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Protein Overview: S2P-PA

General Information:
Name(s) found: S2P-PA / FBpp0087169 [FlyBase]
Description(s) found:
Found 23 descriptions.
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  • The gene S2P is referred to in FlyBase by the symbol Dmel\S2P (CG8988, FBgn0033656). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:7729608..7731743. It has the cytological map location 48C4. Based on sequence similarity, it is predicted to have molecular function</span>: metallopeptidase activity. It is reported to be involved in the biological process</span>: sterol regulatory element binding protein cleavage. 6 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 508 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEA]
    Biological Process: proteolysis [IEA]
    sterol regulatory element binding protein cleavage [NAS]
    Molecular Function: metalloendopeptidase activity [IEA][NAS]
    metallopeptidase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDPFVFFIVL ASLYGVLYFF DRFFKSCMHY PYDAFLKNTG LSINFMSLHW HTSAFNRTLL  60
   61 RWGSAGNSCT RRVMITSFNV GVLVTFSLLP IGLILLIATI FSSGEQDSSS SVSSPVGVPV 120
  121 QLEILLPGVN LPLEEIGYYI TTLVLCLVVH EMGHALAAVM EDVPVTGFGI KFIFCLPLAY 180
  181 TELSHDHLNS LRWFRKLRVL CAGIWHNFVF AGVCYLLIST VGITMSPLYA YNQHVVVTEL 240
  241 TRKSPLRGER GLQVDNQITQ VNGCPVNSEE SWVTCLQNSL KLKPGYCVSA DFVQLNDESS 300
  301 AISHHSIDGQ LQCCDELNPN VSCFEVVEDA NGDVPVELPQ HVCLNVRRTL EEVSEHCSSG 360
  361 VCNEGFCLRP LIRNITAIMT FKRQNFRGEK LPPVIYVGHP WDVTRTVEVS AFVPRYSLLK 420
  421 AAWPDAWLLL LKYNVVFSIG LALINAIPCF GFDGAHITST VIHSFLVGRV DQHAKRDIIS 480
  481 LIITSVGSLL FALALLKVAW LSFLRPLL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..175] FFAS03 1.08 STRUCTURE OF ASTACIN AND IMPLICATIONS FOR ACTIVATION OF ASTACINS AND ZINC-LIGATION OF COLLAGENASES
    2 View Details [176..372] PSI-BLAST 10.30103 Protease Do (DegP, HtrA), C-terminal domains; Protease Do (DegP, HtrA), catalytic domain
    3 View Details [373..508] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • peptidase activity
    		•  1.76643938645269 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  1.57367268366308 bayes_pls_golite062009
  • signal transducer activity
    		•  1.444735183839 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.444735183839 bayes_pls_golite062009
  • binding
    		•  1.3490975726156 bayes_pls_golite062009
  • metallopeptidase activity
    		•  1.24580608250291 bayes_pls_golite062009
  • receptor activity
    		•  0.904780617101885 bayes_pls_golite062009
  • catalytic activity
    		•  0.843772148375291 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.816421865388692 bayes_pls_golite062009
  • metalloendopeptidase activity
    		•  0.630465203930357 bayes_pls_golite062009
  • protein binding
    		•  0.52577122893671 bayes_pls_golite062009
  • endopeptidase activity
    		•  0.459012819207862 bayes_pls_golite062009
    2
    Term Confidence Notes
  • binding
    		•  2.6196222853442 bayes_pls_golite062009
  • protein binding
    		•  2.35875654816667 bayes_pls_golite062009
  • signal transducer activity
    		•  1.51162321843898 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.51162321843898 bayes_pls_golite062009
  • protein domain specific binding
    		•  0.25368357134857 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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