes_pls_golite062009
  • mRNA binding
    		•  1.05053985350578 bayes_pls_golite062009
  • transcription initiation factor activity
    		•  1.01962930136588 bayes_pls_golite062009
  • transporter activity
    		•  0.692270256454453 bayes_pls_golite062009
  • histone binding
    		•  0.685319917508843 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.676924760416604 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.625780732991652 bayes_pls_golite062009
  • transcription factor binding
    		•  0.489473003915035 bayes_pls_golite062009
  • DNA polymerase activity
    		•  0.428715007921149 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.426429095658617 bayes_pls_golite062009
  • kinase activity
    		•  0.387572734234845 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.30761651528651 bayes_pls_golite062009
  • protein kinase activity
    		•  0.229242350006544 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.226335610368636 bayes_pls_golite062009
  • receptor binding
    		•  0.221365584462661 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.220747580531792 bayes_pls_golite062009
  • myosin binding
    		•  0.16849147094895 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.161639372576406 bayes_pls_golite062009
  • chromatin binding
    		•  0.151977098745772 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.121183207943714 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.118975415284669 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.00585398682921312 bayes_pls_golite062009
  • N-methyltransferase activity
    		•  0.00335766408304172 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle