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Protein Overview: dsx-PA, FBpp0303106

General Information:
Name(s) found: FBpp0303106 [FlyBase]
dsx-PA / FBpp0081256 [FlyBase]
Description(s) found:
Found 30 descriptions.
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  • type=protein; loc=3R:complement(3755952..3756409,3761490..3761627,3785474..3786527); ID=FBpp0303106; name=dsx-PD; parent=FBgn0000504,FBtr0330073; dbxref=FlyBase:FBpp0303106,FlyBase_Annotation_IDs:CG11094-PD,REFSEQ:NP_001262352,GB_protein:AGB95734; MD5=991785ce39c4f50b28271b0bf2189f88; length=549; release=r5.56; species=Dmel; [FlyBase]
  • The gene doublesex is referred to in FlyBase by the symbol Dmel\dsx (CG11094, FBgn0000504). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:3750045..3793130. It has the cytological map location 84E5-84E6. There is experimental evidence that it has the molecular function</span>: protein binding; protein homodimerization activity. There is experimental evidence that it is involved in the biological process</span>: imaginal disc-derived female genitalia development; imaginal disc-derived male genitalia development; genital disc development. 116 alleles are reported. The phenotypes of these alleles are annotated with 26 unique terms, many of which group under: organ system; adult segment; region of integument; adult; peripheral nervous system; imaginal precursor; nervous system; hub cell; larval abdominal segment 8; male accessory gland; female genitalia; external compound sense organ; female germline cyst. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 549 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS]
    Biological Process: genital disc sexually dimorphic development [TAS]
    male courtship behavior [TAS]
    transcription from RNA polymerase II promoter [NAS]
    sex determination [NAS][TAS]
    positive regulation of transcription from RNA polymerase II promoter [TAS]
    regulation of transcription [TAS]
    behavior [TAS]
    nuclear mRNA splicing, via spliceosome [TAS]
    negative regulation of transcription from RNA polymerase II promoter [TAS]
    regulation of imaginal disc growth [TAS]
    sex differentiation [NAS][TAS]
    negative regulation of developmental pigmentation [TAS]
    male analia development [NAS]
    negative regulation of transcription, DNA-dependent [NAS]
    female analia development [NAS]
    positive regulation of transcription, DNA-dependent [NAS]
    female sex differentiation [TAS]
    male sex differentiation [TAS]
    male somatic sex determination [NAS]
    female somatic sex determination [NAS][TAS]
    somatic sex determination [NAS][TAS]
    genital disc development [IMP][TAS]
    genital disc morphogenesis [TAS]
    spermatogenesis [NAS]
    regulation of transcription, DNA-dependent [IEA]
    imaginal disc-derived male genitalia development [IGI][NAS]
    sex comb development [TAS]
    male courtship behavior, veined wing generated song production [NAS][TAS]
    imaginal disc-derived female genitalia development [IGI][NAS]
    central nervous system development [TAS]
    courtship behavior [NAS]
    sex-specific pigmentation [NAS][TAS]
    Molecular Function: DNA binding [NAS][TAS]
    zinc ion binding [NAS]
    transcription factor activity [IEA][NAS]
    protein homodimerization activity [IDA]
    protein binding [IPI]
    RNA polymerase II transcription factor activity [TAS]
    transcription regulator activity [TAS]
    specific RNA polymerase II transcription factor activity [ISS][NAS]
    mRNA binding [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVSEENWNSD TMSDSDMIDS KNDVCGGASS SSGSSISPRT PPNCARCRNH GLKITLKGHK  60
   61 RYCKFRYCTC EKCRLTADRQ RVMALQTALR RAQAQDEQRA LHMHEVPPAN PAATTLLSHH 120
  121 HHVAAPAHVH AHHVHAHHAH GGHHSHHGHV LHHQQAAAAA AAAPSAPASH LGGSSTAASS 180
  181 IHGHAHAHHV HMAAAAAASV AQHQHQSHPH SHHHHHQNHH QHPHQQPATQ TALRSPPHSD 240
  241 HGGSVGPATS SSGGGAPSSS NAAAATSSNG SSGGGGGGGG GSSGGGAGGG RSSGTSVITS 300
  301 ADHHMTTVPT PAQSLEGSCD SSSPSPSSTS GAAILPISVS VNRKNGANVP LGQDVFLDYC 360
  361 QKLLEKFRYP WELMPLMYVI LKDADANIEE ASRRIEEARV EINRTVAQIY YNYYTPMALV 420
  421 NGAPMYLTYP SIEQGRYGAH FTHLPLTQIC PPTPEPLALS RSPSSPSGPS AVHNQKPSRP 480
  481 GSSNGTVHSA ASPTMVTTMA TTSSTPTLSR RQRSRSATPT TPPPPPPAHS SSNGAYHHGH 540
  541 HLVSSTAAT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..102] PSI-BLAST 27.09691 DM domain of Doublesex (dsx)
    2 View Details [103..341] MSA 5.171995 View MSA. No confident structure predictions are available.
    3 View Details [342..420] FFAS03 3.97 Crystal structure of the dimerization domain of doublesex protein from D. melanogaster
    4 View Details [421..549] MSA 6.158993 View MSA. No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.87

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle