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Protein Overview: Karybeta3-PA, FB...

General Information:
Name(s) found: FBpp0307568 [FlyBase]
Karybeta3-PA / FBpp0078500 [FlyBase]
Description(s) found:
Found 26 descriptions.
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  • type=protein; loc=3R:join(475409..475489,476307..476456,476521..477615,477705..479058,479174..479811); ID=FBpp0307568; name=Karybeta3-PB; parent=FBgn0087013,FBtr0336462; dbxref=REFSEQ:NP_001262259,GB_protein:AGB95642,FlyBase:FBpp0307568,FlyBase_Annotation_IDs:CG1059-PB; MD5=159db4c67d28d8e2289d4cf0d9f0283a; length=1105; release=r5.56; species=Dmel; [FlyBase]
  • The gene Karyopherin Ã?&#142;Ã?² 3 is referred to in FlyBase by the symbol Dmel\KaryÃ?&#142;Ã?²3 (CG1059, FBgn0087013). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:474945..480360. It has the cytological map location 82C5. Based on sequence similarity, it is predicted to have molecular function</span>: protein transmembrane transporter activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: protein import into nucleus. 19 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1105 amino acids

    Gene Ontology:
    Cellular Component: cytosol [IDA]
    nuclear pore [ISS]
    Biological Process: protein import into nucleus [ISS]
    Molecular Function: protein transmembrane transporter activity [ISS]
    binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAADQAHFQQ LLASLLSTDN DVRQQAEEAY NNLSRELKVT HLLGNIQNGQ QSEEARQMAA  60
   61 VLLRRLFTTE FFDFYKGLPA ESQNQLLQQI LLAVQQEVTP QLRRKICEVV AEVARNLIDE 120
  121 DCNNQWPDIL QFLFQCANSP TPQLQESALR IFSSVPSIFG NQEAQYIDLI KQMLAKSMDA 180
  181 GSDPEVRVQA VRAVGAFILY HDKENETAIH KHFADMLPRM IHITGETIEA QDDQSLLKLL 240
  241 IEMTENCPKF LRPQLEFIFE VCMKVFSSQD FEDSWRHLVL EVMVSLAENA PSMIRKRADK 300
  301 YIVALIPLIL HMMTDLDDDE NWSTADVVDD DDHSDNNVIA ESSLDRLACG LGGKIVLPLV 360
  361 MNALPVMLGH ADWKHRFAAL MAISAIGEGC HKQMEAILDE VMSGVLNFLS DPHPRVRYAA 420
  421 CNAIGQMSTD FAQTFEKKFH SQVIPGLLSL LDDVENPRVQ AHAGAALVNF SEDCPKNILT 480
  481 RYLDGIMAKL ETILNSKFKE LVEKGNKLVL EQVVTTIASV ADTCESEFVA YYDRLMPCLK 540
  541 FIIQNANSDD LRMLRGKTIE CVSLIGLAVG REKFIGDAGE VMDMLLVNHT EGGELADDDP 600
  601 QTSYLITAWA RMCKILGKQF EQYLPLVMGP VMRTATMKPE VAMLDNDEVE DIDGDVDWSF 660
  661 INLGEQQNFA IRTAGMDDKA SACEMLVCYA RELKEGFAEY AEDVVRQMLP MLKFYFHDGV 720
  721 RTAAAESLPY LLDCAKIKGP QYLEGMWMFI CPELLKVIVT EPEPDVQSEL LNSLAKCIET 780
  781 LGPNCLNEDA MKQVLEIINK YVLEHFERAD KRLAARNEED YDDGVEEELA EQDDTDVYIL 840
  841 SKIVDITHAL FQTNKAQFLP AFEQVAPHFV KLLEPSRPVA DRQWGLCVFD DLIEFCGPAC 900
  901 APYQQIFTPA LVQYVCDKAP EVRQAAAYGC GVLGQFAGEQ FAHTCAQIIP LLVQVINDPK 960
  961 AREIENISPT ENAISAFAKI LKYNNSALSN VDELIGVWFS WLPVSEDSEE AAHIYGYLCD1020
 1021 LIEGNHPVIL GANNGNLPRI VSIIAESFCT KVVEAQSATG TRMLTIVKQV ESNPEVMAAC1080
 1081 ASTLSPEQQQ ALQDAYRELA NVAPA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..821] PSI-BLAST 77.69897 No description for 2ot8A was found.
    2 View Details [822..1105] PSI-BLAST 36.522879 Crystal structure of the exportin Cse1p complexed with its cargo ( Kap60p) and RanGTP

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • protein transporter activity
    		•  4.58709163830613 bayes_pls_golite062009
  • binding
    		•  3.0667965351474 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  2.74547353635661 bayes_pls_golite062009
  • transporter activity
    		•  2.48700774379895 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.26725422172281 bayes_pls_golite062009
  • nuclear export signal receptor activity
    		•  2.13470398426489 bayes_pls_golite062009
  • nuclear localization sequence binding
    		•  1.91487015967262 bayes_pls_golite062009
  • protein binding
    		•  1.73688475473996 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.28481004323799 bayes_pls_golite062009
  • RNA binding
    		•  1.20550543134698 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.09652988954158 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.00841167631924 bayes_pls_golite062009
  • signal transducer activity
    		•  0.662662274021266 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.662662274021266 bayes_pls_golite062009
  • signal sequence binding
    		•  0.57106697498903 bayes_pls_golite062009
  • structural molecule activity
    		•  0.449804281824548 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.385452858197632 bayes_pls_golite062009
  • mRNA binding
    		•  0.37278269424461 bayes_pls_golite062009
  • DNA binding
    		•  0.309260217284589 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.252495966234234 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.248585912061178 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.226380819487924 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.217517113570989 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  0.178770060806735 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  0.175241020572885 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  0.174922130116569 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.100181463251306 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0635404099346928 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.0548082069333885 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.052195223119721 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.0405268469927988 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle