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Protein Overview: Orc4-PA

General Information:
Name(s) found: Orc4-PA / FBpp0072330 [FlyBase]
Description(s) found:
Found 24 descriptions.
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  • The gene Origin recognition complex subunit 4 is referred to in FlyBase by the symbol Dmel\Orc4 (CG2917, FBgn0023181). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:20683263..20684927. It has the cytological map location 60E1-60E2. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: DNA binding; nucleoside-triphosphatase activity; ATP binding. There is experimental evidence that it is involved in the biological process</span>: DNA replication initiation. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 459 amino acids

    Gene Ontology:
    Cellular Component: nuclear origin of replication recognition complex [IDA][ISS]
    Biological Process: DNA replication initiation [IDA][ISS]
    DNA replication [IEA]
    Molecular Function: DNA binding [IEA]
    ATP binding [IEA]
    nucleoside-triphosphatase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPEADRELVS IRRFLKERLQ RDYTTLRGYA KERSNVRLLL QRTAEMGESN SLLLLGPRGS  60
   61 GKTTLINSVL ADLLPNKSFG ENTLIVHLDG NLHTDDRVAL KSITVQMQLE NAADGKVFGS 120
  121 FAENLAFLLQ CLKAGGKHSK SVIFILEEFD LFCAHHNQTL LYNLFDVSQS AQAPICVLGV 180
  181 TCRLDVIELL EKRVKSRFSH RQVFLFPSLR RFEDYVDLCR DLLSLPTGNS LLLAAEKIYN 240
  241 LQNIQSGALY FSRNHFDPGE YGFSPRLRDA WNKQICKVLA TQQARSTLQA LHDFDISEAY 300
  301 LKNFLFRLVA HLRPQSPHIT AEKMAAVGSQ FEGDDKIELL CGLSVLELCL IIAIKHHSQI 360
  361 YDRDSFNFEI IYARFSKFAK VSTTMQAVER SIVLKAFEHL RIAELIMPLT GGAGGGVGKV 420
  421 QKEFEMHKLA LTYSQIHHCM QRYQALPTEV AQWAQSSLI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..459] PSI-BLAST 72.0 EDTA treated

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA clamp loader activity
    		•  3.22518920754305 bayes_pls_golite062009
  • protein-DNA loading ATPase activity
    		•  3.19273435123154 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  2.72462789867829 bayes_pls_golite062009
  • DNA helicase activity
    		•  2.2817164193758 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.13284212711072 bayes_pls_golite062009
  • binding
    		•  2.05253348982328 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  1.88455339138556 bayes_pls_golite062009
  • helicase activity
    		•  1.70242731830224 bayes_pls_golite062009
  • DNA replication origin binding
    		•  1.62491387774159 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.49633029954726 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • DNA-directed DNA polymerase activity
    		•  0.971476020912368 bayes_pls_golite062009
  • DNA binding
    		•  0.967303417236485 bayes_pls_golite062009
  • DNA polymerase activity
    		•  0.928091843881235 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.782430219754236 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.748437190903548 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.6071273686445 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.147579541298736 bayes_pls_golite062009
  • nucleotide binding
    		•  0.114848452385726 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.113504049290503 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.111293884322157 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.10713474095071 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.0916519414118148 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.0915913646217636 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.089234257580272 bayes_pls_golite062009
  • 3'-5' DNA helicase activity
    		•  0.0769112340058804 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle