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View Structure Prediction Details

Protein: Cul-4-PB, Cul-4-PA
Organism: Drosophila melanogaster
Length: 821 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Cul-4-PB, Cul-4-PA.

Description E-value Query
Range
Subject
Range
gi|195153817, gi... - gi|195153817|ref|XP_002017820.1| GL17383 [Drosophila persimilis], gi|194113616|gb|EDW35659.1| GL1738...
gi|54636092, gi|... - gi|54636092|gb|EAL25495.1| GA21273 [Drosophila pseudoobscura pseudoobscura], gi|125808919|ref|XP_001...
gi|54636092|gb|E... - GA21273-PA [Drosophila pseudoobscura], GA21273 [Drosophila pseudoobscura pseudoobscura]
842.0 [0..1] [821..1]

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Predicted Domain #1
Region A:
Residues: [1-110]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAAKKYKPM DTTELHENTE NIAACLKKAE NVAPTAAAAS SVGRSAFAAQ NMNSASTNGE  60
   61 RLPNFSKLGG SHGEIRTAST TSNLLNRMGA IHNSKPGDVK KIVIKNFKDK 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [111-821]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PTLPDNYSKD TYVKLEEAVI AIQLSKPIKY SLEELYQAVV NMCSHKMDAQ LYAKLKELTE  60
   61 QHVKRNIKLK ELTGGSMDKL ILLEKINHWW LSFCQQMIMI RSIFLYMDRT YVLQNSTVHS 120
  121 IWDMGLDLFR IHFAQNSVVQ KRTVDGLLTL IEKERQGSTV DRGLLKSLVR MLCDLQIYTS 180
  181 SFEEKFLDAT NQLYKAESQR KMQELEVPEY LQHVNKRLAE ENERLRHYLD SSTKHPLIYN 240
  241 VEKELLAEHL TSILQKGLDS LLEDNRLSDL TLLYGLLSRV KNGTSELCGN FNGFIKKKGR 300
  301 TIVIDPEKDK SMVQDLLDFK DKMDVIVRTC FEHNEKFTNS LREAFEFFIN QRANKPAELI 360
  361 AKYVDMKLRS GNKGTTDEEL EKTLDKIMVL FRFIHGKDVF EAFYKKDLAK RLLVGKSASV 420
  421 DSEKSMLSKL KQECGGGFTS KLEGMFKDME LSRDINIAFR GHALSNNRDV HNLDLCVSIL 480
  481 TMGYWPTYAP TEVTMPPQFI NPQQIFNKFY LEKHSGRKLQ WQPTLGNCML RAQFDAGPKE 540
  541 LLVSLFQALV LLLFNDKPVL SYEEILAATL IEDGELRRTL QSLACGRARV ITKTPKGREI 600
  601 LDGDQFDFNN EFTNKLFRIK INQIQMKETN EEQKATEERV FQDRQYQIDA AIVRIMKMRK 660
  661 TLSHNLLITE LFNQLTFPVK PADLKKRIES LIDRDYMERD KDNQNQYNYV A

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1000.0
Match: 2hyeC
Description: No description for 2hyeC was found.

Predicted functions:

Term Confidence Notes
ubiquitin-protein ligase activity 9.47178230940453 bayes_pls_golite062009
small conjugating protein ligase activity 9.15192834197166 bayes_pls_golite062009
acid-amino acid ligase activity 8.12051073361876 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 6.87003086224111 bayes_pls_golite062009
transcription regulator activity 5.55329976718261 bayes_pls_golite062009
transcription factor activity 4.33152142980289 bayes_pls_golite062009
transcription repressor activity 3.85678231380989 bayes_pls_golite062009
ligase activity 3.66453881539688 bayes_pls_golite062009
transcription activator activity 2.37668609508629 bayes_pls_golite062009
binding 2.3219000606044 bayes_pls_golite062009
nucleic acid binding 2.21939548334548 bayes_pls_golite062009
protein binding 2.20237620151495 bayes_pls_golite062009
vasopressin activated calcium mobilizing receptor activity 2.15618962838168 bayes_pls_golite062009
DNA binding 2.06132216820898 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.70025468248325 bayes_pls_golite062009
structure-specific DNA binding 1.33374581364046 bayes_pls_golite062009
specific transcriptional repressor activity 0.96257232341735 bayes_pls_golite062009
transporter activity 0.891050405674973 bayes_pls_golite062009
transcription factor binding 0.85714789329232 bayes_pls_golite062009
DNA replication origin binding 0.71823621709622 bayes_pls_golite062009
DNA-dependent ATPase activity 0.697234220778482 bayes_pls_golite062009
transmembrane transporter activity 0.648150681919233 bayes_pls_golite062009
substrate-specific transporter activity 0.368917395770011 bayes_pls_golite062009
transcription corepressor activity 0.322180400748724 bayes_pls_golite062009
DNA helicase activity 0.300899564141452 bayes_pls_golite062009
double-stranded DNA binding 0.286130392009263 bayes_pls_golite062009
structural molecule activity 0.272316540117209 bayes_pls_golite062009
sequence-specific DNA binding 0.257777071965243 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.249771970501337 bayes_pls_golite062009
catalytic activity 0.201606344181603 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.175575779922515 bayes_pls_golite062009
hydrolase activity 0.140191206949582 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.107671044044222 bayes_pls_golite062009
structural constituent of ribosome 0.0912115683429473 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.0856082199488197 bayes_pls_golite062009
transferase activity 0.064832527337659 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle