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Protein Overview: Su(var)2-10-PD

General Information:
Name(s) found: Su(var)2-10-PD / FBpp0087653 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene Suppressor of variegation 2-10 is referred to in FlyBase by the symbol Dmel\Su(var)2-10 (CG8068, FBgn0003612). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:5003631..5009507. It has the cytological map location 45A8-45A9. Based on sequence similarity, it is predicted to have molecular function</span>: DNA binding. There is experimental evidence that it is involved in the biological process</span>: compound eye development; chromosome organization; chromosome condensation. 21 alleles are reported. The phenotypes of these alleles are annotated with: eye; polytene chromosome; border follicle cell. It has 12 annotated transcripts and 12 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 601 amino acids

    Gene Ontology:
    Cellular Component: polytene chromosome, telomeric region [IDA]
    nucleus [IDA][TAS]
    polytene chromosome [IDA]
    cytoplasm [IDA][TAS]
    nuclear lamina [IDA]
    nucleoplasm [IDA]
    Biological Process: chromosome organization [IMP][TAS]
    hemopoiesis [TAS]
    chromosome condensation [IMP]
    regulation of protein catabolic process [TAS]
    regulation of JAK-STAT cascade [TAS]
    compound eye development [IMP][TAS]
    negative regulation of JAK-STAT cascade [NAS]
    imaginal disc growth [TAS]
    Molecular Function: nucleic acid binding [IEA]
    DNA binding [ISS]
    zinc ion binding [IEA]
    DEAD/H-box RNA helicase binding [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRKTRSQTAR TQAENAATSS SPGHQSTSSA PIAVNPFDST KYKECEQMVQ MLRVVELQKI  60
   61 LSFLNISFAG RKTDLQSRIL SFLRTNLELL APKVQEVYAQ SVQEQNATLQ YIDPTRMYSH 120
  121 IQLPPTVQPN PVGLVGSGQG VQVPGGQMNV VGGAPFLHTH SINSQLPIHP DVRLKKLAFY 180
  181 DVLGTLIKPS TLVPRNTQRV QEVPFYFTLT PQQATEIASN RDIRNSSKVE HAIQVQLRFC 240
  241 LVETSCDQED CFPPNVNVKV NNKLCQLPNV IPTNRPNVEP KRPPRPVNVT SNVKLSPTVT 300
  301 NTITVQWCPD YTRSYCLAVY LVKKLTSTQL LQRMKTKGVK PADYTRGLIK EKLTEDADCE 360
  361 IATTMLKVSL NCPLGKMKML LPCRASTCSH LQCFDASLYL QMNERKPTWN CPVCDKPAIY 420
  421 DNLVIDGYFQ EVLGSSLLKS DDTEIQLHQD GSWSTPGLRS ETQILDTPSK PAQKVEVISD 480
  481 DIELISDDAK PVKRDLSPAQ DEQPTSTSNS ETVDLTLSDS DDDMPLAKRR PPAKQAVASS 540
  541 TSNGSGGGQR AYTPAQQPQQ SGGNVFKKPQ KAEELYKRVH LGVWLRPRKP KPESSRRPNV 600
  601 G

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..102] PSI-BLAST 17.0 Solution structure of human p53 binding domain of PIAS-1
    2 View Details [103..209] deduced N/A No confident structure predictions are available.
    3 View Details [210..339] MSA 2.137984 View MSA. No confident structure predictions are available.
    4 View Details [340..462] PSI-BLAST 3.69897 brca1 RING domain
    5 View Details [463..601] MSA 8.120996 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • small conjugating protein ligase activity
    		•  5.55686022186257 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  5.24177189110056 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  4.59153177011595 bayes_pls_golite062009
  • binding
    		•  2.78710909602478 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.72498741013971 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  2.57382484274962 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.32387297115017 bayes_pls_golite062009
  • DNA binding
    		•  2.00904221080834 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.98209395225978 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.82615879438544 bayes_pls_golite062009
  • protein binding
    		•  1.5975811408548 bayes_pls_golite062009
  • SUMO polymer binding
    		•  1.45421060001117 bayes_pls_golite062009
  • transcription factor activity
    		•  1.22579085356684 bayes_pls_golite062009
  • small conjugating protein-specific protease activity
    		•  1.2126425713931 bayes_pls_golite062009
  • transcription factor binding
    		•  1.11842175076436 bayes_pls_golite062009
  • ubiquitin-specific protease activity
    		•  1.03469202541773 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.90321253993065 bayes_pls_golite062009
  • ligase activity
    		•  0.63517530468004 bayes_pls_golite062009
  • cysteine-type peptidase activity
    		•  0.50197530717959 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.384990496120483 bayes_pls_golite062009
  • hydrolase activity
    		•  0.295474423132249 bayes_pls_golite062009
  • ubiquitin thiolesterase activity
    		•  0.265769062717221 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.255669498391574 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.233838999434784 bayes_pls_golite062009
  • catalytic activity
    		•  0.14112008370434 bayes_pls_golite062009
  • transcription activator activity
    		•  0.126093965701234 bayes_pls_golite062009
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.89

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle