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Protein Overview: Strn-Mlck-PF

General Information:
Name(s) found: Strn-Mlck-PF / FBpp0086412 [FlyBase]
Description(s) found:
Found 13 descriptions.
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  • The gene Stretchin-Mlck is referred to in FlyBase by the symbol Dmel\Strn-Mlck (CG18255, FBgn0013988). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:11834431..11873458. It has the cytological map location 52D4-52D9. There is experimental evidence that it has the molecular function</span>: myosin light chain kinase activity; calmodulin-dependent protein kinase activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: protein amino acid phosphorylation. 12 alleles are reported. No phenotypic data is available. It has 13 annotated transcripts and 13 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1506 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: protein amino acid phosphorylation [IEA][ISS][NAS]
    Molecular Function: ATP binding [IEA]
    calmodulin-dependent protein kinase activity [IDA]
    structural constituent of cytoskeleton [ISS]
    protein serine/threonine kinase activity [NAS]
    myosin light chain kinase activity [IDA][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHNIFFSIDI LNKSRMDKVH TRHGNIETLP RFVRNLRNLR CCDGDAISLE CHVEADPEPF  60
   61 IIWEKDGHVM PSDRDYVMSF DGTKATLSIP RVYPEDEGEY TCVAKNSVGR SLSSACIIVD 120
  121 VPEEKENMLS RQLARPSGLL SAHSTPRSTP RSTPARSFSP LRLSYRTSSI DLSGVAERRR 180
  181 SDARNAITAP KFLAIPYNRV VEEGDSVRFQ CAISGHPTPW ATWDKDGLIV TPTPRIAVKE 240
  241 IDDLRIIEID EVTFDDAGLY RVTLENDFGR IEATARLDVI RSSRYSKSPS VRSVRASSSR 300
  301 RNAHLYRRIM GPSTAIGGRM ALASGYRGSS VPSVRFYHND VELEASERVH ILLQDSMALL 360
  361 IVDNVTREDE GQYTCIISGD HDPLITSTTV TFHDSNTEIR RRRAVITERL PEITKSLEGE 420
  421 VIDLCCSIEC DEPYSYVWLR NGEILPDSDE FNYIDHGNGR LCLRINDAFD IDSGIYSCQV 480
  481 FTSDINDSTS DSTFDSHSIC SLINSGCSDC SSSGELCVLE RDLRGQDEEC VQLLKTPLPV 540
  541 VCASGDEALF YARVFPCDAE ADWYLNGQLL AQADDSLNMT LESYPENGIR LLRMRDVTAS 600
  601 RSGEICLQVK HPQAEFRRIP TTRTYTSLLV LPAIRGNSSS SSLAARSCIL TRPEDCTALI 660
  661 GGHVRLSVRY EPFPGTKVIW YKACHPIVES SNVTIRTTSQ QSTLYITDIS ADDSGKYTVE 720
  721 VMNDYGVEAA AASVAVEGPP EPPSGQPSVS LGPDRVAVAW CGPPYDGGCM ITGFIIEMQT 780
  781 IGDENCDEDS WQQVTRVVDS LAYTVKNLQP ERQYRFRVRA ENIHGRSAPG QASELVQITN 840
  841 TPQRSTSSDA SDRFGQATVS VQSGGDFKSR FEIIEELGKG RFGIVYKVQE RGQPEQLLAA 900
  901 KVIKCIKSQD RQKVLEEISI MRALQHPKLL QLAASFESPR EIVMVMEYIT GGELFERVVA 960
  961 DDFTLTEMDC ILFLRQVCDG VAYMHGQSVV HLDLKPENIM CHTRTSHQIK IIDFGLAQRL1020
 1021 DTKAPVRVLF GTPEFIPPEI ISYEPIGFQS DMWSVGVICY VLLSGLSPFM GDTDVETFSN1080
 1081 ITRADYDYDD EAFDCVSQEA KDFISQLLVH RKEDRLTAQQ CLASKWLSQR PDDSLSNNKI1140
 1141 CTDKLKKFII RRKWQKTGNA IRALGRMANL SVSRRNSAIA MGVLSSPRPS ISGLGMLTTS1200
 1201 AIGSGTSSQM TSLHEEEDDF SGEMPPVEKR TVLKLRDKSQ CSERSDSGYS ECSNCSGAQE1260
 1261 TLLLSLAKSK LEAIAKASTL PTVVHDTEQP VSLELPTKGE AIMRSDFTNT IKMRKKSLED1320
 1321 SAAREKPRSK PQVKPLLCES KLKVSQLKDR FQVSPAPASA SASASAANKP PLAYGPFKIA1380
 1381 KVASVGRISR TEEPGRSGRG APSVSGKGKS PQVRSMPSSP LPQRSATPTR LMSQRVREAA1440
 1441 ERLAQQHTVA SAQRHLGNGR GTGTGNGNGN SNSNGNGNGN TAETNRESRA RRLINRFNSE1500
 1501 TQHITS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..724] PSI-BLAST 54.0 Model of human carcinoembryonic antigen by homology modelling and curve-fitting to experimental solution scattering data
    2 View Details [725..1129] PSI-BLAST 34.39794 CHICKEN SRC TYROSINE KINASE
    3 View Details [1130..1265] PSI-BLAST 46.045757 TWITCHIN KINASE FRAGMENT (C.ELEGANS), AUTOREGULATED PROTEIN KINASE AND IMMUNOGLOBULIN DOMAINS
    4 View Details [1266..1506] MSA 1.321997 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • calmodulin-dependent protein kinase activity
    		•  4.31938467136214 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • tubulin binding
    		•  2.18641675163967 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.12615078788254 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • microtubule binding
    		•  1.88110801192607 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.56748951434625 bayes_pls_golite062009
  • phosphoinositide 3-kinase activity
    		•  1.5013287968167 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.46547714006072 bayes_pls_golite062009
  • 1-phosphatidylinositol-3-kinase activity
    		•  1.43713739644553 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.3898059094397 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.38496328649031 bayes_pls_golite062009
  • DNA binding
    		•  1.35333135345112 bayes_pls_golite062009
  • molecular adaptor activity
    		•  1.33740973673697 bayes_pls_golite062009
  • actin binding
    		•  1.33479685165255 bayes_pls_golite062009
  • gamma-tubulin binding
    		•  1.28511591054866 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.27291233344322 bayes_pls_golite062009
  • SH3/SH2 adaptor activity
    		•  1.2323381312171 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • transcription factor activity
    		•  1.10928254946881 bayes_pls_golite062009
  • transcription activator activity
    		•  0.997272622653026 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.925299895386908 bayes_pls_golite062009
  • protein binding, bridging
    		•  0.83823250804321 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.612883428421652 bayes_pls_golite062009
  • transporter activity
    		•  0.553953601841147 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.499492353295369 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • protein phosphorylated amino acid binding
    		•  0.43808715710519 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.401250804041384 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.37676337669549 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.35402045013148 bayes_pls_golite062009
  • signal transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • actin filament binding
    		•  0.2403700250846 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.08504542461349 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.0611721261859464 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.0556163711947139 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.00652065412910241 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle