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Protein Overview: ninaA-PA

General Information:
Name(s) found: ninaA-PA / FBpp0077688 [FlyBase]
Description(s) found:
Found 31 descriptions.
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  • The gene neither inactivation nor afterpotential A is referred to in FlyBase by the symbol Dmel\ninaA (CG3966, FBgn0002936). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:877293..878270. It has the cytological map location 21E2. There is experimental evidence that it has the molecular function</span>: cyclosporin A binding. There is experimental evidence that it is involved in the biological process</span>: phototransduction; rhodopsin biosynthetic process; phototransduction, visible light; apoptosis in response to endoplasmic reticulum stress. 58 alleles are reported. The phenotypes of these alleles are annotated with: photoreceptor cell R2; photoreceptor cell; photoreceptor cell R1; photoreceptor cell R6; photoreceptor cell R5; ommatidium; photoreceptor cell R4; photoreceptor cell R3. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 237 amino acids

    Gene Ontology:
    Cellular Component: membrane fraction [IDA]
    endoplasmic reticulum lumen [IDA]
    integral to plasma membrane [NAS]
    [NOT]nuclear membrane [IDA]
    integral to membrane [IDA]
    cytoplasmic membrane-bounded vesicle [IDA]
    [NOT]rhabdomere [IDA]
    Biological Process: phototransduction, visible light [IMP]
    rhodopsin biosynthetic process [IMP][NAS][TAS]
    apoptosis in response to endoplasmic reticulum stress [IMP]
    protein folding [IEA]
    'de novo' protein folding [NAS][TAS]
    phototransduction [IPI][NAS][TAS]
    transport [TAS]
    Molecular Function: cyclosporin A binding [IMP]
    peptidyl-prolyl cis-trans isomerase activity [ISS][NAS][TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKSLLNRIIL CSAFLAVASG LSFTVTSRIY MDVKHNKKPV GRITFGLFGK LAPKTVANFR  60
   61 HICLRGINGT SYVGSRFHRV VDRFLVQGGD IVNGDGTGSI SIYGDYFPDE DKALAVEHNR 120
  121 PGYLGMANRG PDTNGCQFYV TTVGAKWLDG KHTVFGKVLE GMDTIYAIED VKTDTDDFPV 180
  181 EPVVISNCGE IPTEQFEFYP DDFNILGWIK AAGLPVTSSF CVLLIFHYFF RQLNMYC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..237] PSI-BLAST 66.0 Cyclophilin (eukaryotic)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein deacetylase activity
    		•  4.3775483906311 bayes_pls_golite062009
  • histone deacetylase activity
    		•  4.29026678196473 bayes_pls_golite062009
  • peptidyl-prolyl cis-trans isomerase activity
    		•  3.73853378771688 bayes_pls_golite062009
  • cis-trans isomerase activity
    		•  3.66963215732405 bayes_pls_golite062009
  • deacetylase activity
    		•  3.49940864924766 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
    		•  3.01511519120932 bayes_pls_golite062009
  • RNA binding
    		•  2.94609837984526 bayes_pls_golite062009
  • isomerase activity
    		•  1.96529188741504 bayes_pls_golite062009
  • binding
    		•  1.65866393331484 bayes_pls_golite062009
  • mRNA binding
    		•  1.45537055700871 bayes_pls_golite062009
  • unfolded protein binding
    		•  1.38124355054041 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.939772862764466 bayes_pls_golite062009
  • catalytic activity
    		•  0.748655649755714 bayes_pls_golite062009
  • peptide binding
    		•  0.67282880810423 bayes_pls_golite062009
  • hydrolase activity
    		•  0.493806105600863 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  0.408539130322443 bayes_pls_golite062009
  • drug binding
    		•  0.36339132904137 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  0.322244688184474 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  0.286133802341887 bayes_pls_golite062009
  • histone binding
    		•  0.268719695649015 bayes_pls_golite062009
  • protein binding
    		•  0.230077752280113 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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