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Protein Overview: shu-PA

General Information:
Name(s) found: shu-PA / FBpp0072146 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene shutdown is referred to in FlyBase by the symbol Dmel\shu (CG4735, FBgn0003401). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:19728984..19730802. It has the cytological map location 60A3. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: binding. There is experimental evidence that it is involved in the biological process</span>: oogenesis. 9 alleles are reported. The phenotypes of these alleles are annotated with: ovariole; nurse follicle cell; egg; oocyte; egg chamber; dorsal appendage. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 455 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDA]
    Biological Process: oogenesis [IMP]
    protein folding [IEA]
    Molecular Function: binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEENFEPYTP QLLKNPLSYS DLVKKGVEFE VDNSQQNHAR DLGLDSDSDS DYEDALDVDG  60
   61 EELRSPWTYS FDELRALMSE IDENIYKRIT RTGHVDREAV PNKARVSVRY SGYWEGETAP 120
  121 FDSSLLRGSK FVFETGQGTV VEGLEVAVRS MRPYEQAEFI ISYKLLFGEL GCPPRIKPKA 180
  181 DALFKVEVID YSLIGDAKGI DAIPQEDRDK FCVVYPKAVD LHLHGKDSVK LGRYQSAATA 240
  241 FERAVSSLNY CRMANDEEER KQTELLTTLN QNLMIVYNKM NKPKRACIMM KALRHLTMGN 300
  301 PSCKALFQEG RALAALGEYN LARNAYLQAQ AKQPANKEIS DEIISMNKRI SKYEEASRDI 360
  361 WARAFSLKNS KSDVRKTPAQ LEKEAKEQDF NDKMEDLIRR FKNTSDQQVS FSRKSYSNAQ 420
  421 FDATCKLAKE HNLKLTLSPI QEDVLTLSKP DVKFA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..455] PSI-BLAST 50.154902 FKBP51, C-terminal domain; FKBP51, N-terminal domains

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • procollagen-proline 4-dioxygenase activity
    		•  6.80616214194201 bayes_pls_golite062009
  • peptidyl-proline 4-dioxygenase activity
    		•  6.80616214194201 bayes_pls_golite062009
  • peptidyl-proline dioxygenase activity
    		•  6.80616214194201 bayes_pls_golite062009
  • procollagen-proline dioxygenase activity
    		•  6.80616214194201 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
    		•  4.77770372249654 bayes_pls_golite062009
  • peptidyl-prolyl cis-trans isomerase activity
    		•  4.0615867467963 bayes_pls_golite062009
  • cis-trans isomerase activity
    		•  3.99265212272703 bayes_pls_golite062009
  • macrolide binding
    		•  2.8097578502972 bayes_pls_golite062009
  • FK506 binding
    		•  2.69770241359364 bayes_pls_golite062009
  • isomerase activity
    		•  2.31710030777753 bayes_pls_golite062009
  • heat shock protein binding
    		•  1.35268080101836 bayes_pls_golite062009
  • catalytic activity
    		•  0.885282592863018 bayes_pls_golite062009
  • ryanodine-sensitive calcium-release channel activity
    		•  0.753553267055211 bayes_pls_golite062009
  • intracellular ligand-gated calcium channel activity
    		•  0.753553267055211 bayes_pls_golite062009
  • binding
    		•  0.609533374908001 bayes_pls_golite062009
  • drug binding
    		•  0.386165046836496 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.327099943267853 bayes_pls_golite062009
  • transferase activity
    		•  0.31967318602798 bayes_pls_golite062009
  • kinase activity
    		•  0.301313235341922 bayes_pls_golite062009
  • unfolded protein binding
    		•  0.27473817613726 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.225873481281805 bayes_pls_golite062009
  • protein binding
    		•  0.021021468760355 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle