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Protein Overview: MSH2_RAT

General Information:
Name(s) found: MSH2_RAT [Swiss-Prot]
Description(s) found:
Found 17 descriptions.
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  • DNA mismatch repair protein Msh2 OS=Rattus norvegicus GN=Msh2 PE=2 SV=1 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 933 amino acids

    Gene Ontology:
    Cellular Component: nucleus [UNKNOWN][IMP]
    MutSalpha complex [UNKNOWN][IEA]
    MutSbeta complex [UNKNOWN][IEA]
    Biological Process: cell cycle arrest [UNKNOWN][IEA]
    somatic recombination of immunoglobulin gene segments [UNKNOWN]
    DNA repair [UNKNOWN]
    response to X-ray [UNKNOWN][IEA]
    male gonad development [UNKNOWN][IEA]
    determination of adult lifespan [UNKNOWN][IEA]
    response to amino acid stimulus [IEP]
    positive regulation of helicase activity [UNKNOWN][IEA]
    postreplication repair [UNKNOWN][ISS]
    double-strand break repair [UNKNOWN][IEA]
    negative regulation of neuron apoptosis [UNKNOWN][IEA]
    oxidative phosphorylation [UNKNOWN][IEA]
    maintenance of DNA repeat elements [UNKNOWN][IEA]
    in utero embryonic development [UNKNOWN][IEA]
    apoptosis [UNKNOWN]
    intra-S DNA damage checkpoint [UNKNOWN][IEA]
    B cell mediated immunity [UNKNOWN][IEA]
    isotype switching [UNKNOWN][IEA]
    germ cell development [UNKNOWN][IEA]
    B cell differentiation [UNKNOWN][IEA]
    spermatogenesis [IEP]
    mismatch repair [UNKNOWN][IEA]
    response to organic cyclic substance [IEP]
    response to DNA damage stimulus [UNKNOWN]
    cell cycle [IEA]
    negative regulation of DNA recombination [UNKNOWN][IEA]
    somatic recombination of immunoglobulin genes during immune response [UNKNOWN]
    response to drug [IEP]
    negative regulation of apoptosis [UNKNOWN]
    response to UV-B [UNKNOWN][IEA]
    somatic hypermutation of immunoglobulin genes [UNKNOWN][IEA]
    Molecular Function: ATPase activity [UNKNOWN][IEA]
    identical protein binding [UNKNOWN]
    dinucleotide repeat insertion binding [UNKNOWN][IEA]
    protein homodimerization activity [UNKNOWN][IEA]
    single guanine insertion binding [UNKNOWN][IEA]
    protein C-terminus binding [UNKNOWN][IEA]
    single thymine insertion binding [UNKNOWN][IEA]
    double-stranded DNA binding [UNKNOWN]
    ADP binding [UNKNOWN][IEA]
    four-way junction DNA binding [UNKNOWN][IEA]
    damaged DNA binding [UNKNOWN][IEA]
    single-stranded DNA binding [UNKNOWN][IEA]
    nucleotide binding [IEA]
    magnesium ion binding [UNKNOWN][IEA]
    DNA binding [UNKNOWN][ISS]
    ATP binding [UNKNOWN][IEA]
    MutLalpha complex binding [UNKNOWN][IEA]
    protein binding [UNKNOWN]
    mismatched DNA binding [UNKNOWN]
    dinucleotide insertion or deletion binding [UNKNOWN]
    centromeric DNA binding [UNKNOWN][IEA]
    guanine/thymine mispair binding [UNKNOWN][IEA]
    oxidized purine DNA binding [UNKNOWN][IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAVQPKETLQ LEGAAEVGFV RFFEGMPEKP STTVGLFDRG DFYTAHGEDA LLAAREVFKT  60
   61 QGVIKYMGPA GAKTLQTVVL SKMNFESFVK DLLLVRHYRV EVYKNKAGNK ASKENDWYLA 120
  121 YKASPGNLSQ FEDILFGNND MATSIGIMGI KLSTVDGQRQ VGVGDVDSTQ RKLGLCEFPD 180
  181 NDQFSNLEAL LIQIGPKECI LPGGETAGDM GKLRQVIQRG GILITERKRI DFSTKDIYQD 240
  241 LNRLLKGRKG EQMNSAVLPE MENQVAVSSL SAVIKFLELL SDDSNFGQFE LATFDFSQYM 300
  301 KLDMAAVRAL NLFQGSVEDT TGSQSLAAFL NKCKTAQGQR LVSQWIKQPL MDKNRIEERL 360
  361 NLVEAFVEDS ELRRALQEDL LRRFPDLNRL AKKFQRQAAN LQDCYRLYQG VKQLPNVIQA 420
  421 LEKYQGRHQA LLLAVFVTPL TDLRSDFSKF QEKIETTLDM DQVENHEFLV KPSFDPNLSE 480
  481 LREVMDGLEK KMQSTLISAA RGLGLDPGKQ IKLDSSAQFG YYFRVTCKEE KVLRNNKNFS 540
  541 TVDIQKNGVK FTNSELSSLN EEYTKNKGEY EEAQDAIVKE IVNISSGYVE PMQTVNDVLA 600
  601 HLDAVVSFAH VSNAAPVPYV RPVILEKGKG RIIVKASRHA CVEVQHDVAF IPNDVHFEKD 660
  661 KQMFHIITGP NMGGKSTYIR QTGVIVLMAQ IGCFVPCESA EVSIVDCILA RVGAGDSQLK 720
  721 GVSTFMAEML ETASILRSAT KDSLIIIDEL GRGTSTYDGF GLAWAISEYI ATNIGAFCMF 780
  781 ATHFHELTAL ASQIPTVNNL HVTALTTEET LTMLYQVKTG VCDQSFGIHV AELANFPRHV 840
  841 IECAKQKALE LEEFQSIGTS QGHDETQPAA KRRCLEREQG EKIILEFLSK VKQVPFTDLS 900
  901 EESVSVKLKQ LKAEVLAKNN SFVNEIISRV KAP

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle