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Protein Overview: Cul-4-PB, Cul-4-PA

General Information:
Name(s) found: Cul-4-PB / FBpp0290569 [FlyBase]
Cul-4-PA / FBpp0087897 [FlyBase]
Description(s) found:
Found 31 descriptions.
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  • The gene Cullin-4 is referred to in FlyBase by the symbol Dmel\Cul-4 (CG8711, FBgn0033260). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:3989765..3993819. It has the cytological map location 44A4. Based on sequence similarity, it is predicted to have molecular function</span>: ubiquitin-protein ligase activity. There is experimental evidence that it is involved in the biological process</span>: positive regulation of NFAT protein import into nucleus. 7 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • The gene Cullin-4 is referred to in FlyBase by the symbol Dmel\Cul-4 (CG8711, FBgn0033260). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:3989765..3993819. It has the cytological map location 44A4. Based on sequence similarity, it is predicted to have molecular function</span>: ubiquitin-protein ligase activity. There is experimental evidence that it is involved in the biological process</span>: positive regulation of NFAT protein import into nucleus. 7 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 821 amino acids

    Gene Ontology:
    Cellular Component: nuclear ubiquitin ligase complex [ISS]
    cullin-RING ubiquitin ligase complex [IEA]
    Biological Process: positive regulation of NFAT protein import into nucleus [IMP]
    protein ubiquitination during ubiquitin-dependent protein catabolic process [ISS]
    Molecular Function: ubiquitin-protein ligase activity [ISS]
    ubiquitin protein ligase binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAAKKYKPM DTTELHENTE NIAACLKKAE NVAPTAAAAS SVGRSAFAAQ NMNSASTNGE  60
   61 RLPNFSKLGG SHGEIRTAST TSNLLNRMGA IHNSKPGDVK KIVIKNFKDK PTLPDNYSKD 120
  121 TYVKLEEAVI AIQLSKPIKY SLEELYQAVV NMCSHKMDAQ LYAKLKELTE QHVKRNIKLK 180
  181 ELTGGSMDKL ILLEKINHWW LSFCQQMIMI RSIFLYMDRT YVLQNSTVHS IWDMGLDLFR 240
  241 IHFAQNSVVQ KRTVDGLLTL IEKERQGSTV DRGLLKSLVR MLCDLQIYTS SFEEKFLDAT 300
  301 NQLYKAESQR KMQELEVPEY LQHVNKRLAE ENERLRHYLD SSTKHPLIYN VEKELLAEHL 360
  361 TSILQKGLDS LLEDNRLSDL TLLYGLLSRV KNGTSELCGN FNGFIKKKGR TIVIDPEKDK 420
  421 SMVQDLLDFK DKMDVIVRTC FEHNEKFTNS LREAFEFFIN QRANKPAELI AKYVDMKLRS 480
  481 GNKGTTDEEL EKTLDKIMVL FRFIHGKDVF EAFYKKDLAK RLLVGKSASV DSEKSMLSKL 540
  541 KQECGGGFTS KLEGMFKDME LSRDINIAFR GHALSNNRDV HNLDLCVSIL TMGYWPTYAP 600
  601 TEVTMPPQFI NPQQIFNKFY LEKHSGRKLQ WQPTLGNCML RAQFDAGPKE LLVSLFQALV 660
  661 LLLFNDKPVL SYEEILAATL IEDGELRRTL QSLACGRARV ITKTPKGREI LDGDQFDFNN 720
  721 EFTNKLFRIK INQIQMKETN EEQKATEERV FQDRQYQIDA AIVRIMKMRK TLSHNLLITE 780
  781 LFNQLTFPVK PADLKKRIES LIDRDYMERD KDNQNQYNYV A

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..110] deduced N/A No confident structure predictions are available.
    2 View Details [111..821] PSI-BLAST 1000.0 No description for 2hyeC was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  9.47178230940453 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  9.15192834197166 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  8.12051073361876 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  6.87003086224111 bayes_pls_golite062009
  • transcription regulator activity
    		•  5.55329976718261 bayes_pls_golite062009
  • transcription factor activity
    		•  4.33152142980289 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.85678231380989 bayes_pls_golite062009
  • ligase activity
    		•  3.66453881539688 bayes_pls_golite062009
  • transcription activator activity
    		•  2.37668609508629 bayes_pls_golite062009
  • binding
    		•  2.3219000606044 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.21939548334548 bayes_pls_golite062009
  • protein binding
    		•  2.20237620151495 bayes_pls_golite062009
  • vasopressin activated calcium mobilizing receptor activity
    		•  2.15618962838168 bayes_pls_golite062009
  • DNA binding
    		•  2.06132216820898 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.70025468248325 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.33374581364046 bayes_pls_golite062009
  • specific transcriptional repressor activity
    		•  0.96257232341735 bayes_pls_golite062009
  • transporter activity
    		•  0.891050405674973 bayes_pls_golite062009
  • transcription factor binding
    		•  0.85714789329232 bayes_pls_golite062009
  • DNA replication origin binding
    		•  0.71823621709622 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.697234220778482 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.648150681919233 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.368917395770011 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.322180400748724 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.300899564141452 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.286130392009263 bayes_pls_golite062009
  • structural molecule activity
    		•  0.272316540117209 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.257777071965243 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.249771970501337 bayes_pls_golite062009
  • catalytic activity
    		•  0.201606344181603 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.175575779922515 bayes_pls_golite062009
  • hydrolase activity
    		•  0.140191206949582 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.107671044044222 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.0912115683429473 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.0856082199488197 bayes_pls_golite062009
  • transferase activity
    		•  0.064832527337659 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle