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Protein Overview: CG42347-PB

General Information:
Name(s) found: CG42347-PB / FBpp0289206 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • This gene is referred to in FlyBase by the symbol Dmel\CG42347 (CG42347, FBgn0259678). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:5603981..5632778. It has the cytological map location 46B2. There is experimental evidence that it has the molecular function</span>: protein kinase activity. There is experimental evidence that it is involved in the biological process</span>: regulation of cell shape; positive regulation of TOR signaling pathway; protein amino acid phosphorylation; actin filament organization. 13 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 446 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: regulation of cell shape [IMP]
    actin filament organization [IMP]
    protein amino acid phosphorylation [IGI][NAS]
    positive regulation of TOR signaling pathway [IGI]
    Molecular Function: ATP binding [IEA]
    protein kinase activity [IGI]
    protein serine/threonine kinase activity [NAS]
    myosin light chain kinase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIYIDDSEPE GVLEPAFPMR DVTINRNVDA HKHYDVLGEV GRGKFGTVYK CRDKANGLQL  60
   61 AAKFVPIPKR EDKRNVEREV EIMNSLQHHL IIQLYAAYEY QKMMCVVLEL IEGGELFDRV 120
  121 VDDEFVLTER VCRVFIRQVC EAMAFIHGNG IVHLDLKPEN ILVLTQKGNR IKIIDFGLAR 180
  181 KFDPDKRLRV LFGTPEFVAP EVVNFDCISY GTDMWSVGVI CYVLISGLSP FMGENDIETM 240
  241 SNVTIAKYDF EDECFNGISP ECLDFIAKLL AKDLSTRMTA AECMKHKWLQ QRPATAATAT 300
  301 PITKAASAAS KSRLKSVSPV TAPSESSEDS TETIEDEDDE EEVAVQQAKQ KDQQQDEELA 360
  361 NLCGDAELEN KELDATKDNL KNFIVRWETH PNSPYVFDVE GNVIAPLSET SYPHPRRTHG 420
  421 ADSLSSSRGE YGSQRQRDRH ALIHGK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..339] PSI-BLAST 63.30103 Twitchin, kinase domain
    2 View Details [340..446] PSI-BLAST 14.045757 Regulatory apparatus of Calcium Dependent protein kinase from Arabidopsis thaliana

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • tubulin binding
    		•  2.18641675163967 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.12615078788254 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • microtubule binding
    		•  1.88110801192607 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.3898059094397 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.38496328649031 bayes_pls_golite062009
  • actin binding
    		•  1.33479685165255 bayes_pls_golite062009
  • gamma-tubulin binding
    		•  1.28511591054866 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.27291233344322 bayes_pls_golite062009
  • protein binding
    		•  1.22565748038754 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.612883428421652 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.499492353295369 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.391384757497683 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.35402045013148 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.351206771811872 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.340617390162297 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.339969855367828 bayes_pls_golite062009
  • signal transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • actin filament binding
    		•  0.2403700250846 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.08504542461349 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.0556163711947139 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.00652065412910241 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle