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Protein Overview: Sin3A-PD

General Information:
Name(s) found: Sin3A-PD / FBpp0087002 [FlyBase]
Description(s) found:
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  • gi|24653102|ref|NP_725189.1| Sin3A, isoform D [Drosophila melanogaster] [NCBI NR]
  • gi|21627312|gb|AAM68625.1| Sin3A, isoform D [Drosophila melanogaster] [NCBI NR]
  • The gene Sin3A is referred to in FlyBase by the symbol Dmel\Sin3A (CG8815, FBgn0022764). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:8462743..8480397. It has the cytological map location 49B5-49B7. There is experimental evidence that it has the molecular function</span>: transcription repressor activity. There is experimental evidence that it is involved in the biological process</span>: negative regulation of transcription; dendrite morphogenesis; neuron development; regulation of mitotic cell cycle; muscle organ development; negative regulation of transcription, DNA-dependent. 51 alleles are reported. The phenotypes of these alleles are annotated with: embryonic heart; mitochondrion; crystal cell. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
  • >CG8815-PD translation from_gene[CG8815 Sin3A FBgn0022764] seq_release:3 mol_weight=186845 cds_boundaries:(2R:7,643,250..7,650,424[-]) aa_length:1751 transcript_info:[CG8815-RD seq_release:3] gene_info:[gene symbol:Sin3A FBgn0022764 gene_boundaries:(2R [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q8ML44) CG8815-PD [DrosMelano7227.FASTAC.txt]
  • CG8815-PD, isoform D [Drosophila melanogaster]gi|24653102|ref|NP_725189.1| CG8815-PD [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=2R:complement(8466039..8466056,8466634..8466861,8466920..8467126,8467229..8467558,8467621..8468135,8468707..8469082,8469144..8469444,8469794..8471334,8471406..8472688,8472760..8473216); ID=FBpp0087002; name=Sin3A-PD; parent=FBgn0022764,F [fly-100309-contam.fasta]
  • CG8815-PD, isoform D [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Sin3A CG8815-PD, isoform D [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=2R:complement(8466039..8466056,8466634..8466861,8466920..8467126,8467229..8467558,8467621..8468135,8468707..8469082,8469144..8469444,8469794..8471334,8471406..8472688,8472760..8473216); ID=FBpp0087002; name=Sin3A-PD; parent=FBgn0022764,FBtr0087889; dbxref=GB_protein:AAM68625.1,FlyBase:FBpp0087002,FlyBase_Annotation_IDs:CG8815-PD,REFSEQ:NP_725189,GB_protein:AAM68625; MD5=ae36194f30f97f432543117c583a3505; length=1751; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=2R:complement(8466039..8466056,8466634..8466861,8466920..8467126,8467229..8467558,8467621..8468135,8468707..8469082,8469144..8469444,8469794..8471334,8471406..8472688,8472760..8473216); ID=FBpp0087002; name=Sin3A-PD; parent=FBgn0022764,FBtr0087889; dbxref=GB_protein:AAM68625.1,FlyBase:FBpp0087002,FlyBase_Annotation_IDs:CG8815-PD,REFSEQ:NP_725189,GB_protein:AAM68625; MD5=ae36194f30f97f432543117c583a3505; length=1751; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Sin3A, isoform D OS=Drosophila melanogaster GN=Sin3A PE=4 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=2R:complement(8466039..8466056,8466634..8466861,8466920..8467126,8467229..8467558,8467621..8468135,8468707..8469082,8469144..8469444,8469794..8471334,8471406..8472688,8472760..8473216); ID=FBpp0087002; name=Sin3A-PD; parent=FBgn0022764,FBtr0087889; dbxref=GB_protein:AAM68625.1,FlyBase:FBpp0087002,FlyBase_Annotation_IDs:CG8815-PD,REFSEQ:NP_725189,GB_protein:AAM68625,FlyMine:FBpp0087002,modMine:FBpp0087002; MD5=ae36194f30f97f432543117c583a3505; length=1751; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=2R:complement(join(12585255..12585711,12583901..12585183,12582289..12583829,12581639..12581939,12581202..12581577,12580116..12580630,12579724..12580053,12579415..12579621,12579129..12579356,12578534..12578551)); ID=FBpp0087002; name=Sin3A-PD; parent=FBgn0022764,FBtr0087889; dbxref=GB_protein:AAM68625.1,FlyBase:FBpp0087002,FlyBase_Annotation_IDs:CG8815-PD,REFSEQ:NP_725189,GB_protein:AAM68625,FlyMine:FBpp0087002,modMine:FBpp0087002; MD5=ae36194f30f97f432543117c583a3505; length=1751; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=2R:complement(join(12585255..12585711,12583901..12585183,12582289..12583829,12581639..12581939,12581202..12581577,12580116..12580630,12579724..12580053,12579415..12579621,12579129..12579356,12578534..12578551)); ID=FBpp0087002; name=Sin3A-PD; parent=FBgn0022764,FBtr0087889; dbxref=GB_protein:AAM68625.1,FlyBase:FBpp0087002,FlyBase_Annotation_IDs:CG8815-PD,REFSEQ:NP_725189,GB_protein:AAM68625,FlyMine:FBpp0087002,modMine:FBpp0087002; MD5=ae36194f30f97f432543117c583a3505; length=1751; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Isoform of A0A0B4K765, Sin3A, isoform D OS=Drosophila melanogaster GN=Sin3A PE=1 SV=1 [DROME.fasta.20160308]
  • FBpp0087002 type=protein; loc=2R:complement(join(12585255..12585711,12583901..12585183,12582289..12583829,12581639..12581939,12581202..12581577,12580116..12580630,12579724..12580053,12579415..12579621,12579129..12579356,12578534..12578551)); ID=FBpp0087002; name=Sin3A-PD; parent=FBgn0022764,FBtr0087889; dbxref=GB_protein:AAM68625.1,FlyBase:FBpp0087002,FlyBase_Annotation_IDs:CG8815-PD,REFSEQ:NP_725189,GB_protein:AAM68625,FlyMine:FBpp0087002,modMine:FBpp0087002; MD5=ae36194f30f97f432543117c583a3505; length=1751; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=2R:complement(join(12585255..12585711,12583901..12585183,12582289..12583829,12581639..12581939,12581202..12581577,12580116..12580630,12579724..12580053,12579415..12579621,12579129..12579356,12578534..12578551)); ID=FBpp0087002; name=Sin3A-PD; parent=FBgn0022764,FBtr0087889; dbxref=GB_protein:AAM68625.1,FlyBase:FBpp0087002,FlyBase_Annotation_IDs:CG8815-PD,REFSEQ:NP_725189,GB_protein:AAM68625,UniProt/TrEMBL:A1Z928,FlyMine:FBpp0087002,modMine:FBpp0087002; MD5=ae36194f30f97f432543117c583a3505; length=1751; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 1751 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA][ISS][NAS]
    euchromatin [TAS]
    cytoplasm [IDA]
    Sin3 complex [NAS]
    chromatin [IDA]
    Biological Process: muscle organ development [IMP]
    negative regulation of transcription, DNA-dependent [IMP][TAS]
    negative regulation of transcription [IEP]
    peripheral nervous system development [TAS]
    regulation of transcription, DNA-dependent [IEA]
    neuron development [IMP]
    regulation of transcription [ISS]
    regulation of mitotic cell cycle [IMP]
    dendrite morphogenesis [IMP]
    Molecular Function: transcription factor activity [ISS]
    transcription cofactor activity [NAS]
    RNA polymerase II transcription factor activity [NAS]
    transcription repressor activity [IDA][IMP]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMKRTRVDEV QFGTRPVPQT SGGVGVGVVG VTGGGPTSGG GGTATVGVNT TGVTIGTVVP  60
   61 SAHNATISGI GSIHHRILTP QHGGAQTIAY LPSTTPTATN LKTTTSIVDS TTAGGPVGAG 120
  121 AQVAVGVGSA AGGGGVVVST GSTGTQTLQY TTSYSVASIQ AGGTLKANTA DGANTVQIHV 180
  181 TGGGAANNPA SAQTVSSSSQ TGTIRQRTIS GTQTVATAVG NLATISQQQP VQQSPLGKAQ 240
  241 TPPSSVVANS IPVGGTTPPQ GQSGNATPRL KVEDALSYLD QVKYQYADQP QIYNNFLDIM 300
  301 KEFKSHCIDT PGVIERVSTL FKGHTELIYG FNMFLPPGYK IEIHSDALGC SVPVVSMPSP 360
  361 PGAPTSTGTV HMLTGNSSMS GAGHIAIKTT NAATLTPAAG AGAAAAAAAV AQIQSAGAVN 420
  421 LMTHGGASLT QTTIHALQQA TPPQSQSPGG GHVHVSVTNS TAANAVVPGQ PGISVSAHNV 480
  481 PQNYSRDRER ATITPTGQVA GAAANVNASA SIVVGGPPTP NSLSELSPHG GAGGGPGAGA 540
  541 AQHNLHHIQQ AHQSILLGET GQQNQPVEFN HAITYVNKIK NRFQNQPAKY KKFLEILHDY 600
  601 QREQKVMKEG SLNQGKMLTE QEVYTQVAKL FGQDEDLLRE FGQFLPDATN HQSGQYMSKS 660
  661 ASVHNDHGKR PTATLSGGAH ITMSSASPAP SGSPLHLGAT TLPQIDKSAH AAAIGNLSAV 720
  721 NTSVSIKTYN NNQQQQNHVI GSGLNATRND ILFEKDYHAG LQQQAHQRGA GVGGHHHLAG 780
  781 TAAGANIGRP GVGASVMVSY DKEHRNNHHV QKYVGHAPNQ NLTHGHNAKK SPSYGIPSVI 840
  841 GSMPHISDNS LDRSSPGISY ATPPLPSGPH GQHNSGSATR RPGDDSLVGH YASGAPPAKR 900
  901 PKPYCRDVSF SEASSKCTIS DAAFFDKVRK ALRSPEVYDN FLRCLTLFNQ EIVSKTELLG 960
  961 LVSPFLMKFP DLLRWFTDFL GPPSGQPAGG LIDGMPLAAT QRQGGGSSNS SHDRGTSHQS1020
 1021 AAEYVQDVDL SSCKRLGASY CALPQSTVPK KCSGRTALCR EVLNDKWVSF PTWASEDSTF1080
 1081 VTSRKTQFEE TIYRTEDERF ELDLVIEVNS ATIRVLENLQ KKMSRMSTEE LSKFHLDDHL1140
 1141 GGTSQTIHQR AIHRIYGDKS GEIITGMKKN PFVAVPIVLK RLKVKEEEWR EAQKTFNKQW1200
 1201 REQNEKYYLK SLDHQAINFK PNDMKALRSK SLFNEIETLY DERHDQEDDA MEPFGPHLVL1260
 1261 PYKDKTILDD AANLLIHHVK RQTGIQKQEK QKIKQIIRQF VPDLFFAPRQ PLSDDERDDA1320
 1321 FPFLVDDNTK MDVDSPLGRT ESSTRNAKST PSESASPARS NASTSSVTPA GIKKETDDSK1380
 1381 ATTGSFAPAS SATASSATPV DDATPSTSSA AAAASAASSS TVSGTEGKPK DDPLSSHKEE1440
 1441 GAGSTSSGVA TSPRQAQDTA GAGVDVEIKL EHPADFSNPK LLPPHAHGQR EDESYTLFFA1500
 1501 NNNWYLFLRL HAILCDRLHV MYERARLLAI EEERCRVNRR ESTATALRLK PKPEIQVEDY1560
 1561 YPTFLDMLKN VLDGNMDSNT FEDTMREMFG IYAYISFTLD KVVSNAVRQL QYCVTERAAL1620
 1621 DCVELFATEQ RRGCTGGFCR DAHKTFDREM SYQRKAESIL NEENCFKVYI YKIDCRVTIE1680
 1681 LLDSEPEEVD KPAALKAQKF SKYVERLANP ALGGGGNTGR SDSALGNDSV VDGSDIKTEA1740
 1741 DEDTAEVNTK A

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..914] PSI-BLAST 93.522879 No description for 1y0fB was found.
    2 View Details [915..1008] FFAS03 1.86 No description for 2f05A was found.
    3 View Details [1009..1142] Pfam 64.376751 No description for PF08295.3 was found. No confident structure predictions are available.
    4 View Details [1143..1262] deduced N/A No confident structure predictions are available.
    5 View Details [1263..1551] FFAS03 1.41 THE BLUETONGUE VIRUS (BTV) CORE BINDS DSRNA
    6 View Details [1552..1673] deduced N/A No confident structure predictions are available.
    7 View Details [1674..1751] MSA 1.019994 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • protein deacetylase activity
    		•  4.85550095681437 bayes_pls_golite062009
  • histone deacetylase activity
    		•  4.80822599235131 bayes_pls_golite062009
  • transcription repressor activity
    		•  4.25514230798992 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.82193713323077 bayes_pls_golite062009
  • deacetylase activity
    		•  3.68673303770777 bayes_pls_golite062009
  • transcription corepressor activity
    		•  3.30769773581294 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.83214064778422 bayes_pls_golite062009
  • DNA binding
    		•  2.82083682611814 bayes_pls_golite062009
  • transcription factor binding
    		•  2.73494763175272 bayes_pls_golite062009
  • transcription cofactor activity
    		•  2.59356984380124 bayes_pls_golite062009
  • binding
    		•  2.59005615358803 bayes_pls_golite062009
  • transcription factor activity
    		•  1.99794029160509 bayes_pls_golite062009
  • protein binding
    		•  1.36724461365736 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.918453145717461 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
    		•  0.864804910849344 bayes_pls_golite062009
  • transcription activator activity
    		•  0.570282420961288 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  0.536470369536903 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.512364998565023 bayes_pls_golite062009
  • catalytic activity
    		•  0.30211814650972 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.44

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle