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Protein Overview: FBpp0303577, FBp...

General Information:
Name(s) found: FBpp0303577 [FlyBase]
FBpp0303575 [FlyBase]
Description(s) found:
Found 32 descriptions.
SHOW ALL
  • type=protein; loc=2R:complement(11760884..11760970,11761040..11761182,11761795..11761954,11762017..11763541,11763606..11763749,11764536..11764607,11764677..11765045,11766566..11766637,11766901..11767119,11767204..11767357,11767427..11767584,11768872..11769087,11770074..11770217,11770299..11770440,11771840..11772075,11772850..11772993,11773090..11773161,11773604..11773675,11773749..11773820,11777795..11778108); ID=FBpp0303577; name=sli-PE; parent=FBgn0264089,FBtr0330733; dbxref=FlyBase_Annotation_IDs:CG43758-PE,FlyBase:FBpp0303577,REFSEQ:NP_001097334,GB_protein:ABV53817; MD5=73dbba4196d3a798bdaa4a1b35b44663; length=1504; release=r5.56; species=Dmel; [FlyBase]
  • type=protein; loc=2R:complement(11760884..11760970,11761040..11761182,11761795..11761954,11762017..11763541,11763606..11763749,11764536..11764607,11764677..11765045,11766566..11766637,11766901..11767119,11767204..11767357,11767427..11767584,11768872..11769087,11770074..11770217,11770299..11770440,11771840..11772075,11772850..11772993,11773090..11773161,11773604..11773675,11773749..11773820,11777795..11778108); ID=FBpp0303575; name=sli-PC; parent=FBgn0264089,FBtr0330731; dbxref=FlyBase_Annotation_IDs:CG43758-PC,FlyBase:FBpp0303575,REFSEQ:NP_476727,GB_protein:AAF58097; MD5=73dbba4196d3a798bdaa4a1b35b44663; length=1504; release=r5.56; species=Dmel; [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1504 amino acids

    Gene Ontology:
    Cellular Component: extracellular region [IDA]
    proteinaceous extracellular matrix [TAS]
    Biological Process: negative chemotaxis [IMP]
    epithelial cell migration, open tracheal system [IMP]
    neuron migration [IMP]
    neuron differentiation [IMP]
    mesoderm migration [IMP]
    positive regulation of cell-cell adhesion [IMP]
    salivary gland boundary specification [IMP]
    axon guidance [IGI][IMP][IPI]
    axon midline choice point recognition [IMP]
    embryonic heart tube development [IMP]
    glial cell migration [IMP]
    Molecular Function: protein binding [IPI]
    calcium ion binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAPSRTTLM PPPFRLQLRL LILPILLLLR HDAVHAEPYS GGFGSSAVSS GGLGSVGIHI  60
   61 PGGGVGVITE ARCPRVCSCT GLNVDCSHRG LTSVPRKISA DVERLELQGN NLTVIYETDF 120
  121 QRLTKLRMLQ LTDNQIHTIE RNSFQDLVSL ERLRLNNNRL KAIPENFVTS SASLLRLDIS 180
  181 NNVITTVGRR VFKGAQSLRS LQLDNNQITC LDEHAFKGLV ELEILTLNNN NLTSLPHNIF 240
  241 GGLGRLRALR LSDNPFACDC HLSWLSRFLR SATRLAPYTR CQSPSQLKGQ NVADLHDQEF 300
  301 KCSGLTEHAP MECGAENSCP HPCRCADGIV DCREKSLTSV PVTLPDDTTE LRLEQNFITE 360
  361 LPPKSFSSFR RLRRIDLSNN NISRIAHDAL SGLKQLTTLV LYGNKIKDLP SGVFKGLGSL 420
  421 QLLLLNANEI SCIRKDAFRD LHSLSLLSLY DNNIQSLANG TFDAMKSIKT VHLAKNPFIC 480
  481 DCNLRWLADY LHKNPIETSG ARCESPKRMH RRRIESLREE KFKCSWDELR MKLSGECRMD 540
  541 SDCPAMCHCE GTTVDCTGRG LKEIPRDIPL HTTELLLNDN ELGRISSDGL FGRLPHLVKL 600
  601 ELKRNQLTGI EPNAFEGASH IQELQLGENK IKEISNKMFL GLHQLKTLNL YDNQISCVMP 660
  661 GSFEHLNSLT SLNLASNPFN CNCHLAWFAE WLRKKSLNGG AARCGAPSKV RDVQIKDLPH 720
  721 SEFKCSSENS EGCLGDGYCP PSCTCTGTVV RCSRNQLKEI PRGIPAETSE LYLESNEIEQ 780
  781 IHYERIRHLR SLTRLDLSNN QITILSNYTF ANLTKLSTLI ISYNKLQCLQ RHALSGLNNL 840
  841 RVLSLHGNRI SMLPEGSFED LKSLTHIALG SNPLYCDCGL KWFSDWIKLD YVEPGIARCA 900
  901 EPEQMKDKLI LSTPSSSFVC RGRVRNDILA KCNACFEQPC QNQAQCVALP QREYQCLCQP 960
  961 GYHGKHCEFM IDACYGNPCR NNATCTVLEE GRFSCQCAPG YTGARCETNI DDCLGEIKCQ1020
 1021 NNATCIDGVE SYKCECQPGF SGEFCDTKIQ FCSPEFNPCA NGAKCMDHFT HYSCDCQAGF1080
 1081 HGTNCTDNID DCQNHMCQNG GTCVDGINDY QCRCPDDYTG KYCEGHNMIS MMYPQTSPCQ1140
 1141 NHECKHGVCF QPNAQGSDYL CRCHPGYTGK WCEYLTSISF VHNNSFVELE PLRTRPEANV1200
 1201 TIVFSSAEQN GILMYDGQDA HLAVELFNGR IRVSYDVGNH PVSTMYSFEM VADGKYHAVE1260
 1261 LLAIKKNFTL RVDRGLARSI INEGSNDYLK LTTPMFLGGL PVDPAQQAYK NWQIRNLTSF1320
 1321 KGCMKEVWIN HKLVDFGNAQ RQQKITPGCA LLEGEQQEEE DDEQDFMDET PHIKEEPVDP1380
 1381 CLENKCRRGS RCVPNSNARD GYQCKCKHGQ RGRYCDQGEG STEPPTVTAA STCRKEQVRE1440
 1441 YYTENDCRSR QPLKYAKCVG GCGNQCCAAK IVRRRKVRMV CSNNRKYIKN LDIVRKCGCT1500
 1501 KKCY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..132] PSI-BLAST 31.154902 No description for 2v70A was found.
    2 View Details [133..414] PSI-BLAST 8.522879 Ribonuclease inhibitor
    3 View Details [415..524] PSI-BLAST 35.154902 No description for 2v9sA was found.
    4 View Details [525..747] PSI-BLAST 26.39794 Third LRR domain of Drosophila Slit
    5 View Details [748..822] FFAS03 4.34 No description for 2o6rA was found.
    6 View Details [823..1018] PSI-BLAST 3.09691 No description for 2dtgE was found.
    7 View Details [1019..1079] PSI-BLAST 10.69897 No description for 2gy5A was found.
    8 View Details [1080..1179] PSI-BLAST 13.221849 NMR structure of the human NOTCH-1 ligand binding region
    9 View Details [1180..1376] FFAS03 5.77 Modulation of agrin function by alternative splicing and Ca2+ binding
    10 View Details [1377..1504] PSI-BLAST 4.221849 Coagulation factor VIIa

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • cytoskeletal protein binding
    		•  2.84127269195072 bayes_pls_golite062009
  • binding
    		•  2.665591019824 bayes_pls_golite062009
  • protein binding
    		•  2.66138763326419 bayes_pls_golite062009
  • actin binding
    		•  1.83229753790722 bayes_pls_golite062009
  • tropomyosin binding
    		•  1.57286076317127 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.224746789416101 bayes_pls_golite062009
  • catalytic activity
    		•  0.143741655309638 bayes_pls_golite062009
    3 No functions predicted.
    4
    Term Confidence Notes
  • extracellular matrix structural constituent
    		•  4.44612590443184 bayes_pls_golite062009
  • receptor activity
    		•  3.83269261081332 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  3.75945815830294 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  3.09281229196379 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.99319600166105 bayes_pls_golite062009
  • signal transducer activity
    		•  2.99319600166105 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  2.52105909753656 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.98576551585076 bayes_pls_golite062009
  • binding
    		•  1.87302803330255 bayes_pls_golite062009
  • polysaccharide binding
    		•  1.84025331724573 bayes_pls_golite062009
  • protein binding
    		•  1.69661396118522 bayes_pls_golite062009
  • receptor binding
    		•  1.38917750110812 bayes_pls_golite062009
  • heparin binding
    		•  1.04092853418001 bayes_pls_golite062009
  • extracellular matrix binding
    		•  0.907118880836251 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.6470432578516 bayes_pls_golite062009
  • growth factor binding
    		•  0.431661995245312 bayes_pls_golite062009
  • protein-hormone receptor activity
    		•  0.42902267001067 bayes_pls_golite062009
  • protein kinase activity
    		•  0.34410822799842 bayes_pls_golite062009
  • pattern binding
    		•  0.339536765321749 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  0.120223037701308 bayes_pls_golite062009
  • collagen binding
    		•  0.085405748322021 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.0636301103723942 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  0.0622531178657224 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.0218224916407005 bayes_pls_golite062009
    5 No functions predicted.
    6
    Term Confidence Notes
  • insulin-like growth factor I binding
    		•  8.69006363035763 bayes_pls_golite062009
  • growth factor binding
    		•  5.65509536971267 bayes_pls_golite062009
  • protein tyrosine phosphatase activator activity
    		•  4.80554848605653 bayes_pls_golite062009
  • insulin-like growth factor binding
    		•  4.45140135017342 bayes_pls_golite062009
  • phosphatase activator activity
    		•  4.31085344777978 bayes_pls_golite062009
  • binding
    		•  3.10942625145915 bayes_pls_golite062009
  • protein binding
    		•  3.04595153576805 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.11274485218746 bayes_pls_golite062009
  • receptor activity
    		•  2.04770371945982 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.716940423168 bayes_pls_golite062009
  • signal transducer activity
    		•  1.716940423168 bayes_pls_golite062009
  • insulin-like growth factor II binding
    		•  1.39804733127147 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.621654050156711 bayes_pls_golite062009
  • protein kinase activity
    		•  0.550952980954245 bayes_pls_golite062009
  • glycoprotein binding
    		•  0.41080910982871 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.280642269223917 bayes_pls_golite062009
  • catalytic activity
    		•  0.271811389148807 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.254237892990218 bayes_pls_golite062009
  • kinase activity
    		•  0.221196251839524 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  0.134487277843761 bayes_pls_golite062009
  • enzyme activator activity
    		•  0.126307392530805 bayes_pls_golite062009
  • protein phosphatase binding
    		•  0.00944124612709007 bayes_pls_golite062009
    7 No functions predicted.
    8 No functions predicted.
    9
    Term Confidence Notes
  • extracellular matrix structural constituent
    		•  4.9587779362039 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  2.52684550673329 bayes_pls_golite062009
  • fibronectin binding
    		•  2.46930149922943 bayes_pls_golite062009
  • binding
    		•  2.36160381896665 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.17920418295591 bayes_pls_golite062009
  • polysaccharide binding
    		•  2.16789652353076 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.9830722589036 bayes_pls_golite062009
  • DNA binding
    		•  1.82525586215701 bayes_pls_golite062009
  • protein binding
    		•  1.78031360242224 bayes_pls_golite062009
  • receptor activity
    		•  1.77396325197931 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.72892726774108 bayes_pls_golite062009
  • signal transducer activity
    		•  1.69219314980524 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.69219314980524 bayes_pls_golite062009
  • carbohydrate binding
    		•  1.60205275599272 bayes_pls_golite062009
  • heparin binding
    		•  1.48860421410709 bayes_pls_golite062009
  • transcription activator activity
    		•  1.26968013346197 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.26658862258675 bayes_pls_golite062009
  • transporter activity
    		•  1.25957423734038 bayes_pls_golite062009
  • transcription factor activity
    		•  1.16784442642933 bayes_pls_golite062009
  • extracellular matrix binding
    		•  1.1514513943243 bayes_pls_golite062009
  • sugar binding
    		•  1.14124441774262 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.04270043888428 bayes_pls_golite062009
  • receptor binding
    		•  0.909114404082345 bayes_pls_golite062009
  • growth factor activity
    		•  0.848003781759354 bayes_pls_golite062009
  • growth factor binding
    		•  0.810577516483879 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.778809723141833 bayes_pls_golite062009
  • pattern binding
    		•  0.666119751267046 bayes_pls_golite062009
  • cytokine binding
    		•  0.646928714072463 bayes_pls_golite062009
  • monosaccharide binding
    		•  0.624657026252492 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.526287085745855 bayes_pls_golite062009
  • protein kinase activity
    		•  0.358328289529296 bayes_pls_golite062009
  • zymosan binding
    		•  0.325250916876747 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.155087758481234 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.130242121480916 bayes_pls_golite062009
  • kinase activity
    		•  0.0933699760742077 bayes_pls_golite062009
    10 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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