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View Structure Prediction Details

Protein: Su(var)2-10-PD
Organism: Drosophila melanogaster
Length: 601 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Su(var)2-10-PD.

Description E-value Query
Range		 Subject
Range
Su(var)2-10-PH - The gene Suppressor of variegation 2-10 is referred to in FlyBase by the symbol Dmel\Su(var)2-10 (CG...
 575.0 [0..1] [566..1]

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Predicted Domain #1
Region A:
Residues: [1-102] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRKTRSQTAR TQAENAATSS SPGHQSTSSA PIAVNPFDST KYKECEQMVQ MLRVVELQKI  60
   61 LSFLNISFAG RKTDLQSRIL SFLRTNLELL APKVQEVYAQ SV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.0
Match: 1v66A
Description: Solution structure of human p53 binding domain of PIAS-1
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [103-209] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QEQNATLQYI DPTRMYSHIQ LPPTVQPNPV GLVGSGQGVQ VPGGQMNVVG GAPFLHTHSI  60
   61 NSQLPIHPDV RLKKLAFYDV LGTLIKPSTL VPRNTQRVQE VPFYFTL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [210-339] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TPQQATEIAS NRDIRNSSKV EHAIQVQLRF CLVETSCDQE DCFPPNVNVK VNNKLCQLPN  60
   61 VIPTNRPNVE PKRPPRPVNV TSNVKLSPTV TNTITVQWCP DYTRSYCLAV YLVKKLTSTQ 120
  121 LLQRMKTKGV

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [340-462] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPADYTRGLI KEKLTEDADC EIATTMLKVS LNCPLGKMKM LLPCRASTCS HLQCFDASLY  60
   61 LQMNERKPTW NCPVCDKPAI YDNLVIDGYF QEVLGSSLLK SDDTEIQLHQ DGSWSTPGLR 120
  121 SET

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.69897
Match: 1jm7A
Description: brca1 RING domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
small conjugating protein ligase activity 5.55686022186257 bayes_pls_golite062009
ubiquitin-protein ligase activity 5.24177189110056 bayes_pls_golite062009
acid-amino acid ligase activity 4.59153177011595 bayes_pls_golite062009
binding 2.78710909602478 bayes_pls_golite062009
transcription regulator activity 2.72498741013971 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 2.57382484274962 bayes_pls_golite062009
nucleic acid binding 2.32387297115017 bayes_pls_golite062009
DNA binding 2.00904221080834 bayes_pls_golite062009
transcription repressor activity 1.98209395225978 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.82615879438544 bayes_pls_golite062009
protein binding 1.5975811408548 bayes_pls_golite062009
SUMO polymer binding 1.45421060001117 bayes_pls_golite062009
transcription factor activity 1.22579085356684 bayes_pls_golite062009
small conjugating protein-specific protease activity 1.2126425713931 bayes_pls_golite062009
transcription factor binding 1.11842175076436 bayes_pls_golite062009
ubiquitin-specific protease activity 1.03469202541773 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.90321253993065 bayes_pls_golite062009
ligase activity 0.63517530468004 bayes_pls_golite062009
cysteine-type peptidase activity 0.50197530717959 bayes_pls_golite062009
transcription corepressor activity 0.384990496120483 bayes_pls_golite062009
hydrolase activity 0.295474423132249 bayes_pls_golite062009
ubiquitin thiolesterase activity 0.265769062717221 bayes_pls_golite062009
transcription coactivator activity 0.255669498391574 bayes_pls_golite062009
transcription cofactor activity 0.233838999434784 bayes_pls_golite062009
catalytic activity 0.14112008370434 bayes_pls_golite062009
transcription activator activity 0.126093965701234 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [463-601] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QILDTPSKPA QKVEVISDDI ELISDDAKPV KRDLSPAQDE QPTSTSNSET VDLTLSDSDD  60
   61 DMPLAKRRPP AKQAVASSTS NGSGGGQRAY TPAQQPQQSG GNVFKKPQKA EELYKRVHLG 120
  121 VWLRPRKPKP ESSRRPNVG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle