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Protein Overview: Hdac3-PA

General Information:
Name(s) found: Hdac3-PA / FBpp0078414 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene Histone deacetylase 3 is referred to in FlyBase by the symbol Dmel\Hdac3 (CG2128, FBgn0025825). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:1298532..1300320. It has the cytological map location 83A4. There is experimental evidence that it has the molecular function</span>: histone deacetylase activity. There is experimental evidence that it is involved in the biological process</span>: negative regulation of apoptosis; regulation of transcription; chromatin silencing. 7 alleles are reported. The phenotype of these alleles is annotated with: wing. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 438 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    cytoplasm [IDA]
    Biological Process: negative regulation of apoptosis [IMP]
    chromatin silencing [IGI][IMP]
    histone deacetylation [IEA]
    regulation of transcription [IDA]
    Molecular Function: histone deacetylase activity [IDA][ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTDRRVSYFY NADVGNFHYG AGHPMKPQRL AVTHSLVMNY GLHKKMKIYR PYKASAQDML  60
   61 RFHSDEYIAY LQQVTPQNIQ CNSVAYTKYL AHFSVGEDCP VFDGLFDFCA MYTGASLEGA 120
  121 QKLNHNHSDI CINWSGGLHH AKKFEASGFC YVNDIVIGIL ELLKYHPRVL YIDIDVHHGD 180
  181 GVQEAFYLTD RVMTASFHKY GNYFFPGTGD MYEIGAESGR YYSVNVPLKE GIDDQSYFQV 240
  241 FKPIISAIMD FYRPTAIVLQ CGADSLAGDR LGCFSLSTKG HGECVKFVKE LNVPTLVVGG 300
  301 GGYTLRNVAR CWTHETSLLV DQDIENDLPA TEYYDFFAPD FTLHPEINSR QDNANSKQYL 360
  361 ELIVKHVYEN LKMCQHSPSV QMVQTPPDVD LEELRSNREE ASDPDVRISV ADEDKLVDAK 420
  421 NEFYDGDQDQ DKPDSAES

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..438] PSI-BLAST 92.154902 Crystal Structure of human HDAC8 complexed with Trichostatin A

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein deacetylase activity
    		•  12.8220438463909 bayes_pls_golite062009
  • histone deacetylase activity
    		•  12.6231784270509 bayes_pls_golite062009
  • deacetylase activity
    		•  11.5037545953213 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
    		•  9.39837596691907 bayes_pls_golite062009
  • histone deacetylase activity (H3-K16 specific)
    		•  6.99181745976945 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  5.91624581343504 bayes_pls_golite062009
  • histone deacetylase activity (H3-K14 specific)
    		•  4.16874113003585 bayes_pls_golite062009
  • histone methyltransferase activity (H3-K27 specific)
    		•  3.8227021325477 bayes_pls_golite062009
  • agmatinase activity
    		•  3.73238467801147 bayes_pls_golite062009
  • histone deacetylase activity (H3-K9 specific)
    		•  3.65015413158247 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.49362347258099 bayes_pls_golite062009
  • NAD-dependent protein deacetylase activity
    		•  3.35999169984456 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity
    		•  3.35999169984456 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.05701986980927 bayes_pls_golite062009
  • hydrolase activity
    		•  2.48411098726406 bayes_pls_golite062009
  • transcription factor binding
    		•  2.19991964087943 bayes_pls_golite062009
  • NAD-independent histone deacetylase activity
    		•  2.1026758793482 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.09632179671955 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.98907367314887 bayes_pls_golite062009
  • DNA binding
    		•  1.982290944939 bayes_pls_golite062009
  • binding
    		•  1.948738669065 bayes_pls_golite062009
  • protein binding
    		•  1.77599011146146 bayes_pls_golite062009
  • catalytic activity
    		•  1.68836803454021 bayes_pls_golite062009
  • histone methyltransferase activity (H3-K9 specific)
    		•  1.48241147541212 bayes_pls_golite062009
  • specific transcriptional repressor activity
    		•  1.37118634909958 bayes_pls_golite062009
  • arginase activity
    		•  1.34373529002692 bayes_pls_golite062009
  • transcription activator activity
    		•  1.31578100431097 bayes_pls_golite062009
  • transcription factor activity
    		•  1.24596588472933 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
    		•  1.01223037319069 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.84972377395539 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  0.396822865624511 bayes_pls_golite062009
  • transferase activity
    		•  0.323230424038105 bayes_pls_golite062009
  • chromatin binding
    		•  0.104097933861351 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle