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A cascade of processes induced by the detection of DNA damage within a cell. The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. The slowing of DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progession. Any cell cycle checkpoint that delays or arrests cell cycle progression in response to changes in DNA structure. A signal transduction pathway, induced by DNA damage, that blocks cell cycle progression (in G1, G2 or metaphase) or slows the rate at which S phase proceeds.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: intra-S DNA damage checkpoint
Acc: GO:0031573
Aspect: Biological Process
Desc: The slowing of DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progession.
Proteins in PDR annotated with:
   This term: 27 [Search]
   Term or descendants: 27 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0031573 - intra-S DNA damage checkpoint (interactive image map)
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