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Protein Overview: ftz-PA

General Information:
Name(s) found: ftz-PA / FBpp0081139 [FlyBase]
Description(s) found:
Found 25 descriptions.
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  • The gene fushi tarazu is referred to in FlyBase by the symbol Dmel\ftz (CG2047, FBgn0001077). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:2690046..2691950. It has the cytological map location 84A6. There is experimental evidence that it has the molecular function</span>: sequence-specific DNA binding; transcription repressor activity. There is experimental evidence that it is involved in the biological process</span>: segmentation; regulation of transcription; gonadal mesoderm development; germ cell migration; negative regulation of transcription, DNA-dependent. 193 alleles are reported. The phenotypes of these alleles are annotated with 73 unique terms, many of which group under: organ system; adult segment; developing anatomical structure; abdominal ventral denticle belt; embryonic segment; thoracic segment; embryonic abdomen; prothoracic segment; adult; nervous system. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 410 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IC][IEA][NAS]
    Biological Process: posterior head segmentation [TAS]
    segmentation [IMP]
    blastoderm segmentation [TAS]
    periodic partitioning by pair rule gene [NAS][TAS]
    regulation of transcription, DNA-dependent [IEA][ISS]
    trunk segmentation [TAS]
    germ cell migration [IMP]
    regulation of transcription [IEA][IMP]
    regulation of transcription from RNA polymerase II promoter [NAS]
    gonadal mesoderm development [IMP]
    central nervous system development [TAS]
    negative regulation of transcription, DNA-dependent [IDA]
    cell fate specification [TAS]
    Molecular Function: transcription factor activity [ISS]
    sequence-specific DNA binding [IDA]
    transcription repressor activity [IDA][IMP]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATTNSQSHY SYADNMNMYN MYHPHSLPPT YYDNSGSNAY YQNTSNYQGY YPQESYSESC  60
   61 YYYNNQEQVT TQTVPPVQPT TPPPKATKRK AEDDAASIIA AVEERPSTLR ALLTNPVKKL 120
  121 KYTPDYFYTT VEQVKKAPAV STKVTASPAP SYDQEYVTVP TPSASEDVDY LDVYSPQSQT 180
  181 QKLKNGDFAT PPPTTPTSLP PLEGISTPPQ SPGEKSSSAV SQEINHRIVT APNGAGDFNW 240
  241 SHIEETLASD CKDSKRTRQT YTRYQTLELE KEFHFNRYIT RRRRIDIANA LSLSERQIKI 300
  301 WFQNRRMKSK KDRTLDSSPE HCGAGYTAML PPLEATSTAT TGAPSVPVPM YHHHQTTAAY 360
  361 PAYSHSHSHG YGLLNDYPQQ QTHQQYDAYP QQYQHQCSYQ QHPQDLYHLS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..176] MSA 12.525996 View MSA. No confident structure predictions are available.
    2 View Details [177..248] deduced N/A No confident structure predictions are available.
    3 View Details [249..332] PSI-BLAST 23.39794 DETERMINATION OF THE THREE-DIMENSIONAL STRUCTURE OF THE ANTENNAPEDIA HOMEODOMAIN FROM DROSOPHILA IN SOLUTION BY 1H NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
    4 View Details [333..410] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  5.13863038737912 bayes_pls_golite062009
  • DNA binding
    		•  4.66369707598026 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.51452285155271 bayes_pls_golite062009
  • transcription factor activity
    		•  4.06706589695599 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.16896789933192 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.41271657675151 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.91962622287073 bayes_pls_golite062009
  • transcription activator activity
    		•  1.77700860354597 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.73068440195944 bayes_pls_golite062009
  • chromatin binding
    		•  1.68956710349366 bayes_pls_golite062009
  • transcription factor binding
    		•  1.40653841901929 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.84983974758882 bayes_pls_golite062009
  • protein binding
    		•  0.830419844171551 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.25931464844298 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle