YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: Cont-PA
Organism: Drosophila melanogaster
Length: 1390 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Cont-PA.

Description E-value Query
Range		 Subject
Range
Dscam-PAJ - The gene Down syndrome cell adhesion molecule is referred to in FlyBase by the symbol Dmel\Dscam (CG...
 832.0 [0..36] [1364..23]

Back

Predicted Domain #1
Region A:
Residues: [1-468] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLAKIGLLAS ILVLNLVGQI TPQFSENLPD PDPQSGQQPQ NYQPSYNKDY SPRYNPLYTG  60
   61 QQSADPNQFD NTLVDGQSPN TYKGYYDGRA GGGGLGGNVV GPGNNLGGLG PQYDPFNRNS 120
  121 IGSAGVSYRD AYTDEDNFCP EHWVSFRQTC YRFIRSPKRN WAEAKKICKA HNADLINVDN 180
  181 VEKHSFILKN LILQNQRQNR FFISARQTGP LNWVNDDNTQ LVQIEDSFSM DEQVPLENED 240
  241 LHDNRFLVQN DLNNQNINNP NQFYNSLPGT VNQRNQNNLR GFIGPNQPYG DNRYVRDRVV 300
  301 YAFSKKRDRW MFMPAYEIEL NLFICESKVL YSSDNVNIKL DDKRPYHYGL DINDMERIPR 360
  361 GPYFVKQPND TTFDVNKNRL INDVTLSCLA NGYPTPSYTW YREVYVDDRL EYQKIDPLAQ 420
  421 DRYTISGGNL IIYEPKQALD QGAYHCVAEN KFGRIRSESA HLNFGFIM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 55.045757
Match: 2v5sA
Description: No description for 2v5sA was found.

Predicted Domain #2
Region A:
Residues: [469-564] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EFNLKRSAET SEMNWGKSIF CDPPQHYPDV RYYWARDYFP NFVEEDQRVF VSRDGALYFS  60
   61 FIETVDRANY SCTVQTLVSD TGRNGPFFPL RVTPNS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 8.0
Match: 1o0vA
Description: Immunoglobulin heavy chain epsilon constant domain 2, CH2-epsilon; Immunoglobulin heavy chain epsilon constant domain 3, CH3-epsilon; Immunoglobulin heavy chain epsilon constant domain 4, CH4-epsilon
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
telethonin binding 6.64811984458494 bayes_pls_golite062009
alpha-actinin binding 5.77350124471385 bayes_pls_golite062009
actinin binding 5.69539760434923 bayes_pls_golite062009
structural constituent of muscle 4.93896503565413 bayes_pls_golite062009
binding 3.17641566810715 bayes_pls_golite062009
receptor activity 3.0754311615326 bayes_pls_golite062009
peptide antigen binding 2.94721224577771 bayes_pls_golite062009
molecular transducer activity 2.92683710723714 bayes_pls_golite062009
signal transducer activity 2.92683710723714 bayes_pls_golite062009
fibroblast growth factor 1 binding 2.81979712905308 bayes_pls_golite062009
transmembrane receptor activity 2.79758224858792 bayes_pls_golite062009
protein binding 2.22855404705168 bayes_pls_golite062009
IgG binding 1.92633562075074 bayes_pls_golite062009
olfactory receptor activity 1.79502606732682 bayes_pls_golite062009
antigen binding 1.63189745559168 bayes_pls_golite062009
cytoskeletal protein binding 1.58610597245454 bayes_pls_golite062009
actin binding 1.42681407553255 bayes_pls_golite062009
cell adhesion molecule binding 1.36789541796983 bayes_pls_golite062009
nucleic acid binding 1.32330470851159 bayes_pls_golite062009
fibroblast growth factor binding 1.27793818082552 bayes_pls_golite062009
DNA binding 1.19412627500732 bayes_pls_golite062009
transcription regulator activity 1.16252234499274 bayes_pls_golite062009
myosin light chain kinase activity 0.87238163212 bayes_pls_golite062009
actin filament binding 0.760856470721016 bayes_pls_golite062009
collagen binding 0.729893120256353 bayes_pls_golite062009
growth factor binding 0.715053526402219 bayes_pls_golite062009
receptor binding 0.632627479346393 bayes_pls_golite062009
titin binding 0.599892148302011 bayes_pls_golite062009
integrin binding 0.599569390248921 bayes_pls_golite062009
protein kinase activity 0.589015157128768 bayes_pls_golite062009
transcription factor activity 0.54549168007511 bayes_pls_golite062009
fibroblast growth factor receptor activity 0.5037774536831 bayes_pls_golite062009
myosin heavy chain binding 0.49788128784685 bayes_pls_golite062009
protein complex binding 0.43131084085213 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.300034766861208 bayes_pls_golite062009
kinase activity 0.232190923918901 bayes_pls_golite062009
cell surface binding 0.213817211551667 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.182775558017364 bayes_pls_golite062009
structural constituent of cytoskeleton 0.0579247757286607 bayes_pls_golite062009
protein serine/threonine kinase activity 0.026512949804781 bayes_pls_golite062009
structural molecule activity 0.00139730528977644 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [565-660] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NYQALIFANT FPKVFPEAPV AGDEIRLECM AFGYPIPSYN WTRQGLPLQR NAYTINYGRV  60
   61 LIIQNATTND NGEYSCTITN PRKTLMKSIY INIQMR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 79.69897
Match: 1cs6A
Description: Axonin-1
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [661-740] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PQFTIPLKDM IKDYNSDVTF ICEAFAIPDA NYTWYKNAER LDPANINRDR YIIQDNVLTI  60
   61 KFLEKDKDDA MYQCGAQNQL

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 5.56
Match: 1nctA
Description: TITIN MODULE M5, N-TERMINALLY EXTENDED, NMR
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
telethonin binding 6.38949638288343 bayes_pls_golite062009
alpha-actinin binding 5.53326178500376 bayes_pls_golite062009
actinin binding 5.48624955510658 bayes_pls_golite062009
structural constituent of muscle 4.78053264661873 bayes_pls_golite062009
binding 3.05950525762784 bayes_pls_golite062009
receptor activity 2.85791473660662 bayes_pls_golite062009
molecular transducer activity 2.78201223521838 bayes_pls_golite062009
signal transducer activity 2.78201223521838 bayes_pls_golite062009
transmembrane receptor activity 2.59488214915775 bayes_pls_golite062009
peptide antigen binding 2.59351260720134 bayes_pls_golite062009
fibroblast growth factor 1 binding 2.49355574348664 bayes_pls_golite062009
protein binding 2.15886049700791 bayes_pls_golite062009
olfactory receptor activity 1.57975990329228 bayes_pls_golite062009
IgG binding 1.57584541871373 bayes_pls_golite062009
cytoskeletal protein binding 1.54995469932689 bayes_pls_golite062009
actin binding 1.40773197641911 bayes_pls_golite062009
nucleic acid binding 1.33341865156235 bayes_pls_golite062009
cell adhesion molecule binding 1.24665876791142 bayes_pls_golite062009
DNA binding 1.20391708320115 bayes_pls_golite062009
transcription regulator activity 1.19332924581774 bayes_pls_golite062009
antigen binding 1.16861985653243 bayes_pls_golite062009
fibroblast growth factor binding 1.00587642160047 bayes_pls_golite062009
myosin light chain kinase activity 0.727812088393571 bayes_pls_golite062009
collagen binding 0.684934406852999 bayes_pls_golite062009
actin filament binding 0.684482417673051 bayes_pls_golite062009
protein kinase activity 0.605125585768526 bayes_pls_golite062009
receptor binding 0.560378932994877 bayes_pls_golite062009
transcription factor activity 0.554724181253623 bayes_pls_golite062009
growth factor binding 0.554438098743996 bayes_pls_golite062009
integrin binding 0.474366116240879 bayes_pls_golite062009
titin binding 0.395513709080215 bayes_pls_golite062009
myosin heavy chain binding 0.377234357158059 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.328985661202282 bayes_pls_golite062009
protein complex binding 0.268954327341866 bayes_pls_golite062009
kinase activity 0.268573733052192 bayes_pls_golite062009
fibroblast growth factor receptor activity 0.232191642090185 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.229394368927229 bayes_pls_golite062009
cell surface binding 0.181552455725164 bayes_pls_golite062009
protein serine/threonine kinase activity 0.0426518119496661 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [741-929] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KTSFSSAQLR VLSMKPSFKK HPLESEVYAV YNGNTTIVCD PEAAPRPKFQ WKKDGQVIGS  60
   61 GGHRRILPSG TLTISPTSRD DEGIYTCIAS NQAGTDESHA RVIVLQEIRF IETPPQRIVS 120
  121 KEHDLIFLHC EAAFDELLDI AYVWKHNGEV LKNNHDGTGR IIVDWNRLTV HNTSMRDAGD 180
  181 YECVVKSAV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 35.69897
Match: 2nziA
Description: No description for 2nziA was found.

Predicted Domain #6
Region A:
Residues: [930-1047] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NEISSKTSVS IEGAPGAPGG VQVIQISKTK AIIEWVDGSH NGRAIRYYNI LGRTNWNRTW  60
   61 VNVSTHVQAR EVDRYTSRQQ AEVVNLTPWS AYEFSVTAVN DLGIGTPSAP SPIYSTYE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.221849
Match: 1ueyA
Description: Solution Structure of The First Fibronectin Type III Domain of Human KIAA0343 protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
telethonin binding 5.81747667416248 bayes_pls_golite062009
structural constituent of muscle 5.71979489668015 bayes_pls_golite062009
alpha-actinin binding 4.57951951779666 bayes_pls_golite062009
actinin binding 4.57900103206288 bayes_pls_golite062009
transmembrane receptor activity 3.79244614134061 bayes_pls_golite062009
receptor activity 3.73567137429359 bayes_pls_golite062009
cytokine binding 3.58426984827737 bayes_pls_golite062009
molecular transducer activity 3.5100441341515 bayes_pls_golite062009
signal transducer activity 3.5100441341515 bayes_pls_golite062009
cytokine receptor activity 3.25206686803048 bayes_pls_golite062009
protein binding 3.24522318184038 bayes_pls_golite062009
binding 3.12471204223368 bayes_pls_golite062009
growth factor binding 2.4970104838834 bayes_pls_golite062009
cell adhesion molecule binding 2.32179186005318 bayes_pls_golite062009
axon guidance receptor activity 2.01367445237355 bayes_pls_golite062009
prolactin receptor activity 1.9556649101819 bayes_pls_golite062009
cytoskeletal protein binding 1.85720106085239 bayes_pls_golite062009
interleukin-2 binding 1.67132604890013 bayes_pls_golite062009
interleukin-6 binding 1.53073516901486 bayes_pls_golite062009
interleukin-6 receptor activity 1.53073516901486 bayes_pls_golite062009
nucleic acid binding 1.32813363771214 bayes_pls_golite062009
receptor binding 1.31676259534833 bayes_pls_golite062009
transcription regulator activity 1.31663344632755 bayes_pls_golite062009
peptide hormone binding 1.2420090521345 bayes_pls_golite062009
actin binding 1.21472460452555 bayes_pls_golite062009
DNA binding 1.2006039770643 bayes_pls_golite062009
myosin light chain kinase activity 1.18611050638993 bayes_pls_golite062009
glycosaminoglycan binding 0.99058387466784 bayes_pls_golite062009
protein dimerization activity 0.86564366658585 bayes_pls_golite062009
growth hormone receptor activity 0.840187286074179 bayes_pls_golite062009
cell surface binding 0.792329562040096 bayes_pls_golite062009
ciliary neurotrophic factor receptor activity 0.71036287694215 bayes_pls_golite062009
heparin binding 0.7054081997714 bayes_pls_golite062009
collagen binding 0.688581536921572 bayes_pls_golite062009
kinase binding 0.65927255037265 bayes_pls_golite062009
protein kinase activity 0.651225820536084 bayes_pls_golite062009
leukemia inhibitory factor receptor activity 0.628488391922279 bayes_pls_golite062009
oncostatin-M receptor activity 0.628488391922279 bayes_pls_golite062009
enzyme binding 0.60195860585095 bayes_pls_golite062009
ankyrin binding 0.56921114104552 bayes_pls_golite062009
identical protein binding 0.564711394496051 bayes_pls_golite062009
transcription factor activity 0.557290274937694 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.436168003057537 bayes_pls_golite062009
polysaccharide binding 0.4326581122899 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.425601964126369 bayes_pls_golite062009
kinase activity 0.412589450700334 bayes_pls_golite062009
structural constituent of cytoskeleton 0.40600177052491 bayes_pls_golite062009
protein kinase binding 0.405060010394646 bayes_pls_golite062009
structural molecule activity 0.37617823184103 bayes_pls_golite062009
interleukin-7 binding 0.301052531308189 bayes_pls_golite062009
pattern binding 0.30071837231983 bayes_pls_golite062009
protein serine/threonine kinase activity 0.16524109571346 bayes_pls_golite062009
protein heterodimerization activity 0.1430595594485 bayes_pls_golite062009
transcription activator activity 0.135753557343301 bayes_pls_golite062009
actin filament binding 0.135484838710405 bayes_pls_golite062009
protein homodimerization activity 0.116391819218123 bayes_pls_golite062009
interleukin-2 receptor activity 0.115337814289139 bayes_pls_golite062009
integrin binding 0.0873424694168858 bayes_pls_golite062009
transcription factor binding 0.075900818564989 bayes_pls_golite062009

Predicted Domain #7
Region A:
Residues: [1048-1152] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DKPYIAPRNV GGGGGKIGDL TITWDPLLPQ EQHSHGIHYK VFWKLKGAIE WASDEIKKQD  60
   61 HMGVAVVNIP LNNYYTEYEV KVQAINSVGK GPESEIAVIH SAEDM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.0
Match: 1cfbA
Description: CRYSTAL STRUCTURE OF TANDEM TYPE III FIBRONECTIN DOMAINS FROM DROSOPHILA NEUROGLIAN AT 2.0 ANGSTROMS
Matching Structure (courtesy of the PDB):

Predicted Domain #8
Region A:
Residues: [1153-1239] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PQVAPQKPIA LAYNSTCFNV TWQPIDMSRE NIRGKLIGHR LKYWKTTHQE EDSVYYLSRT  60
   61 TRNWALIVGL QPDTYYFVKV MAYNAAG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.69897
Match: 2ee2A
Description: No description for 2ee2A was found.

Predicted Domain #9
Region A:
Residues: [1240-1390] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EGPESERFEE RTYRKAPQKP PSSVHVYGIN PSTVRVVWRY VSPSQDEEPV EGYKVRIWES  60
   61 DQNMITANNT IVPIGQKLES YINNLTPGKS YNMRVLAYSN GGDGRMSSPT LHFQMGKTTR 120
  121 NGANTRHGHN INTALILSTL LLISTFLYTS Q

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.0
Match: 2edxA
Description: No description for 2edxA was found.
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle