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View Structure Prediction Details

Protein: FBpp0303577, FBp...
Organism: Drosophila melanogaster
Length: 1504 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FBpp0303577, FBp....

Description E-value Query
Range		 Subject
Range
gi|4590406 - gi|4590406|gb|AAD26567.1|AF126540_1 slit protein [Drosophila melanogaster]
 821.0 [0..1] [1504..1]

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Predicted Domain #1
Region A:
Residues: [1-132] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAPSRTTLM PPPFRLQLRL LILPILLLLR HDAVHAEPYS GGFGSSAVSS GGLGSVGIHI  60
   61 PGGGVGVITE ARCPRVCSCT GLNVDCSHRG LTSVPRKISA DVERLELQGN NLTVIYETDF 120
  121 QRLTKLRMLQ LT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 31.154902
Match: 2v70A
Description: No description for 2v70A was found.

Predicted Domain #2
Region A:
Residues: [133-414] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DNQIHTIERN SFQDLVSLER LRLNNNRLKA IPENFVTSSA SLLRLDISNN VITTVGRRVF  60
   61 KGAQSLRSLQ LDNNQITCLD EHAFKGLVEL EILTLNNNNL TSLPHNIFGG LGRLRALRLS 120
  121 DNPFACDCHL SWLSRFLRSA TRLAPYTRCQ SPSQLKGQNV ADLHDQEFKC SGLTEHAPME 180
  181 CGAENSCPHP CRCADGIVDC REKSLTSVPV TLPDDTTELR LEQNFITELP PKSFSSFRRL 240
  241 RRIDLSNNNI SRIAHDALSG LKQLTTLVLY GNKIKDLPSG VF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 8.522879
Match: 1dfjI
Description: Ribonuclease inhibitor
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cytoskeletal protein binding 2.84127269195072 bayes_pls_golite062009
binding 2.665591019824 bayes_pls_golite062009
protein binding 2.66138763326419 bayes_pls_golite062009
actin binding 1.83229753790722 bayes_pls_golite062009
tropomyosin binding 1.57286076317127 bayes_pls_golite062009
enzyme regulator activity 0.224746789416101 bayes_pls_golite062009
catalytic activity 0.143741655309638 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [415-524] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KGLGSLQLLL LNANEISCIR KDAFRDLHSL SLLSLYDNNI QSLANGTFDA MKSIKTVHLA  60
   61 KNPFICDCNL RWLADYLHKN PIETSGARCE SPKRMHRRRI ESLREEKFKC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 35.154902
Match: 2v9sA
Description: No description for 2v9sA was found.

Predicted Domain #4
Region A:
Residues: [525-747] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SWDELRMKLS GECRMDSDCP AMCHCEGTTV DCTGRGLKEI PRDIPLHTTE LLLNDNELGR  60
   61 ISSDGLFGRL PHLVKLELKR NQLTGIEPNA FEGASHIQEL QLGENKIKEI SNKMFLGLHQ 120
  121 LKTLNLYDNQ ISCVMPGSFE HLNSLTSLNL ASNPFNCNCH LAWFAEWLRK KSLNGGAARC 180
  181 GAPSKVRDVQ IKDLPHSEFK CSSENSEGCL GDGYCPPSCT CTG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 26.39794
Match: 1w8aA
Description: Third LRR domain of Drosophila Slit
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
extracellular matrix structural constituent 4.44612590443184 bayes_pls_golite062009
receptor activity 3.83269261081332 bayes_pls_golite062009
transmembrane receptor activity 3.75945815830294 bayes_pls_golite062009
G-protein coupled receptor activity 3.09281229196379 bayes_pls_golite062009
molecular transducer activity 2.99319600166105 bayes_pls_golite062009
signal transducer activity 2.99319600166105 bayes_pls_golite062009
glycosaminoglycan binding 2.52105909753656 bayes_pls_golite062009
nucleic acid binding 1.98576551585076 bayes_pls_golite062009
binding 1.87302803330255 bayes_pls_golite062009
polysaccharide binding 1.84025331724573 bayes_pls_golite062009
protein binding 1.69661396118522 bayes_pls_golite062009
receptor binding 1.38917750110812 bayes_pls_golite062009
heparin binding 1.04092853418001 bayes_pls_golite062009
extracellular matrix binding 0.907118880836251 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.6470432578516 bayes_pls_golite062009
growth factor binding 0.431661995245312 bayes_pls_golite062009
protein-hormone receptor activity 0.42902267001067 bayes_pls_golite062009
protein kinase activity 0.34410822799842 bayes_pls_golite062009
pattern binding 0.339536765321749 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 0.120223037701308 bayes_pls_golite062009
collagen binding 0.085405748322021 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.0636301103723942 bayes_pls_golite062009
receptor signaling protein activity 0.0622531178657224 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.0218224916407005 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [748-822] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TVVRCSRNQL KEIPRGIPAE TSELYLESNE IEQIHYERIR HLRSLTRLDL SNNQITILSN  60
   61 YTFANLTKLS TLIIS

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.34
Match: 2o6rA
Description: No description for 2o6rA was found.

Predicted Domain #6
Region A:
Residues: [823-1018] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YNKLQCLQRH ALSGLNNLRV LSLHGNRISM LPEGSFEDLK SLTHIALGSN PLYCDCGLKW  60
   61 FSDWIKLDYV EPGIARCAEP EQMKDKLILS TPSSSFVCRG RVRNDILAKC NACFEQPCQN 120
  121 QAQCVALPQR EYQCLCQPGY HGKHCEFMID ACYGNPCRNN ATCTVLEEGR FSCQCAPGYT 180
  181 GARCETNIDD CLGEIK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.09691
Match: 2dtgE
Description: No description for 2dtgE was found.

Predicted functions:

Term Confidence Notes
insulin-like growth factor I binding 8.69006363035763 bayes_pls_golite062009
growth factor binding 5.65509536971267 bayes_pls_golite062009
protein tyrosine phosphatase activator activity 4.80554848605653 bayes_pls_golite062009
insulin-like growth factor binding 4.45140135017342 bayes_pls_golite062009
phosphatase activator activity 4.31085344777978 bayes_pls_golite062009
binding 3.10942625145915 bayes_pls_golite062009
protein binding 3.04595153576805 bayes_pls_golite062009
transmembrane receptor activity 2.11274485218746 bayes_pls_golite062009
receptor activity 2.04770371945982 bayes_pls_golite062009
molecular transducer activity 1.716940423168 bayes_pls_golite062009
signal transducer activity 1.716940423168 bayes_pls_golite062009
insulin-like growth factor II binding 1.39804733127147 bayes_pls_golite062009
enzyme regulator activity 0.621654050156711 bayes_pls_golite062009
protein kinase activity 0.550952980954245 bayes_pls_golite062009
glycoprotein binding 0.41080910982871 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.280642269223917 bayes_pls_golite062009
catalytic activity 0.271811389148807 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.254237892990218 bayes_pls_golite062009
kinase activity 0.221196251839524 bayes_pls_golite062009
protein tyrosine kinase activity 0.134487277843761 bayes_pls_golite062009
enzyme activator activity 0.126307392530805 bayes_pls_golite062009
protein phosphatase binding 0.00944124612709007 bayes_pls_golite062009

Predicted Domain #7
Region A:
Residues: [1019-1079] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CQNNATCIDG VESYKCECQP GFSGEFCDTK IQFCSPEFNP CANGAKCMDH FTHYSCDCQA  60
   61 G

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.69897
Match: 2gy5A
Description: No description for 2gy5A was found.

Predicted Domain #8
Region A:
Residues: [1080-1179] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FHGTNCTDNI DDCQNHMCQN GGTCVDGIND YQCRCPDDYT GKYCEGHNMI SMMYPQTSPC  60
   61 QNHECKHGVC FQPNAQGSDY LCRCHPGYTG KWCEYLTSIS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.221849
Match: 1tozA
Description: NMR structure of the human NOTCH-1 ligand binding region
Matching Structure (courtesy of the PDB):

Predicted Domain #9
Region A:
Residues: [1180-1376] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FVHNNSFVEL EPLRTRPEAN VTIVFSSAEQ NGILMYDGQD AHLAVELFNG RIRVSYDVGN  60
   61 HPVSTMYSFE MVADGKYHAV ELLAIKKNFT LRVDRGLARS IINEGSNDYL KLTTPMFLGG 120
  121 LPVDPAQQAY KNWQIRNLTS FKGCMKEVWI NHKLVDFGNA QRQQKITPGC ALLEGEQQEE 180
  181 EDDEQDFMDE TPHIKEE

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 5.77
Match: 1pz7A
Description: Modulation of agrin function by alternative splicing and Ca2+ binding
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
extracellular matrix structural constituent 4.9587779362039 bayes_pls_golite062009
glycosaminoglycan binding 2.52684550673329 bayes_pls_golite062009
fibronectin binding 2.46930149922943 bayes_pls_golite062009
binding 2.36160381896665 bayes_pls_golite062009
transcription regulator activity 2.17920418295591 bayes_pls_golite062009
polysaccharide binding 2.16789652353076 bayes_pls_golite062009
nucleic acid binding 1.9830722589036 bayes_pls_golite062009
DNA binding 1.82525586215701 bayes_pls_golite062009
protein binding 1.78031360242224 bayes_pls_golite062009
receptor activity 1.77396325197931 bayes_pls_golite062009
transmembrane receptor activity 1.72892726774108 bayes_pls_golite062009
signal transducer activity 1.69219314980524 bayes_pls_golite062009
molecular transducer activity 1.69219314980524 bayes_pls_golite062009
carbohydrate binding 1.60205275599272 bayes_pls_golite062009
heparin binding 1.48860421410709 bayes_pls_golite062009
transcription activator activity 1.26968013346197 bayes_pls_golite062009
transcription repressor activity 1.26658862258675 bayes_pls_golite062009
transporter activity 1.25957423734038 bayes_pls_golite062009
transcription factor activity 1.16784442642933 bayes_pls_golite062009
extracellular matrix binding 1.1514513943243 bayes_pls_golite062009
sugar binding 1.14124441774262 bayes_pls_golite062009
transmembrane transporter activity 1.04270043888428 bayes_pls_golite062009
receptor binding 0.909114404082345 bayes_pls_golite062009
growth factor activity 0.848003781759354 bayes_pls_golite062009
growth factor binding 0.810577516483879 bayes_pls_golite062009
substrate-specific transporter activity 0.778809723141833 bayes_pls_golite062009
pattern binding 0.666119751267046 bayes_pls_golite062009
cytokine binding 0.646928714072463 bayes_pls_golite062009
monosaccharide binding 0.624657026252492 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.526287085745855 bayes_pls_golite062009
protein kinase activity 0.358328289529296 bayes_pls_golite062009
zymosan binding 0.325250916876747 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.155087758481234 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.130242121480916 bayes_pls_golite062009
kinase activity 0.0933699760742077 bayes_pls_golite062009

Predicted Domain #10
Region A:
Residues: [1377-1504] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PVDPCLENKC RRGSRCVPNS NARDGYQCKC KHGQRGRYCD QGEGSTEPPT VTAASTCRKE  60
   61 QVREYYTEND CRSRQPLKYA KCVGGCGNQC CAAKIVRRRK VRMVCSNNRK YIKNLDIVRK 120
  121 CGCTKKCY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.221849
Match: 1danL
Description: Coagulation factor VIIa
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle