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Protein Overview: CG10535-PA

General Information:
Name(s) found: CG10535-PA / FBpp0081896 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • This gene is referred to in FlyBase by the symbol Dmel\CG10535 (CG10535, FBgn0037926). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:7476710..7481062. It has the cytological map location 86E13. Based on sequence similarity, it is predicted to have molecular function</span>: phosphorylase kinase regulator activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: regulation of transcription from RNA polymerase II promoter. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1252 amino acids

    Gene Ontology:
    Cellular Component: transcription elongation factor complex [ISS]
    cytoplasm [ISS]
    Biological Process: signal transduction [NAS]
    defense response [NAS]
    RNA interference [IMP]
    regulation of transcription from RNA polymerase II promoter [ISS]
    Molecular Function: phosphorylase kinase regulator activity [ISS]
    RNA-directed RNA polymerase activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRNLKLRYCK ELNAVAHPQH LLLQPELNGG ASDIYFVVAD NKIYAVQESG DVRLKVIADL  60
   61 PDIVGVEFLQ LDNAICVASG AGEVILVDPQ TGATSEGTFC DVGIESMAWS PNQEVVAFVT 120
  121 RTHNVVLMTS TFDVIAEQPL DAELDPDQQF VNVGWGKKET QFHGSEGKQA AKQKESDSTF 180
  181 IRDEQELNQD VSISWRGDGE FFVVSYVAAQ LGRTFKVYDS EGKLNHTAEK SANLKDSVVW 240
  241 RPTGNWIAVP QQFPNKSTIA LFEKNGLRHR ELVLPFDLQE EPVVQLRWSE DSDILAIRTC 300
  301 AKEEQRVYLY TIGNYHWYLK QVLIFEQADP LALLHWDTRC GAEHTLHVLK ESGKHLVYRW 360
  361 AFAVDRNNSI VGVIDGKRLL LTDFDEAIVP PPMSKIVLKF ETYINAFISH GTSLWVYTCD 420
  421 RKIYLNEHIH TLGKELQKPI MLMPDAELSG LHLANLTHFS PHYLLATHSS AGSTRLLLLS 480
  481 YKDNDNKPGE WFYRVHSSVR INGLVNAVAV APYAMNEFYV QTVNNGHTYE VSLKADKTLK 540
  541 VERSYVQLHE PADQIDWVIV KGCIWDGYTG ALVTLRNQHL LHIDGYRIGE DVTSFCVVTN 600
  601 YLVYTQLNAM HFVQLDDRRQ VASRNIERGA KIVTAVARKA RVVLQLPRGN LEAICPRVLV 660
  661 LELVGDLLER GKYQKAIEMS RKQRINLNII FDHDVKRFVS SVGAFLNDIN EPQWLCLFLS 720
  721 ELQNEDFTKG MYSSNYDASK QTYPSDYRVD QKVEYVCRLL EQQMNRFVSR FRLPLITAYV 780
  781 KLGCLEMALQ VIWKEQQEDA SLADQLLQHL LYLVDVNDLY NVALGTYDFG LVLFVAQKSQ 840
  841 KDPKEFLPYL NDLKALPIDY RKFRIDDHLK RYTSALSHLA ACGEQHYEEA LEYIRKHGLY 900
  901 TDGLAFYREH IEFQKNIYVA YADHLRAIAK LDNASLMYER GGQLQQALLS AKHTLDWQRV 960
  961 LVLAKKLSEP LDQVAQSLVG PLQQQGRHME AYELVKEHCQ DRKRQFDVLL EGHLYSRAIY1020
 1021 EAGLEDDDVS EKIAPALLAY GVQLESSLQA DLQLFLDYKQ RLLDIRRNQA KSGEGYIDTD1080
 1081 VNLKEVDLLS DTTSLHSSQY SGTSRRTGKT FRSSKNRRKH ERKLFSLKPG NPFEDIALID1140
 1141 ALHNHVTKIA QQQQPVRDTC KALLQLANAA DADPLAAALQ REFKTLLQAV DAALDEIWTP1200
 1201 ELRGNGLMAD HLTGPNVDYL ALQKEQRYAL LSPLKRFKPQ LIMMDWQHEI LQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..481] PSI-BLAST 49.522879 Actin interacting protein 1
    2 View Details [482..669] PSI-BLAST 3.39794 Structure of a putative isomerase from E. coli
    3 View Details [670..1081] PSI-BLAST 10.30103 The superhelical TPR domain of O-linked GlcNAc transferase reveals structural similarities to importin alpha.
    4 View Details [1082..1252] MSA 1.101965 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • general RNA polymerase II transcription factor activity
    		•  2.99343906593123 bayes_pls_golite062009
  • snoRNA binding
    		•  2.77952316953921 bayes_pls_golite062009
  • binding
    		•  2.42570478946173 bayes_pls_golite062009
    		• 2.40807791198019 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.3610959773142 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.30918780727915 bayes_pls_golite062009
  • DNA binding
    		•  1.71685536470455 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.5281054405163 bayes_pls_golite062009
  • kinase activity
    		•  1.5053563627859 bayes_pls_golite062009
  • RNA binding
    		•  1.50295916950465 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.33036729957356 bayes_pls_golite062009
  • protein kinase activity
    		•  1.3214585007945 bayes_pls_golite062009
  • protein binding
    		•  1.21879977456466 bayes_pls_golite062009
  • transcription factor activity
    		•  1.08768505897883 bayes_pls_golite062009
  • ligase activity
    		•  0.93058496790047 bayes_pls_golite062009
  • transferase activity
    		•  0.913674310517261 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.722742354759599 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.676924760416604 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.658573452658359 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.618638900707402 bayes_pls_golite062009
  • transcription factor binding
    		•  0.489473003915035 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.30761651528651 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  0.28606552120995 bayes_pls_golite062009
  • transcription initiation factor activity
    		•  0.262596110845942 bayes_pls_golite062009
  • structural molecule activity
    		•  0.254012051644049 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.182612389752591 bayes_pls_golite062009
  • chromatin binding
    		•  0.151977098745772 bayes_pls_golite062009
  • actin binding
    		•  0.00606924241186668 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
  • binding
    		•  2.71974493738804 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.36571535004008 bayes_pls_golite062009
  • transcription elongation regulator activity
    		•  2.11470671770795 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.03244296439384 bayes_pls_golite062009
  • DNA binding
    		•  1.95874073664777 bayes_pls_golite062009
  • protein binding
    		•  1.6279032205159 bayes_pls_golite062009
  • RNA polymerase II transcription elongation factor activity
    		•  1.2408748355559 bayes_pls_golite062009
  • transcription factor activity
    		•  1.21805666483342 bayes_pls_golite062009
  • transferase activity
    		•  1.14940839435601 bayes_pls_golite062009
  • ligase activity
    		•  0.825764637499128 bayes_pls_golite062009
  • transcription factor binding
    		•  0.518146612491969 bayes_pls_golite062009
  • RNA binding
    		•  0.497066934302855 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.30464889749774 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.116119418380222 bayes_pls_golite062009
  • transcription activator activity
    		•  0.0593768116971065 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle