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Protein Overview: Mcm5-PA

General Information:
Name(s) found: Mcm5-PA / FBpp0081756 [FlyBase]
Description(s) found:
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  • gi|7299365|gb|AAF54557.1| minichromosome maintenance 5 [Drosophila melanogaster] [NCBI NR]
  • gi|24645774|ref|NP_524308.2| minichromosome maintenance 5 [Drosophila melanogaster] [NCBI NR]
  • gi|17946434|gb|AAL49250.1| RE67590p [Drosophila melanogaster] [NCBI NR]
  • DNA replication licensing factor Mcm5 OS=Drosophila melanogaster GN=Mcm5 PE=1 SV=1 [Swiss-Prot]
  • The gene Minichromosome maintenance 5 is referred to in FlyBase by the symbol Dmel\Mcm5 (CG4082, FBgn0017577). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:6614250..6616898. It has the cytological map location 86C6. There is experimental evidence that it has the molecular function</span>: 3'-5' DNA helicase activity. There is experimental evidence that it is involved in the biological process</span>: meiosis; resolution of meiotic recombination intermediates; chromosome condensation; DNA endoreduplication. 20 alleles are reported. The phenotypes of these alleles are annotated with: nuclear chromosome; imaginal disc. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG4082-PA translation from_gene[CG4082 Mcm5 FBgn0017577] seq_release:3 mol_weight=82259 cds_boundaries:(3R:6,614,405..6,616,778[+]) aa_length:733 transcript_info:[CG4082-RA seq_release:3] gene_info:[gene symbol:Mcm5 FBgn0017577 gene_boundaries:(3R:6,6 [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9VGW6) MCM5 protein (RE67590p) [DrosMelano7227.FASTAC.txt]
  • (AE003688) Mcm5 gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG4082-PA [Drosophila melanogaster]gi|17946434|gb|AAL49250.1| RE67590p [Drosophila melanogaster]gi|24645774|ref|NP_524308.2| CG4082-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3R:join(6614387..6614538,6614593..6615703,6615762..6616583,6616647..6616763); ID=FBpp0081756; name=Mcm5-PA; parent=FBgn0017577,FBtr0082279; dbxref=FlyBase:FBpp0081756,FlyBase_Annotation_IDs:CG4082-PA,GB_protein:AAF54557.1,REFSEQ:NP_52430 [fly-100309-contam.fasta]
  • CG4082-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Minichromosome maintenance 5 CG4082-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • RE67590p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=3R:join(6614387..6614538,6614593..6615703,6615762..6616583,6616647..6616763); ID=FBpp0081756; name=Mcm5-PA; parent=FBgn0017577,FBtr0082279; dbxref=FlyBase:FBpp0081756,FlyBase_Annotation_IDs:CG4082-PA,GB_protein:AAF54557.1,REFSEQ:NP_524308,GB_protein:AAF54557; MD5=c31cf18c8eb9dce8113bd703a82b860a; length=733; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:join(6614387..6614538,6614593..6615703,6615762..6616583,6616647..6616763); ID=FBpp0081756; name=Mcm5-PA; parent=FBgn0017577,FBtr0082279; dbxref=FlyBase:FBpp0081756,FlyBase_Annotation_IDs:CG4082-PA,GB_protein:AAF54557.1,REFSEQ:NP_524308,GB_protein:AAF54557; MD5=c31cf18c8eb9dce8113bd703a82b860a; length=733; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • type=protein; loc=3R:join(6614387..6614538,6614593..6615703,6615762..6616583,6616647..6616763); ID=FBpp0081756; name=Mcm5-PA; parent=FBgn0017577,FBtr0082279; dbxref=FlyBase:FBpp0081756,FlyBase_Annotation_IDs:CG4082-PA,GB_protein:AAF54557.1,REFSEQ:NP_524308,GB_protein:AAF54557,FlyMine:FBpp0081756,modMine:FBpp0081756; MD5=c31cf18c8eb9dce8113bd703a82b860a; length=733; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=3R:join(10788665..10788816,10788871..10789981,10790040..10790861,10790925..10791041); ID=FBpp0081756; name=Mcm5-PA; parent=FBgn0017577,FBtr0082279; dbxref=FlyBase:FBpp0081756,FlyBase_Annotation_IDs:CG4082-PA,GB_protein:AAF54557.1,REFSEQ:NP_524308,GB_protein:AAF54557,FlyMine:FBpp0081756,modMine:FBpp0081756; MD5=c31cf18c8eb9dce8113bd703a82b860a; length=733; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3R:join(10788665..10788816,10788871..10789981,10790040..10790861,10790925..10791041); ID=FBpp0081756; name=Mcm5-PA; parent=FBgn0017577,FBtr0082279; dbxref=FlyBase:FBpp0081756,FlyBase_Annotation_IDs:CG4082-PA,GB_protein:AAF54557.1,REFSEQ:NP_524308,GB_protein:AAF54557,FlyMine:FBpp0081756,modMine:FBpp0081756; MD5=c31cf18c8eb9dce8113bd703a82b860a; length=733; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FBpp0081756 type=protein; loc=3R:join(10788665..10788816,10788871..10789981,10790040..10790861,10790925..10791041); ID=FBpp0081756; name=Mcm5-PA; parent=FBgn0017577,FBtr0082279; dbxref=FlyBase:FBpp0081756,FlyBase_Annotation_IDs:CG4082-PA,GB_protein:AAF54557.1,REFSEQ:NP_524308,GB_protein:AAF54557,FlyMine:FBpp0081756,modMine:FBpp0081756; MD5=c31cf18c8eb9dce8113bd703a82b860a; length=733; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=3R:join(10788665..10788816,10788871..10789981,10790040..10790861,10790925..10791041); ID=FBpp0081756; name=Mcm5-PA; parent=FBgn0017577,FBtr0082279; dbxref=FlyBase:FBpp0081756,FlyBase_Annotation_IDs:CG4082-PA,GB_protein:AAF54557.1,REFSEQ:NP_524308,GB_protein:AAF54557,UniProt/Swiss-Prot:Q9VGW6,FlyMine:FBpp0081756,modMine:FBpp0081756; MD5=c31cf18c8eb9dce8113bd703a82b860a; length=733; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 733 amino acids

    Gene Ontology:
    Cellular Component: pre-replicative complex [ISS]
    Biological Process: DNA replication initiation [IEA]
    DNA replication [IEA]
    chromosome condensation [IMP]
    pre-replicative complex assembly [ISS]
    resolution of meiotic recombination intermediates [IMP]
    DNA endoreduplication [IMP]
    meiosis [IMP]
    Molecular Function: DNA binding [IEA]
    ATP binding [IEA]
    chromatin binding [ISS]
    3'-5' DNA helicase activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEGFDDAGVF FSDNFGGDNQ QDAQINLQAV KKKYKEFIRT FNEENFFYKY RDTLKRNYLN  60
   61 GRYFLEIEME DLVGFDETLA DKLNKQPTEH LEIFEEAARE VADEITAPRP EHEEHMHDIQ 120
  121 ILLSSNANPT NIRQLKSDCV SKLVKIAGII VAASGISAKA TRMSIQCLSC STVIPNLKVN 180
  181 PGLEGYALPR KCNTEQAGRP KCPLDPFFIM PDKCKCVDFQ TLKLQELPDF VPQGEIPRHL 240
  241 QLFCDRSLCE RVVPGNRVLI QGIYSIRKVG KPSRRDGREK AVVGVRAPYM RVVGITVDSE 300
  301 GAGAISRYSN ITSDEEEHFR RMAASGDIYE RLSQSLAPSI FGSRDIKKAI TCMLFGGSRK 360
  361 RLPDGLCRRG DINVLLLGDP GTAKSQLLKF VEKVAPIAVY TSGKGSSAAG LTASVMKDPQ 420
  421 TRNFVMEGGA MVLADGGVVC IDEFDKMRED DRVAIHEAME QQTISIAKAG ITTTLNSRCS 480
  481 VLAAANSIFG RWDDTKGEEN IDFMPTILSR FDMIFIVKDI HDESRDITLA KHIINVHLSS 540
  541 NKSAPSEPAE GEISLSTFKK YIHYCRTHCG PRLSEAAGEK LKSRYVLMRS GAGQQEKASD 600
  601 KRLSIPITVR QLEAVIRISE SLAKIRLQPF ATDEHVNEAL RLFQVSTLDA AMTGSLAGAE 660
  661 GFTTEEDQET LNRIEKQLKR RFAIGSQVSE QNILQDFLRQ KYEERTVMKV IHTMIRRGEL 720
  721 QHRMQRKMLY RIC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..302] PSI-BLAST 43.39794 DNA replication initiator (cdc21/cdc54) N-terminal domain
    2 View Details [303..733] PSI-BLAST 18.221849 No description for 2dhrA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • telomeric DNA binding
    		•  4.81350293592083 bayes_pls_golite062009
  • telomerase inhibitor activity
    		•  4.48082903165152 bayes_pls_golite062009
  • single-stranded telomeric DNA binding
    		•  4.34033743483519 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.29626483284963 bayes_pls_golite062009
  • DNA binding
    		•  3.71771169141041 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  3.51998515668903 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  3.48139490984491 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  3.43027351695641 bayes_pls_golite062009
  • structural molecule activity
    		•  3.29857127235306 bayes_pls_golite062009
  • binding
    		•  2.83465364476231 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.10110937001387 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.9581702424972 bayes_pls_golite062009
  • DNA replication origin binding
    		•  1.84819558112187 bayes_pls_golite062009
  • translation regulator activity
    		•  1.46320772716954 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  1.40718318783582 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.30343463892105 bayes_pls_golite062009
  • translation initiation factor activity
    		•  1.27539679024898 bayes_pls_golite062009
  • transcription activator activity
    		•  1.24141936405635 bayes_pls_golite062009
  • protein binding
    		•  1.20309946451799 bayes_pls_golite062009
  • RNA polymerase activity
    		•  1.19766815287926 bayes_pls_golite062009
  • DNA-directed RNA polymerase activity
    		•  1.19766815287926 bayes_pls_golite062009
  • ribonuclease activity
    		•  1.19236946227657 bayes_pls_golite062009
  • transcription factor activity
    		•  1.14242112812892 bayes_pls_golite062009
  • DNA helicase activity
    		•  1.12203697857261 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.638831894247026 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.635129001787169 bayes_pls_golite062009
  • nuclease activity
    		•  0.57381531077345 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  0.474251377131502 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  0.47336621289748 bayes_pls_golite062009
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  0.47336621289748 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  0.325774164899685 bayes_pls_golite062009
  • four-way junction helicase activity
    		•  0.31769813397725 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.314881439089948 bayes_pls_golite062009
  • exonuclease activity
    		•  0.28313884527829 bayes_pls_golite062009
  • transferase activity
    		•  0.249054945579328 bayes_pls_golite062009
  • RNA binding
    		•  0.18502033889261 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  0.125256208482441 bayes_pls_golite062009
  • exoribonuclease activity
    		•  0.109774918833391 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  0.0954216620147701 bayes_pls_golite062009
  • DEAD/H-box RNA helicase binding
    		•  0.0627405398613412 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  0.0179535526984695 bayes_pls_golite062009
  • helicase activity
    		•  0.0121541775159524 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle