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Protein Overview: spn-B-PA

General Information:
Name(s) found: spn-B-PA / FBpp0082392 [FlyBase]
Description(s) found:
Found 27 descriptions.
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  • The gene spindle B is referred to in FlyBase by the symbol Dmel\spn-B (CG3325, FBgn0003480). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:10153786..10155331. It has the cytological map location 88B4. Based on sequence similarity, it is predicted to have molecular function</span>: recombinase activity. There is experimental evidence that it is involved in the biological process</span>: germarium-derived oocyte fate determination; polarity specification of dorsal/ventral axis; intracellular mRNA localization; oogenesis; polarity specification of anterior/posterior axis; karyosome formation. 13 alleles are reported. The phenotypes of these alleles are annotated with: germline cyst; egg; oocyte; presumptive oocyte; karyosome; oocyte nucleus; dorsal appendage; nurse cell; synaptonemal complex. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 341 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: DNA repair [ISS][NAS]
    intracellular mRNA localization [IMP][TAS]
    reciprocal meiotic recombination [TAS]
    germarium-derived oocyte fate determination [IGI]
    chromosome condensation [TAS]
    DNA recombination [ISS]
    polarity specification of dorsal/ventral axis [IMP]
    oocyte differentiation [NAS]
    DNA metabolic process [IEA]
    meiosis [TAS]
    double-strand break repair [TAS]
    polarity specification of anterior/posterior axis [IMP]
    regulation of translation [TAS]
    oogenesis [IGI][TAS]
    karyosome formation [IMP]
    Molecular Function: DNA binding [IEA]
    ATP binding [IEA]
    DNA-dependent ATPase activity [IEA]
    recombinase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTNFLDQLPK HIREIAEQVN VLAPEEVLTT PKVRFLDTRQ QSLHTIVRKC TPDDVRVLKD  60
   61 AAAKWLAEMP QSADSLFKPL VNVRWSRVSF GCSALDRCTG GGVVTRGITE LCGAAGVGKT 120
  121 QLLLQLSLCV QLPRELGGLG KGVAYICTES SFPARRLLQM SKACEKRHPE MELNFLGNIF 180
  181 VENHIEAEPL LACVINRIPR LMQQHGIGLI IIDSVAAIFR LYNDYLERAR HMRRLADALL 240
  241 SYADKYNCAV VCVNQVATRD GQDEIPCLGL QWAHLGRTRL RVSRVPKQHR MGDQLITVRK 300
  301 LEILYSPETP NDFAEFLITA EGVVNVPEPS VPSPPAKMRR L

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..341] PSI-BLAST 65.69897 Crystal structure of the human Dmc1 protein

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • motor activity
    		•  2.79327761685782 bayes_pls_golite062009
  • microtubule motor activity
    		•  2.74365461017633 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  2.72462789867829 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.36915495988847 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.29436982996465 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.27303683020046 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.27190707957159 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.11222585187695 bayes_pls_golite062009
  • DNA helicase activity
    		•  2.10134737488849 bayes_pls_golite062009
  • DNA binding
    		•  1.7904783386531 bayes_pls_golite062009
  • ATPase activity
    		•  1.76238574289941 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  1.71882026185027 bayes_pls_golite062009
  • helicase activity
    		•  1.70242731830224 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.68903321260301 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  1.57826779898847 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  1.47858140861683 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.40488517180956 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.2539059700735 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  1.117585097627 bayes_pls_golite062009
  • protein-DNA loading ATPase activity
    		•  1.08464552192299 bayes_pls_golite062009
  • DNA-directed DNA polymerase activity
    		•  1.02269224635866 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • DNA polymerase activity
    		•  0.987648886158896 bayes_pls_golite062009
  • hydrolase activity
    		•  0.98565595572967 bayes_pls_golite062009
  • tubulin binding
    		•  0.979946830272106 bayes_pls_golite062009
  • DNA clamp loader activity
    		•  0.91282941965371 bayes_pls_golite062009
  • microtubule binding
    		•  0.907162506177187 bayes_pls_golite062009
  • actin binding
    		•  0.883285269827407 bayes_pls_golite062009
  • structural molecule activity
    		•  0.86514677273731 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.725611289205392 bayes_pls_golite062009
  • nucleotide binding
    		•  0.717697610309727 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.713814218071151 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.713752628021599 bayes_pls_golite062009
  • transcription factor activity
    		•  0.603758349693077 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.568457189190858 bayes_pls_golite062009
  • recombinase activity
    		•  0.45851158693664 bayes_pls_golite062009
  • GTPase activity
    		•  0.437665353870877 bayes_pls_golite062009
  • RNA helicase activity
    		•  0.34746349346164 bayes_pls_golite062009
  • centromeric DNA binding
    		•  0.322818640526369 bayes_pls_golite062009
  • mismatched DNA binding
    		•  0.31144582840038 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  0.30832907234141 bayes_pls_golite062009
  • guanyl nucleotide binding
    		•  0.296406132096546 bayes_pls_golite062009
  • GTP binding
    		•  0.295705904888768 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  0.29532978396745 bayes_pls_golite062009
  • translation regulator activity
    		•  0.29096092258568 bayes_pls_golite062009
  • guanyl ribonucleotide binding
    		•  0.29028316917561 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.274994961137851 bayes_pls_golite062009
  • ATP binding
    		•  0.19169045543599 bayes_pls_golite062009
  • protein binding
    		•  0.170837278876362 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.165732470448462 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.162060759063149 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.144154288308693 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.114463153989353 bayes_pls_golite062009
  • microfilament motor activity
    		•  0.10236059675512 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.66

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle