YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure. Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins. A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4. Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. Any constituent part of the nucleoplasm, that part of the nuclear content other than the chromosomes or the nucleolus. A protein complex that possesses methyltransferase activity.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: ESC/E(Z) complex
Acc: GO:0035098
Aspect: Cellular Component
Desc: A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4.
Synonyms:
  • PRC2 complex
  • Extra Sex Combs/Enhancer of Zeste complex
Proteins in PDR annotated with:
   This term: 17 [Search]
   Term or descendants: 17 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0035098 - ESC/E(Z) complex (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle