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Protein Overview: Alg-2-PD

General Information:
Name(s) found: Alg-2-PD / FBpp0291025 [FlyBase]
Description(s) found:
Found 10 descriptions.
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  • The gene Apoptosis-linked gene-2 is referred to in FlyBase by the symbol Dmel\Alg-2 (CG40410, FBgn0086378). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3RHet:1894569..1899122. Based on sequence similarity, it is predicted to have molecular function</span>: calcium ion binding. There is experimental evidence that it is involved in the biological process</span>: positive regulation of JNK cascade. One allele is reported. The phenotypes of this allele are annotated with: eye; wing hair. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 219 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: positive regulation of JNK cascade [IDA][NAS]
    apoptosis [NAS]
    Molecular Function: calcium ion binding [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAYNHDGMPD QQFLWDVFQR VDKDRSGHIS ADELQVALSN GTWSAFNPET IRLMIGMFDR  60
   61 ENKGTVSFKD FGALWKYVTD WQNCFRSFDR DNSGNIDKTE LKTALTSFGY RLSDHLIDVL 120
  121 LRKFDRFGRG TILFDDFIQC CIVLYVSMTV IAIYEYKVAV GSRDFRCLAY EKIFEIALKP 180
  181 ARKNCMAFRV FSNVFANKRS PLINMSERYS RVLYYQLLR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..219] PSI-BLAST 24.39794 Apoptosis-linked protein alg-2

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • N-terminal myristoylation domain binding
    		•  5.00447869061432 bayes_pls_golite062009
  • calcium ion binding
    		•  3.79609619542776 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  3.49668552859347 bayes_pls_golite062009
  • myosin heavy chain binding
    		•  3.47664712991566 bayes_pls_golite062009
  • motor activity
    		•  3.25814691068414 bayes_pls_golite062009
  • binding
    		•  3.17556402087346 bayes_pls_golite062009
  • metal ion binding
    		•  2.62077305565026 bayes_pls_golite062009
  • cation binding
    		•  2.62077305565026 bayes_pls_golite062009
  • ion binding
    		•  2.61312132078717 bayes_pls_golite062009
  • tubulin binding
    		•  2.51210014078446 bayes_pls_golite062009
  • actin binding
    		•  2.38676888633305 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.29802198409541 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.28098452079347 bayes_pls_golite062009
  • protein binding
    		•  2.21291432166051 bayes_pls_golite062009
  • microtubule binding
    		•  2.17136406283012 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.12961051741613 bayes_pls_golite062009
  • myosin II heavy chain binding
    		•  1.88775123370459 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  1.74951443813569 bayes_pls_golite062009
  • structural constituent of muscle
    		•  1.59541980494825 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.29595371278065 bayes_pls_golite062009
  • transporter activity
    		•  1.15928534291452 bayes_pls_golite062009
  • signal transducer activity
    		•  1.11607939838219 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.11607939838219 bayes_pls_golite062009
  • microfilament motor activity
    		•  1.0725773039399 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.02715871704923 bayes_pls_golite062009
  • DNA binding
    		•  0.98588735736701 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.945691505472547 bayes_pls_golite062009
  • cation channel activity
    		•  0.856991182112951 bayes_pls_golite062009
  • actin-dependent ATPase activity
    		•  0.83859958498483 bayes_pls_golite062009
  • actin filament binding
    		•  0.836375875773328 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.787740261079819 bayes_pls_golite062009
  • kinase activity
    		•  0.782396352346639 bayes_pls_golite062009
  • G-protein beta/gamma-subunit binding
    		•  0.77824189826064 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.654002071540024 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.438908712437433 bayes_pls_golite062009
  • hydrolase activity
    		•  0.378268353045111 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.366129174039334 bayes_pls_golite062009
    		• 0.34446792626966 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  0.341357838238159 bayes_pls_golite062009
  • channel regulator activity
    		•  0.32809521759917 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  0.308919475701377 bayes_pls_golite062009
  • transferase activity
    		•  0.304928629994907 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  0.304496519713588 bayes_pls_golite062009
  • potassium channel activity
    		•  0.260530997378698 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.246383459363256 bayes_pls_golite062009
  • structural molecule activity
    		•  0.234626449126289 bayes_pls_golite062009
  • gated channel activity
    		•  0.175191914660841 bayes_pls_golite062009
  • voltage-gated potassium channel activity
    		•  0.157059988605635 bayes_pls_golite062009
  • myosin binding
    		•  0.125186564742711 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.116648335890738 bayes_pls_golite062009
  • troponin T binding
    		•  0.110771673973181 bayes_pls_golite062009
  • channel activity
    		•  0.0711800677928949 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.0711800677928949 bayes_pls_golite062009
  • ion channel activity
    		•  0.0166394982861724 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.83

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle