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Protein Overview: FBpp0303033, Pcl-PA

General Information:
Name(s) found: FBpp0303033 [FlyBase]
Pcl-PA / FBpp0085914 [FlyBase]
Description(s) found:
Found 29 descriptions.
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  • type=protein; loc=2R:join(14023429..14024916,14024976..14025148,14025204..14026278,14026346..14026741); ID=FBpp0303033; name=Pcl-PB; parent=FBgn0003044,FBtr0329998; dbxref=FlyBase:FBpp0303033,FlyBase_Annotation_IDs:CG5109-PB,REFSEQ:NP_001261067,GB_protein:AGB93599; MD5=b9abc288909cd63426325574b9ba04f8; length=1043; release=r5.56; species=Dmel; [FlyBase]
  • The gene Polycomblike is referred to in FlyBase by the symbol Dmel\Pcl (CG5109, FBgn0003044). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:14022934..14026947. It has the cytological map location 55B8. There is experimental evidence that it has the molecular function</span>: transcription factor activity; protein binding; DNA binding. There is experimental evidence that it is involved in the biological process</span>: chromatin modification; negative regulation of transcription, DNA-dependent. 37 alleles are reported. The phenotypes of these alleles are annotated with 33 unique terms, many of which group under: adult segment; embryonic abdomen; organ system; embryonic segment; larval abdominal segment; embryonic tagma; abdominal segment 7; adult; adult mesothoracic segment; thoracic segment. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1043 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA][ISS][NAS]
    Biological Process: chromatin modification [IDA]
    negative regulation of transcription, DNA-dependent [IDA]
    Molecular Function: DNA binding [IDA]
    transcription factor activity [IDA]
    zinc ion binding [IEA]
    protein binding [IPI]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMNNHFHLQH DHPPQNVAHP FMQQPSTAVP SAPPATYGYL AQPAGQQPQW MTTTYQILPP  60
   61 SVGPATVAKR YYATTGPQTT HPTHPSTIQI TNSFAQQSTP PKQQAATSCS PFKANNIRII 120
  121 STAPSVYSLN KPPQEAHSTY APVQSYYLPS GGGQTAGQIN LLAASGTGKQ LQPPPLVPVT 180
  181 NSTSPPSTVV LDRINICINN HYTETPTSLS SSLTTAQQPS PIIPAIQHKA ILPLIDSSTA 240
  241 DSSSCSSSSV SSSSYSGTAT TSAAVVIVDE PDSTTTTPQT PPTTPEAMSS PGKSSPSPPL 300
  301 LATQSLLKGV NSMKPSFKTV EAAPPTPPTP PSPPPPPPAP PVAAPSPAVT YALQEDVFIK 360
  361 CNDGRFYLGT IIDQTSDQYL IRFDDQSEQW CEPDKLRKLG GGSSITAGGG GASTTESTNT 420
  421 SPSGPMCVAC KRSDIEDVVE ICERCGRGYH RGCTVEIVTG SGIWSCKRCA KPMKMQQPVS 480
  481 HKITKPAGIC RQLPYHADKL SWDEKHRVNE EQIYCYCGKP GKFDHNMLQC CKCRNWFHTQ 540
  541 CMQNFKKKLL RGDMFFVFCC TVCNNGIEFV RRMQIEWVDV LHIALYNLRK HQHQKYHHLL 600
  601 NDIWPFILEQ RHQLPICEKW RTLPETALME RLKQTLKDYS DRFVCGREFK RAPAFYALRH 660
  661 SGPPHIPKVF LEPHEELSDE LLEKRFKLML MPEEPDEGAN ELPKRVPKDV YEFNTDEDDP 720
  721 VETSEDEIPI KQIIEKAKKQ AAQKADKHDE LPLKPDLADD NANDGDPGKL PAPIPPLLDA 780
  781 NSSRKRKAFR LSKRYDNSRN HCDLSSDENS SSSRGTSSLD LIIPPPVNFL GRNNPFLMAT 840
  841 PKKASQGRSI SVGTGVGVNG IINSIFKLKG TSKEQPRMVR TIKRRLSAKD ITIGPNQEVR 900
  901 RRRTRRLTTA IEVISTTTIN PIPSHYLPIY AKDLQPPAPP MGKPTHGRLL RQRPQKQSPS 960
  961 QSRRNSTSST ATSSSSNGIG APGHSMLDLK QSVNKYFGGA MNRIDAGEPF AIRAKRRMGN1020
 1021 GQVQYLVEWG GDTATTAIGL LGN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..107] MSA 3.245997 View MSA. No confident structure predictions are available.
    2 View Details [108..178] deduced N/A No confident structure predictions are available.
    3 View Details [179..329] MSA 3.253981 View MSA. No confident structure predictions are available.
    4 View Details [330..483] PSI-BLAST 7.0 No description for 2ysmA was found.
    5 View Details [484..581] FFAS03 2.48 Solution structure of PHD domain in PHF8
    6 View Details [582..670] deduced N/A No confident structure predictions are available.
    7 View Details [671..853] deduced N/A No confident structure predictions are available.
    8 View Details [854..1043] MSA 1.012981 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • transcription regulator activity
    		•  2.84543733401722 bayes_pls_golite062009
  • binding
    		•  2.84147289283175 bayes_pls_golite062009
  • histone binding
    		•  2.70040054044692 bayes_pls_golite062009
  • DNA binding
    		•  2.61461572393763 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.59290953932215 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.05685078783854 bayes_pls_golite062009
  • transcription factor activity
    		•  1.59046392323038 bayes_pls_golite062009
  • methylated histone residue binding
    		•  1.34633512809029 bayes_pls_golite062009
  • protein binding
    		•  1.32925779020231 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  0.840604267149776 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  0.840604267149776 bayes_pls_golite062009
  • transcription activator activity
    		•  0.663225694514289 bayes_pls_golite062009
  • chromatin binding
    		•  0.238939737856273 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.0471610688739243 bayes_pls_golite062009
  • transcription factor binding
    		•  0.0293954104210474 bayes_pls_golite062009
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle