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View Structure Prediction Details

Protein: CG10535-PA
Organism: Drosophila melanogaster
Length: 1252 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CG10535-PA.

Description E-value Query
Range
Subject
Range
gi|21428994 - gi|21428994|gb|AAM50216.1| GM13228p [Drosophila melanogaster]
806.0 [0..107] [1252..1]

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Predicted Domain #1
Region A:
Residues: [1-481]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRNLKLRYCK ELNAVAHPQH LLLQPELNGG ASDIYFVVAD NKIYAVQESG DVRLKVIADL  60
   61 PDIVGVEFLQ LDNAICVASG AGEVILVDPQ TGATSEGTFC DVGIESMAWS PNQEVVAFVT 120
  121 RTHNVVLMTS TFDVIAEQPL DAELDPDQQF VNVGWGKKET QFHGSEGKQA AKQKESDSTF 180
  181 IRDEQELNQD VSISWRGDGE FFVVSYVAAQ LGRTFKVYDS EGKLNHTAEK SANLKDSVVW 240
  241 RPTGNWIAVP QQFPNKSTIA LFEKNGLRHR ELVLPFDLQE EPVVQLRWSE DSDILAIRTC 300
  301 AKEEQRVYLY TIGNYHWYLK QVLIFEQADP LALLHWDTRC GAEHTLHVLK ESGKHLVYRW 360
  361 AFAVDRNNSI VGVIDGKRLL LTDFDEAIVP PPMSKIVLKF ETYINAFISH GTSLWVYTCD 420
  421 RKIYLNEHIH TLGKELQKPI MLMPDAELSG LHLANLTHFS PHYLLATHSS AGSTRLLLLS 480
  481 Y

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 49.522879
Match: 1nr0A
Description: Actin interacting protein 1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
general RNA polymerase II transcription factor activity 2.99343906593123 bayes_pls_golite062009
snoRNA binding 2.77952316953921 bayes_pls_golite062009
binding 2.42570478946173 bayes_pls_golite062009
2.40807791198019 bayes_pls_golite062009
transcription regulator activity 2.3610959773142 bayes_pls_golite062009
nucleic acid binding 2.30918780727915 bayes_pls_golite062009
DNA binding 1.71685536470455 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.5281054405163 bayes_pls_golite062009
kinase activity 1.5053563627859 bayes_pls_golite062009
RNA binding 1.50295916950465 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.33036729957356 bayes_pls_golite062009
protein kinase activity 1.3214585007945 bayes_pls_golite062009
protein binding 1.21879977456466 bayes_pls_golite062009
transcription factor activity 1.08768505897883 bayes_pls_golite062009
ligase activity 0.93058496790047 bayes_pls_golite062009
transferase activity 0.913674310517261 bayes_pls_golite062009
cytoskeletal protein binding 0.722742354759599 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.676924760416604 bayes_pls_golite062009
transcription repressor activity 0.658573452658359 bayes_pls_golite062009
protein serine/threonine kinase activity 0.618638900707402 bayes_pls_golite062009
transcription factor binding 0.489473003915035 bayes_pls_golite062009
transcription cofactor activity 0.30761651528651 bayes_pls_golite062009
nucleotidyltransferase activity 0.28606552120995 bayes_pls_golite062009
transcription initiation factor activity 0.262596110845942 bayes_pls_golite062009
structural molecule activity 0.254012051644049 bayes_pls_golite062009
transcription corepressor activity 0.182612389752591 bayes_pls_golite062009
chromatin binding 0.151977098745772 bayes_pls_golite062009
actin binding 0.00606924241186668 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [482-669]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KDNDNKPGEW FYRVHSSVRI NGLVNAVAVA PYAMNEFYVQ TVNNGHTYEV SLKADKTLKV  60
   61 ERSYVQLHEP ADQIDWVIVK GCIWDGYTGA LVTLRNQHLL HIDGYRIGED VTSFCVVTNY 120
  121 LVYTQLNAMH FVQLDDRRQV ASRNIERGAK IVTAVARKAR VVLQLPRGNL EAICPRVLVL 180
  181 ELVGDLLE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.39794
Match: 1ri6A
Description: Structure of a putative isomerase from E. coli
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [670-1081]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RGKYQKAIEM SRKQRINLNI IFDHDVKRFV SSVGAFLNDI NEPQWLCLFL SELQNEDFTK  60
   61 GMYSSNYDAS KQTYPSDYRV DQKVEYVCRL LEQQMNRFVS RFRLPLITAY VKLGCLEMAL 120
  121 QVIWKEQQED ASLADQLLQH LLYLVDVNDL YNVALGTYDF GLVLFVAQKS QKDPKEFLPY 180
  181 LNDLKALPID YRKFRIDDHL KRYTSALSHL AACGEQHYEE ALEYIRKHGL YTDGLAFYRE 240
  241 HIEFQKNIYV AYADHLRAIA KLDNASLMYE RGGQLQQALL SAKHTLDWQR VLVLAKKLSE 300
  301 PLDQVAQSLV GPLQQQGRHM EAYELVKEHC QDRKRQFDVL LEGHLYSRAI YEAGLEDDDV 360
  361 SEKIAPALLA YGVQLESSLQ ADLQLFLDYK QRLLDIRRNQ AKSGEGYIDT DV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.30103
Match: 1w3bA
Description: The superhelical TPR domain of O-linked GlcNAc transferase reveals structural similarities to importin alpha.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.71974493738804 bayes_pls_golite062009
transcription regulator activity 2.36571535004008 bayes_pls_golite062009
transcription elongation regulator activity 2.11470671770795 bayes_pls_golite062009
nucleic acid binding 2.03244296439384 bayes_pls_golite062009
DNA binding 1.95874073664777 bayes_pls_golite062009
protein binding 1.6279032205159 bayes_pls_golite062009
RNA polymerase II transcription elongation factor activity 1.2408748355559 bayes_pls_golite062009
transcription factor activity 1.21805666483342 bayes_pls_golite062009
transferase activity 1.14940839435601 bayes_pls_golite062009
ligase activity 0.825764637499128 bayes_pls_golite062009
transcription factor binding 0.518146612491969 bayes_pls_golite062009
RNA binding 0.497066934302855 bayes_pls_golite062009
transcription cofactor activity 0.30464889749774 bayes_pls_golite062009
transcription coactivator activity 0.116119418380222 bayes_pls_golite062009
transcription activator activity 0.0593768116971065 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [1082-1252]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NLKEVDLLSD TTSLHSSQYS GTSRRTGKTF RSSKNRRKHE RKLFSLKPGN PFEDIALIDA  60
   61 LHNHVTKIAQ QQQPVRDTCK ALLQLANAAD ADPLAAALQR EFKTLLQAVD AALDEIWTPE 120
  121 LRGNGLMADH LTGPNVDYLA LQKEQRYALL SPLKRFKPQL IMMDWQHEIL Q

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle