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Protein Overview: fra-PB

General Information:
Name(s) found: fra-PB / FBpp0086934 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene frazzled is referred to in FlyBase by the symbol Dmel\fra (CG8581, FBgn0011592). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:8416561..8451691. It has the cytological map location 49A10-49B3. It is reported to have molecular function</span>: netrin receptor activity. There is experimental evidence that it is involved in the biological process</span>: motor axon guidance; salivary gland boundary specification; axon guidance; axon midline choice point recognition; dendrite guidance. 23 alleles are reported. The phenotypes of these alleles are annotated with 13 unique terms, many of which group under: multi-cell-component structure; embryonic nervous system; nervous system; commissure; organ system; embryonic neuron; peripheral nervous system; supraesophageal ganglion neuron; adult segment; larval head nerve; embryonic foregut. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1375 amino acids

    Gene Ontology:
    Cellular Component: dendrite [IDA]
    integral to membrane [IEA]
    neuronal cell body [IDA]
    plasma membrane [ISS]
    axon [IDA]
    Biological Process: motor axon guidance [IMP]
    salivary gland boundary specification [IMP]
    axon guidance [IMP][NAS][TAS]
    axon midline choice point recognition [IMP]
    dendrite guidance [IMP]
    dendrite morphogenesis [TAS]
    Molecular Function: netrin receptor activity [NAS][TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAITTNRSSR TLWNWLLSSC LIFQLIGSSL ASQALSFTLE PQDAVVPEGH SVLLQCAGTA  60
   61 SIGRGGKSKS NLPSSVSIRW RGPDGQDLVI VGDTFRTQLK NGSLYISSVE ENRGLTGAYQ 120
  121 CLLTAEGVGS ILSRPALVAI VRQPDLNQDF LETYLLPGQT AYFRCMLGEA NWQEGVKHSV 180
  181 QWLKDDLPLP LDKLRMVVLP NGALEIDEVG PSDRGSYQCN VTSGSSSRLS SKTNLNIKKP 240
  241 SDPGAENSVA PSFLVGPSPK TVREGDTVTL DCVANGVPKP QIKWLRNGMD LDFNDLDSRF 300
  301 SIVGTGSLQI SSAEDIDSGN YQCRASNTVD SLDAQATVQV QEPPKFIKAP KDTTAHEKDE 360
  361 PELKCDIWGK PKPVIRWLKN GDLITPNDYM QLVDGHNLKI LGLLNSDAGM FQCVGTNAAG 420
  421 SVHAAARLRV VPQGDSPEQD PSVPHPGGKP LDSGLQARLP SQPRDLVAQI VKSRFVTLSW 480
  481 VEPLQNAGDV VYYTVYYKMN NSEREQKMVT KSHDDQQVNI QSLLPGRTYQ FRVEANTNFG 540
  541 SGASSAPLEV STQPEVNIAG PPRNFEGYAR SHKEIYVKWE EPTVTNGEIL KYRVYYSEND 600
  601 SGADLYHDST ALEAVLTELR PHTDYVISVV PFNRNGMGDS SAEIRVKTFS STPSEPPNNV 660
  661 TLEVTSSSSI TVHWEPPAEE DRNGQITGYK IRYRKFKDAP QVKSTPANIR YFELSNLDRN 720
  721 AEYQVKIAAM TVNGSGPFTE WNRANTLEND LDETQVPGKP IWISIHPGAN NIALHWGPPQ 780
  781 HPEIKIRNYV LGWGRGIPDE NTIELKETER YHILKNLESN MDYVVSLRAR NVKGDGPPIY 840
  841 DNIKTRDEEP VDAPTPLEVP VGLRAITMSS SSIVVYWIDT MLNKNQHVTD NRHYTVSYGI 900
  901 TGSNRYRYHN TTDLNCMIND LRPNTQYEFA VKVVKGRRES SWSMSVLNST YQNVPVTPPR 960
  961 EVTVRLDEMN PPTVIVQWIP PKHTLGQITG YNIYYTTDTT KRDRDWSVEA FAGEETMLML1020
 1021 PNLKPYTTYY FKVQARTTKG ANNAPFSALV SYTTSAAVTM QEPDTIAKGI DNEKLLYIII1080
 1081 AATAVVLLVV LLGVLLLCRR KPQSSPEHTK KSYQKNNVGV PKPPDLWIHH DQMELKNIDK1140
 1141 GLHTVTPVCS DGASSSGALT LPRSVVHSEY EVETPVPGHV TNSLDKRSYV PGYMTTSMNG1200
 1201 TMERPQYPRT QYSHQNRSHM TMEAGLSQQS LTQPQSNSMA QTPEHPYGGY DANFCNAGNA1260
 1261 AAGNGCVSTI ESSKRGHPLK SFSVPGPPPT GGATPVTKHT PAVTIRPQNQ SPYKKPSFSA1320
 1321 ATPNRLQGGG SVVHSTDEIQ RLAPSTSTEE LNQEMANLEG LMKDLSAITA NEFEC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..123] PSI-BLAST 63.522879 Axonin-1
    2 View Details [124..348] PSI-BLAST 6.221849 The Crystal Structure of ICAM-1 D3-D5 fragment
    3 View Details [349..439] PSI-BLAST 29.522879 No description for 2iepA was found.
    4 View Details [440..556] PSI-BLAST 32.154902 No description for 2nziA was found.
    5 View Details [557..655] PSI-BLAST 12.69897 The solution structure of the second fibronectin type III domain of human Neogenin
    6 View Details [656..752] PSI-BLAST 16.0 The solution structure of the third fibronectin type III domain of human Neogenin
    7 View Details [753..845] PSI-BLAST 14.0 The solution structure of the fourth fibronectin type III domain of human Neogenin
    8 View Details [846..938] PSI-BLAST 20.0 Integin beta-4 subunit
    9 View Details [939..1203] PSI-BLAST 15.0 CRYSTAL STRUCTURE OF TANDEM TYPE III FIBRONECTIN DOMAINS FROM DROSOPHILA NEUROGLIAN AT 2.0 ANGSTROMS
    10 View Details [1204..1375] MSA 2.188989 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • fibroblast growth factor 1 binding
    		•  6.68503380812062 bayes_pls_golite062009
  • fibroblast growth factor binding
    		•  3.54458347746523 bayes_pls_golite062009
  • receptor activity
    		•  3.43161288468336 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  3.21639072755286 bayes_pls_golite062009
  • fibroblast growth factor receptor activity
    		•  3.20458334492494 bayes_pls_golite062009
  • binding
    		•  3.17641566810715 bayes_pls_golite062009
  • olfactory receptor activity
    		•  3.11478925068162 bayes_pls_golite062009
  • peptide antigen binding
    		•  2.94721224577771 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.65769780435188 bayes_pls_golite062009
  • signal transducer activity
    		•  2.65769780435188 bayes_pls_golite062009
  • growth factor binding
    		•  2.28613301180608 bayes_pls_golite062009
  • protein binding
    		•  2.22855404705168 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  1.52958974617075 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  1.36789541796983 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  1.30657787244536 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  0.904613290855333 bayes_pls_golite062009
  • protein complex binding
    		•  0.83543827718565 bayes_pls_golite062009
  • receptor binding
    		•  0.632627479346393 bayes_pls_golite062009
  • cytokine binding
    		•  0.631436442105379 bayes_pls_golite062009
  • IgG binding
    		•  0.61723245594762 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.394338877297952 bayes_pls_golite062009
  • cytokine receptor activity
    		•  0.34165331857492 bayes_pls_golite062009
  • integrin binding
    		•  0.32413307774101 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.316848380982695 bayes_pls_golite062009
  • DNA binding
    		•  0.304320681250924 bayes_pls_golite062009
  • peptide binding
    		•  0.0686742956437796 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • ankyrin binding
    		•  4.69755754047169 bayes_pls_golite062009
  • cytokine binding
    		•  4.43581512268554 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  4.21125462030555 bayes_pls_golite062009
  • receptor activity
    		•  4.09185309744435 bayes_pls_golite062009
  • cytokine receptor activity
    		•  4.08668869714207 bayes_pls_golite062009
  • growth factor binding
    		•  4.06808996928726 bayes_pls_golite062009
  • protein binding
    		•  3.24522318184038 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.24090483126624 bayes_pls_golite062009
  • signal transducer activity
    		•  3.24090483126624 bayes_pls_golite062009
  • binding
    		•  3.12471204223368 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  2.32179186005318 bayes_pls_golite062009
  • prolactin receptor activity
    		•  2.15346920063421 bayes_pls_golite062009
  • peptide hormone binding
    		•  2.12033076929638 bayes_pls_golite062009
  • polysaccharide binding
    		•  1.69642470905172 bayes_pls_golite062009
  • interleukin-6 binding
    		•  1.68148907423073 bayes_pls_golite062009
  • interleukin-6 receptor activity
    		•  1.68148907423073 bayes_pls_golite062009
  • interleukin-2 binding
    		•  1.67132604890013 bayes_pls_golite062009
  • axon guidance receptor activity
    		•  1.64934167161651 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  1.6158868405814 bayes_pls_golite062009
  • heparin binding
    		•  1.40418056272895 bayes_pls_golite062009
  • receptor binding
    		•  1.31676259534833 bayes_pls_golite062009
  • interleukin-11 receptor activity
    		•  0.89226024139982 bayes_pls_golite062009
  • interleukin-11 binding
    		•  0.89226024139982 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.86564366658585 bayes_pls_golite062009
  • ciliary neurotrophic factor receptor activity
    		•  0.80236858232025 bayes_pls_golite062009
  • identical protein binding
    		•  0.564711394496051 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  0.554350228628563 bayes_pls_golite062009
  • transcription activator activity
    		•  0.529736394173061 bayes_pls_golite062009
  • hormone binding
    		•  0.49524185948356 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.470959482317512 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.46168925186147 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.399167806498504 bayes_pls_golite062009
  • DNA binding
    		•  0.310798383307903 bayes_pls_golite062009
  • pattern binding
    		•  0.30071837231983 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  0.298447910128479 bayes_pls_golite062009
  • peptide binding
    		•  0.25993774667015 bayes_pls_golite062009
  • transcription factor binding
    		•  0.210682741845199 bayes_pls_golite062009
  • oncostatin-M receptor activity
    		•  0.162564792938799 bayes_pls_golite062009
  • leukemia inhibitory factor receptor activity
    		•  0.162564792938799 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.1430595594485 bayes_pls_golite062009
  • protein homodimerization activity
    		•  0.116391819218123 bayes_pls_golite062009
  • interleukin-2 receptor activity
    		•  0.115337814289139 bayes_pls_golite062009
  • cell surface binding
    		•  0.0745834027611858 bayes_pls_golite062009
  • growth factor activity
    		•  0.0477008672713168 bayes_pls_golite062009
    6
    Term Confidence Notes
  • ankyrin binding
    		•  4.69755754047169 bayes_pls_golite062009
  • cytokine binding
    		•  4.43581512268554 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  4.21125462030555 bayes_pls_golite062009
  • receptor activity
    		•  4.09185309744435 bayes_pls_golite062009
  • cytokine receptor activity
    		•  4.08668869714207 bayes_pls_golite062009
  • growth factor binding
    		•  4.06808996928726 bayes_pls_golite062009
  • protein binding
    		•  3.24522318184038 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.24090483126624 bayes_pls_golite062009
  • signal transducer activity
    		•  3.24090483126624 bayes_pls_golite062009
  • binding
    		•  3.12471204223368 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  2.32179186005318 bayes_pls_golite062009
  • prolactin receptor activity
    		•  2.15346920063421 bayes_pls_golite062009
  • peptide hormone binding
    		•  2.12033076929638 bayes_pls_golite062009
  • polysaccharide binding
    		•  1.69642470905172 bayes_pls_golite062009
  • interleukin-6 binding
    		•  1.68148907423073 bayes_pls_golite062009
  • interleukin-6 receptor activity
    		•  1.68148907423073 bayes_pls_golite062009
  • interleukin-2 binding
    		•  1.67132604890013 bayes_pls_golite062009
  • axon guidance receptor activity
    		•  1.64934167161651 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  1.6158868405814 bayes_pls_golite062009
  • heparin binding
    		•  1.40418056272895 bayes_pls_golite062009
  • receptor binding
    		•  1.31676259534833 bayes_pls_golite062009
  • interleukin-11 receptor activity
    		•  0.89226024139982 bayes_pls_golite062009
  • interleukin-11 binding
    		•  0.89226024139982 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.86564366658585 bayes_pls_golite062009
  • ciliary neurotrophic factor receptor activity
    		•  0.80236858232025 bayes_pls_golite062009
  • identical protein binding
    		•  0.564711394496051 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  0.554350228628563 bayes_pls_golite062009
  • transcription activator activity
    		•  0.529736394173061 bayes_pls_golite062009
  • hormone binding
    		•  0.49524185948356 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.470959482317512 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.46168925186147 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.399167806498504 bayes_pls_golite062009
  • DNA binding
    		•  0.310798383307903 bayes_pls_golite062009
  • pattern binding
    		•  0.30071837231983 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  0.298447910128479 bayes_pls_golite062009
  • peptide binding
    		•  0.25993774667015 bayes_pls_golite062009
  • transcription factor binding
    		•  0.210682741845199 bayes_pls_golite062009
  • oncostatin-M receptor activity
    		•  0.162564792938799 bayes_pls_golite062009
  • leukemia inhibitory factor receptor activity
    		•  0.162564792938799 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.1430595594485 bayes_pls_golite062009
  • protein homodimerization activity
    		•  0.116391819218123 bayes_pls_golite062009
  • interleukin-2 receptor activity
    		•  0.115337814289139 bayes_pls_golite062009
  • cell surface binding
    		•  0.0745834027611858 bayes_pls_golite062009
  • growth factor activity
    		•  0.0477008672713168 bayes_pls_golite062009
    7
    Term Confidence Notes
  • ankyrin binding
    		•  4.69755754047169 bayes_pls_golite062009
  • cytokine binding
    		•  4.43581512268554 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  4.21125462030555 bayes_pls_golite062009
  • receptor activity
    		•  4.09185309744435 bayes_pls_golite062009
  • cytokine receptor activity
    		•  4.08668869714207 bayes_pls_golite062009
  • growth factor binding
    		•  4.06808996928726 bayes_pls_golite062009
  • protein binding
    		•  3.24522318184038 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.24090483126624 bayes_pls_golite062009
  • signal transducer activity
    		•  3.24090483126624 bayes_pls_golite062009
  • binding
    		•  3.12471204223368 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  2.32179186005318 bayes_pls_golite062009
  • prolactin receptor activity
    		•  2.15346920063421 bayes_pls_golite062009
  • peptide hormone binding
    		•  2.12033076929638 bayes_pls_golite062009
  • polysaccharide binding
    		•  1.69642470905172 bayes_pls_golite062009
  • interleukin-6 binding
    		•  1.68148907423073 bayes_pls_golite062009
  • interleukin-6 receptor activity
    		•  1.68148907423073 bayes_pls_golite062009
  • interleukin-2 binding
    		•  1.67132604890013 bayes_pls_golite062009
  • axon guidance receptor activity
    		•  1.64934167161651 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  1.6158868405814 bayes_pls_golite062009
  • heparin binding
    		•  1.40418056272895 bayes_pls_golite062009
  • receptor binding
    		•  1.31676259534833 bayes_pls_golite062009
  • interleukin-11 receptor activity
    		•  0.89226024139982 bayes_pls_golite062009
  • interleukin-11 binding
    		•  0.89226024139982 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.86564366658585 bayes_pls_golite062009
  • ciliary neurotrophic factor receptor activity
    		•  0.80236858232025 bayes_pls_golite062009
  • identical protein binding
    		•  0.564711394496051 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  0.554350228628563 bayes_pls_golite062009
  • transcription activator activity
    		•  0.529736394173061 bayes_pls_golite062009
  • hormone binding
    		•  0.49524185948356 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.470959482317512 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.46168925186147 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.399167806498504 bayes_pls_golite062009
  • DNA binding
    		•  0.310798383307903 bayes_pls_golite062009
  • pattern binding
    		•  0.30071837231983 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  0.298447910128479 bayes_pls_golite062009
  • peptide binding
    		•  0.25993774667015 bayes_pls_golite062009
  • transcription factor binding
    		•  0.210682741845199 bayes_pls_golite062009
  • oncostatin-M receptor activity
    		•  0.162564792938799 bayes_pls_golite062009
  • leukemia inhibitory factor receptor activity
    		•  0.162564792938799 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.1430595594485 bayes_pls_golite062009
  • protein homodimerization activity
    		•  0.116391819218123 bayes_pls_golite062009
  • interleukin-2 receptor activity
    		•  0.115337814289139 bayes_pls_golite062009
  • cell surface binding
    		•  0.0745834027611858 bayes_pls_golite062009
  • growth factor activity
    		•  0.0477008672713168 bayes_pls_golite062009
    8 No functions predicted.
    9 No functions predicted.
    10 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle