YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: Cont-PA

General Information:
Name(s) found: Cont-PA / FBpp0078557 [FlyBase]
Description(s) found:
Found 24 descriptions.
SHOW ALL
  • The gene Contactin is referred to in FlyBase by the symbol Dmel\Cont (CG1084, FBgn0037240). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:207032..212741. It has the cytological map location 82A5. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: binding. There is experimental evidence that it is involved in the biological process</span>: nerve maturation; establishment of glial blood-brain barrier; septate junction assembly; axon ensheathment. 6 alleles are reported. The phenotypes of these alleles are annotated with: salivary gland; abdominal lateral pentascolopidial chordotonal organ lch5. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1390 amino acids

    Gene Ontology:
    Cellular Component: septate junction [IDA][NAS]
    pleated septate junction [IDA]
    Biological Process: nerve maturation [IMP]
    establishment or maintenance of epithelial cell apical/basal polarity [IC]
    septate junction assembly [IMP]
    cell adhesion [ISS]
    axon ensheathment [IMP]
    establishment of glial blood-brain barrier [IMP]
    Molecular Function: binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLAKIGLLAS ILVLNLVGQI TPQFSENLPD PDPQSGQQPQ NYQPSYNKDY SPRYNPLYTG  60
   61 QQSADPNQFD NTLVDGQSPN TYKGYYDGRA GGGGLGGNVV GPGNNLGGLG PQYDPFNRNS 120
  121 IGSAGVSYRD AYTDEDNFCP EHWVSFRQTC YRFIRSPKRN WAEAKKICKA HNADLINVDN 180
  181 VEKHSFILKN LILQNQRQNR FFISARQTGP LNWVNDDNTQ LVQIEDSFSM DEQVPLENED 240
  241 LHDNRFLVQN DLNNQNINNP NQFYNSLPGT VNQRNQNNLR GFIGPNQPYG DNRYVRDRVV 300
  301 YAFSKKRDRW MFMPAYEIEL NLFICESKVL YSSDNVNIKL DDKRPYHYGL DINDMERIPR 360
  361 GPYFVKQPND TTFDVNKNRL INDVTLSCLA NGYPTPSYTW YREVYVDDRL EYQKIDPLAQ 420
  421 DRYTISGGNL IIYEPKQALD QGAYHCVAEN KFGRIRSESA HLNFGFIMEF NLKRSAETSE 480
  481 MNWGKSIFCD PPQHYPDVRY YWARDYFPNF VEEDQRVFVS RDGALYFSFI ETVDRANYSC 540
  541 TVQTLVSDTG RNGPFFPLRV TPNSNYQALI FANTFPKVFP EAPVAGDEIR LECMAFGYPI 600
  601 PSYNWTRQGL PLQRNAYTIN YGRVLIIQNA TTNDNGEYSC TITNPRKTLM KSIYINIQMR 660
  661 PQFTIPLKDM IKDYNSDVTF ICEAFAIPDA NYTWYKNAER LDPANINRDR YIIQDNVLTI 720
  721 KFLEKDKDDA MYQCGAQNQL KTSFSSAQLR VLSMKPSFKK HPLESEVYAV YNGNTTIVCD 780
  781 PEAAPRPKFQ WKKDGQVIGS GGHRRILPSG TLTISPTSRD DEGIYTCIAS NQAGTDESHA 840
  841 RVIVLQEIRF IETPPQRIVS KEHDLIFLHC EAAFDELLDI AYVWKHNGEV LKNNHDGTGR 900
  901 IIVDWNRLTV HNTSMRDAGD YECVVKSAVN EISSKTSVSI EGAPGAPGGV QVIQISKTKA 960
  961 IIEWVDGSHN GRAIRYYNIL GRTNWNRTWV NVSTHVQARE VDRYTSRQQA EVVNLTPWSA1020
 1021 YEFSVTAVND LGIGTPSAPS PIYSTYEDKP YIAPRNVGGG GGKIGDLTIT WDPLLPQEQH1080
 1081 SHGIHYKVFW KLKGAIEWAS DEIKKQDHMG VAVVNIPLNN YYTEYEVKVQ AINSVGKGPE1140
 1141 SEIAVIHSAE DMPQVAPQKP IALAYNSTCF NVTWQPIDMS RENIRGKLIG HRLKYWKTTH1200
 1201 QEEDSVYYLS RTTRNWALIV GLQPDTYYFV KVMAYNAAGE GPESERFEER TYRKAPQKPP1260
 1261 SSVHVYGINP STVRVVWRYV SPSQDEEPVE GYKVRIWESD QNMITANNTI VPIGQKLESY1320
 1321 INNLTPGKSY NMRVLAYSNG GDGRMSSPTL HFQMGKTTRN GANTRHGHNI NTALILSTLL1380
 1381 LISTFLYTSQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..468] PSI-BLAST 55.045757 No description for 2v5sA was found.
    2 View Details [469..564] PSI-BLAST 8.0 Immunoglobulin heavy chain epsilon constant domain 2, CH2-epsilon; Immunoglobulin heavy chain epsilon constant domain 3, CH3-epsilon; Immunoglobulin heavy chain epsilon constant domain 4, CH4-epsilon
    3 View Details [565..660] PSI-BLAST 79.69897 Axonin-1
    4 View Details [661..740] FFAS03 5.56 TITIN MODULE M5, N-TERMINALLY EXTENDED, NMR
    5 View Details [741..929] PSI-BLAST 35.69897 No description for 2nziA was found.
    6 View Details [930..1047] PSI-BLAST 13.221849 Solution Structure of The First Fibronectin Type III Domain of Human KIAA0343 protein
    7 View Details [1048..1152] PSI-BLAST 21.0 CRYSTAL STRUCTURE OF TANDEM TYPE III FIBRONECTIN DOMAINS FROM DROSOPHILA NEUROGLIAN AT 2.0 ANGSTROMS
    8 View Details [1153..1239] PSI-BLAST 13.69897 No description for 2ee2A was found.
    9 View Details [1240..1390] PSI-BLAST 17.0 No description for 2edxA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • telethonin binding
    		•  6.64811984458494 bayes_pls_golite062009
  • alpha-actinin binding
    		•  5.77350124471385 bayes_pls_golite062009
  • actinin binding
    		•  5.69539760434923 bayes_pls_golite062009
  • structural constituent of muscle
    		•  4.93896503565413 bayes_pls_golite062009
  • binding
    		•  3.17641566810715 bayes_pls_golite062009
  • receptor activity
    		•  3.0754311615326 bayes_pls_golite062009
  • peptide antigen binding
    		•  2.94721224577771 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.92683710723714 bayes_pls_golite062009
  • signal transducer activity
    		•  2.92683710723714 bayes_pls_golite062009
  • fibroblast growth factor 1 binding
    		•  2.81979712905308 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.79758224858792 bayes_pls_golite062009
  • protein binding
    		•  2.22855404705168 bayes_pls_golite062009
  • IgG binding
    		•  1.92633562075074 bayes_pls_golite062009
  • olfactory receptor activity
    		•  1.79502606732682 bayes_pls_golite062009
  • antigen binding
    		•  1.63189745559168 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.58610597245454 bayes_pls_golite062009
  • actin binding
    		•  1.42681407553255 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  1.36789541796983 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.32330470851159 bayes_pls_golite062009
  • fibroblast growth factor binding
    		•  1.27793818082552 bayes_pls_golite062009
  • DNA binding
    		•  1.19412627500732 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.16252234499274 bayes_pls_golite062009
  • myosin light chain kinase activity
    		•  0.87238163212 bayes_pls_golite062009
  • actin filament binding
    		•  0.760856470721016 bayes_pls_golite062009
  • collagen binding
    		•  0.729893120256353 bayes_pls_golite062009
  • growth factor binding
    		•  0.715053526402219 bayes_pls_golite062009
  • receptor binding
    		•  0.632627479346393 bayes_pls_golite062009
  • titin binding
    		•  0.599892148302011 bayes_pls_golite062009
  • integrin binding
    		•  0.599569390248921 bayes_pls_golite062009
  • protein kinase activity
    		•  0.589015157128768 bayes_pls_golite062009
  • transcription factor activity
    		•  0.54549168007511 bayes_pls_golite062009
  • fibroblast growth factor receptor activity
    		•  0.5037774536831 bayes_pls_golite062009
  • myosin heavy chain binding
    		•  0.49788128784685 bayes_pls_golite062009
  • protein complex binding
    		•  0.43131084085213 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.300034766861208 bayes_pls_golite062009
  • kinase activity
    		•  0.232190923918901 bayes_pls_golite062009
  • cell surface binding
    		•  0.213817211551667 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.182775558017364 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.0579247757286607 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.026512949804781 bayes_pls_golite062009
  • structural molecule activity
    		•  0.00139730528977644 bayes_pls_golite062009
    3 No functions predicted.
    4
    Term Confidence Notes
  • telethonin binding
    		•  6.38949638288343 bayes_pls_golite062009
  • alpha-actinin binding
    		•  5.53326178500376 bayes_pls_golite062009
  • actinin binding
    		•  5.48624955510658 bayes_pls_golite062009
  • structural constituent of muscle
    		•  4.78053264661873 bayes_pls_golite062009
  • binding
    		•  3.05950525762784 bayes_pls_golite062009
  • receptor activity
    		•  2.85791473660662 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.78201223521838 bayes_pls_golite062009
  • signal transducer activity
    		•  2.78201223521838 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.59488214915775 bayes_pls_golite062009
  • peptide antigen binding
    		•  2.59351260720134 bayes_pls_golite062009
  • fibroblast growth factor 1 binding
    		•  2.49355574348664 bayes_pls_golite062009
  • protein binding
    		•  2.15886049700791 bayes_pls_golite062009
  • olfactory receptor activity
    		•  1.57975990329228 bayes_pls_golite062009
  • IgG binding
    		•  1.57584541871373 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.54995469932689 bayes_pls_golite062009
  • actin binding
    		•  1.40773197641911 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.33341865156235 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  1.24665876791142 bayes_pls_golite062009
  • DNA binding
    		•  1.20391708320115 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.19332924581774 bayes_pls_golite062009
  • antigen binding
    		•  1.16861985653243 bayes_pls_golite062009
  • fibroblast growth factor binding
    		•  1.00587642160047 bayes_pls_golite062009
  • myosin light chain kinase activity
    		•  0.727812088393571 bayes_pls_golite062009
  • collagen binding
    		•  0.684934406852999 bayes_pls_golite062009
  • actin filament binding
    		•  0.684482417673051 bayes_pls_golite062009
  • protein kinase activity
    		•  0.605125585768526 bayes_pls_golite062009
  • receptor binding
    		•  0.560378932994877 bayes_pls_golite062009
  • transcription factor activity
    		•  0.554724181253623 bayes_pls_golite062009
  • growth factor binding
    		•  0.554438098743996 bayes_pls_golite062009
  • integrin binding
    		•  0.474366116240879 bayes_pls_golite062009
  • titin binding
    		•  0.395513709080215 bayes_pls_golite062009
  • myosin heavy chain binding
    		•  0.377234357158059 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.328985661202282 bayes_pls_golite062009
  • protein complex binding
    		•  0.268954327341866 bayes_pls_golite062009
  • kinase activity
    		•  0.268573733052192 bayes_pls_golite062009
  • fibroblast growth factor receptor activity
    		•  0.232191642090185 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.229394368927229 bayes_pls_golite062009
  • cell surface binding
    		•  0.181552455725164 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.0426518119496661 bayes_pls_golite062009
    5 No functions predicted.
    6
    Term Confidence Notes
  • telethonin binding
    		•  5.81747667416248 bayes_pls_golite062009
  • structural constituent of muscle
    		•  5.71979489668015 bayes_pls_golite062009
  • alpha-actinin binding
    		•  4.57951951779666 bayes_pls_golite062009
  • actinin binding
    		•  4.57900103206288 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  3.79244614134061 bayes_pls_golite062009
  • receptor activity
    		•  3.73567137429359 bayes_pls_golite062009
  • cytokine binding
    		•  3.58426984827737 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.5100441341515 bayes_pls_golite062009
  • signal transducer activity
    		•  3.5100441341515 bayes_pls_golite062009
  • cytokine receptor activity
    		•  3.25206686803048 bayes_pls_golite062009
  • protein binding
    		•  3.24522318184038 bayes_pls_golite062009
  • binding
    		•  3.12471204223368 bayes_pls_golite062009
  • growth factor binding
    		•  2.4970104838834 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  2.32179186005318 bayes_pls_golite062009
  • axon guidance receptor activity
    		•  2.01367445237355 bayes_pls_golite062009
  • prolactin receptor activity
    		•  1.9556649101819 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.85720106085239 bayes_pls_golite062009
  • interleukin-2 binding
    		•  1.67132604890013 bayes_pls_golite062009
  • interleukin-6 binding
    		•  1.53073516901486 bayes_pls_golite062009
  • interleukin-6 receptor activity
    		•  1.53073516901486 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.32813363771214 bayes_pls_golite062009
  • receptor binding
    		•  1.31676259534833 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.31663344632755 bayes_pls_golite062009
  • peptide hormone binding
    		•  1.2420090521345 bayes_pls_golite062009
  • actin binding
    		•  1.21472460452555 bayes_pls_golite062009
  • DNA binding
    		•  1.2006039770643 bayes_pls_golite062009
  • myosin light chain kinase activity
    		•  1.18611050638993 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  0.99058387466784 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.86564366658585 bayes_pls_golite062009
  • growth hormone receptor activity
    		•  0.840187286074179 bayes_pls_golite062009
  • cell surface binding
    		•  0.792329562040096 bayes_pls_golite062009
  • ciliary neurotrophic factor receptor activity
    		•  0.71036287694215 bayes_pls_golite062009
  • heparin binding
    		•  0.7054081997714 bayes_pls_golite062009
  • collagen binding
    		•  0.688581536921572 bayes_pls_golite062009
  • kinase binding
    		•  0.65927255037265 bayes_pls_golite062009
  • protein kinase activity
    		•  0.651225820536084 bayes_pls_golite062009
  • leukemia inhibitory factor receptor activity
    		•  0.628488391922279 bayes_pls_golite062009
  • oncostatin-M receptor activity
    		•  0.628488391922279 bayes_pls_golite062009
  • enzyme binding
    		•  0.60195860585095 bayes_pls_golite062009
  • ankyrin binding
    		•  0.56921114104552 bayes_pls_golite062009
  • identical protein binding
    		•  0.564711394496051 bayes_pls_golite062009
  • transcription factor activity
    		•  0.557290274937694 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.436168003057537 bayes_pls_golite062009
  • polysaccharide binding
    		•  0.4326581122899 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.425601964126369 bayes_pls_golite062009
  • kinase activity
    		•  0.412589450700334 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.40600177052491 bayes_pls_golite062009
  • protein kinase binding
    		•  0.405060010394646 bayes_pls_golite062009
  • structural molecule activity
    		•  0.37617823184103 bayes_pls_golite062009
  • interleukin-7 binding
    		•  0.301052531308189 bayes_pls_golite062009
  • pattern binding
    		•  0.30071837231983 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.16524109571346 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.1430595594485 bayes_pls_golite062009
  • transcription activator activity
    		•  0.135753557343301 bayes_pls_golite062009
  • actin filament binding
    		•  0.135484838710405 bayes_pls_golite062009
  • protein homodimerization activity
    		•  0.116391819218123 bayes_pls_golite062009
  • interleukin-2 receptor activity
    		•  0.115337814289139 bayes_pls_golite062009
  • integrin binding
    		•  0.0873424694168858 bayes_pls_golite062009
  • transcription factor binding
    		•  0.075900818564989 bayes_pls_golite062009
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle