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Protein Overview: CG10754-PA

General Information:
Name(s) found: CG10754-PA / FBpp0075676 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • This gene is referred to in FlyBase by the symbol Dmel\CG10754 (CG10754, FBgn0036314). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:12806128..12807103. It has the cytological map location 69E4. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: zinc ion binding; nucleic acid binding. There is experimental evidence that it is involved in the biological process</span>: mitotic spindle organization. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 264 amino acids

    Gene Ontology:
    Cellular Component: catalytic step 2 spliceosome [IDA]
    precatalytic spliceosome [IDA]
    spliceosomal complex [ISS]
    U2 snRNP [ISS]
    Biological Process: mitotic spindle organization [IMP]
    nuclear mRNA splicing, via spliceosome [IC][ISS]
    Molecular Function: nucleic acid binding [IEA]
    zinc ion binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDFQNRAGGK TGSGGVASWS ETNRDRKERL RQLALETIDL NKDPYFMKNH LGSYECKLCL  60
   61 TLHNNEGSYL AHTQGKKHQD NLARRAAKEA KEAPSSLLAP EKPRVEPKKF VKIGRPGYRV 120
  121 TKQRELSNGQ QSLLFQVDYP EITESIVPRH RFMSAYEQKI EPPDRKWQYL LFAAEPYETI 180
  181 GFKVPSREVE KSEGKFWTHW NRDTKQFFLQ FAFKFEPKIL PPPPPNLHRA LGPPGGFPMP 240
  241 GPPRPAMHPM FNGVHPPPPM LSNN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..139] FFAS03 2.1 Solution Structure of a Human C2H2-type Zinc Finger Protein
    2 View Details [140..264] MSA 2.030996 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  3.37529385176635 bayes_pls_golite062009
  • DNA binding
    		•  3.3049326844117 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.24981360535232 bayes_pls_golite062009
  • snRNA binding
    		•  3.16782731106334 bayes_pls_golite062009
  • RNA binding
    		•  3.11293528368816 bayes_pls_golite062009
  • U1 snRNA binding
    		•  2.86343975521155 bayes_pls_golite062009
  • binding
    		•  2.84954567129719 bayes_pls_golite062009
  • transcription factor activity
    		•  2.44389510173662 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.57041104288348 bayes_pls_golite062009
  • mRNA binding
    		•  1.28525296322454 bayes_pls_golite062009
  • transcription activator activity
    		•  1.20323819132961 bayes_pls_golite062009
  • protein binding
    		•  0.975412203442928 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.732558534458316 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.686318575498149 bayes_pls_golite062009
  • chromatin binding
    		•  0.626365497850853 bayes_pls_golite062009
  • transcription factor binding
    		•  0.515821187939278 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.380243728411498 bayes_pls_golite062009
  • catalytic activity
    		•  0.263007611601737 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.200483461579207 bayes_pls_golite062009
  • tubulin binding
    		•  0.151955152284472 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.113925660147477 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.0855506955761403 bayes_pls_golite062009
  • microtubule binding
    		•  0.05082413668213 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle