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The hydrolysis of a peptide bond or bonds within a protein as part of protein maturation, the process leading to the attainment of the full functional capacity of a protein. Any series of molecular signals that conveys information from the endoplasmic reticulum to the nucleus, usually resulting in a change in transcriptional regulation. A series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of altered levels of one or more lipids, and resulting in the activation of transcription by SREBP. The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells. Any protein maturation process achieved by the cleavage of peptide bonds. The proteolytic release of a transcriptionally active sterol regulatory element binding protein (SREBP) from intracellular membranes, freeing it to move to the nucleus and upregulate transcription of target genes, in response to depleted sterol levels. The proteolytic release of a transcriptionally active sterol regulatory element binding protein (SREBP) from intracellular membranes, freeing it to move to the nucleus and upregulate transcription of target genes, in response to altered levels of one or more lipids. The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: sterol regulatory element binding protein cleavage
Acc: GO:0035103
Aspect: Biological Process
Desc: The proteolytic release of a transcriptionally active sterol regulatory element binding protein (SREBP) from intracellular membranes, freeing it to move to the nucleus and upregulate transcription of target genes, in response to altered levels of one or more lipids.
Synonyms:
  • SREBP cleavage
Proteins in PDR annotated with:
   This term: 6 [Search]
   Term or descendants: 7 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0035103 - sterol regulatory element binding protein cleavage (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle